Abstract：
:Rats were trained on a radial maze and then given electrolytic lesions of the MS followed by a single intraseptal injection of 5 micrograms of NGF. Three days later they were re-tested on the maze. They were also post-operatively tested for hyperemotionality. MS lesions severely impaired performance on the radial maze and produced increased emotionality. MS lesions also produced a general decrease in hippocampal high affinity choline transport and acetylcholinesterase staining, which was not affected by NGF administration. NGF treatment ameliorated the behavioral deficit in the radial maze but had no effect on the hyperemotionality. In order to determine whether the NGF was working to restore previously learned spatial abilities, the type of learning strategy used by the animals was also assessed. NGF treatment did not restore previously learned spatial strategies but facilitated recovery of alternative learning strategies. The reduction in cognitive deficit was also paralleled by reduced ventricular enlargement in the NGF treated rats. The present results suggest that a single injection of NGF can produce a long-lasting improvement on a cognitive task and reduce some of the injury-induced, secondary reactive changes that occur following electrolytic MS lesions.
journal_name
Brain Resjournal_title
Brain researchauthors
Janis LS,Glasier MM,Martin G,Stackman RW,Walsh TJ,Stein DGdoi
10.1016/0006-8993(95)00242-isubject
Has Abstractpub_date
1995-05-08 00:00:00pages
99-109issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)00242-Ijournal_volume
679pub_type
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