Synaptosomes prepared from fresh human cerebral cortex; morphology, respiration and release of transmitter amino acids.

Abstract:

:Synaptosomes prepared from fresh human cerebral cortex were shown to be morphologically similar to those from other species. On incubation, they took up oxygen at a high and linear rate and accumulated potassium against a concentration gradient. In response to depolarization by raised extracellular K+ or addition of veratrine, they showed increased respiration, lowered tissue potassium, and enhanced release of glutamate, aspartate and GABA. The preparation may be of value for studies of neurological disorders.

journal_name

Brain Res

journal_title

Brain research

authors

Dodd P,Hardy JA,Oakley AE,Strong AJ

doi

10.1016/0006-8993(81)90871-4

subject

Has Abstract

pub_date

1981-11-16 00:00:00

pages

419-25

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)90871-4

journal_volume

224

pub_type

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