Abstract：
:Nuclear retention of radioactivity was studied in neural estrogen target cells 15 min-7 h after i.v. injection of [3H]estradiol. Maximal uptake occurred by 15 min. Cells of the medial preoptic nucleus retained the label longer than did those of the medial amygdaloid nucleus. Cells of the ventromedial nucleus and arcuate nucleus exhibited similar retention profiles which were intermediate between the medial preoptic and medial amygdaloid cells. These data are discussed in relation to observations that the duration of nuclear occupancy by estrogens is proportional to the magnitude of the cellular response.
journal_name
Brain Resjournal_title
Brain researchauthors
Keefer DAdoi
10.1016/0006-8993(81)90761-7subject
Has Abstractpub_date
1981-12-14 00:00:00pages
224-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(81)90761-7journal_volume
229pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.094
更新日期：2007-09-07 00:00:00
abstract：:Intracerebral injection of kainic acid (KA) in rat brain was previously found to cause altered immunohistochemical recognition of connexin-43 (Cx43) epitopes (epitope masking) with different sequence-specific antibodies against this gap junction protein. We demonstrate here that similar alterations occur when nitrocel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00337-p
更新日期：1995-06-12 00:00:00
abstract：:The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91318-1
更新日期：1986-02-26 00:00:00
abstract：:Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03191-7
更新日期：2001-02-09 00:00:00
abstract：:Multidrug efflux transporters of the ATP-Binding cassette (ABC) family, P-glycoprotein (Pgp), multidrug-resistance associated protein 4 (MRP4) and breast cancer resistance protein (BCRP), located on endothelial cells lining brain vasculature play important roles in limiting movement of substances into and enhancing th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.034
更新日期：2010-10-28 00:00:00
abstract：:The dopaminergic regulation of prolactin (PRL) and growth hormone (GH) synthesis were studied in monolayer cultures of rat pituitary tumor (GH3) cells. PRL synthesis could not be inhibited by dopamine at concentrations ranging from 10(-9) to 10(-5) M. Bromocriptine inhibited PRL synthesis only at the very high concent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90808-9
更新日期：1983-06-27 00:00:00
abstract：:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03975-6
更新日期：2003-02-07 00:00:00
abstract：:This study was designed to elucidate the origin of norepinephrine (NE) measured in spinal cord following trauma. In normal cats the NE concentration at the lesion site increased 63% over control 1 h following experimentally produced blunt trauma (400 g-cm). Spinal cords of adrenalectomized cats were also traumatized, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90536-9
更新日期：1976-06-11 00:00:00
abstract：:Parasympathetic innervation to eyelid smooth muscle inhibits sympathetic neurotransmission pre-junctionally without appreciable direct post-junctional effects. However, 5 weeks after sympathectomy, parasympathetic stimulation elicits substantial cholinergically mediated contractions. This study examined ultrastructura...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01439-x
更新日期：1998-03-09 00:00:00
abstract：:There are different kinds of visuomotor learnings. One of the most studied is error-based learning where the information about the sign and magnitude of the error is used to update the motor commands. However, there are other instances where subjects show visuomotor learning even if the use of error sign and magnitude...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.05.022
更新日期：2015-08-27 00:00:00
abstract：:In the striatum and hippocampus, there is a loss of sensitivity to muscarinic agonists with age which has been traced to events early in the signal transduction pathway. Our laboratory has therefore focussed on investigations at this level. The current experiments investigate the effects of age on G-protein/receptor i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90197-h
更新日期：1992-12-11 00:00:00
abstract：:Sleep-related changes-including modification in sensory processing-that influence brain and body functions, occur during both slow wave and paradoxical sleep. Our aim was to investigate how cortical auditory neurons behave during the sleep/waking cycle, and to study cell firing patterns in relation to the processing o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01194-9
更新日期：1999-01-23 00:00:00
abstract：:The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00396-5
更新日期：1998-07-06 00:00:00
abstract：:Rat striata were exposed to 15 mM quinolinic acid (QUIN), or QUIN plus the nitric oxide synthase inhibitors S-methyl-L-thiocitrulline dihydrochloride (L-MIN) or 7-nitroindazole monosodium salt (7-NINA) for 21 days. Co-administration of 100 microM or 1 mM L-MIN with QUIN significantly reduced lesion volume compared to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00962-1
更新日期：1997-11-14 00:00:00
abstract：:Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90676-z
更新日期：1992-02-07 00:00:00
abstract：:Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00617-9
更新日期：1998-08-17 00:00:00
abstract：INTRODUCTION:Apathy is the most common neuropsychiatric syndrome in behavioral variant frontotemporal dementia (bvFTD), and encompasses cognitive, behavioral and affective symptoms. The neural basis of apathy in bvFTD is not completely understood. Previous neuroimaging studies have poorly considered executive impairmen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146799
更新日期：2020-06-15 00:00:00
abstract：:Kappa opioid receptors (KORs) were immunocytochemically localized at four different levels of the spinal cord of normally-cycling female rats in estrus or diestrus. KOR labeling was primarily observed in fine processes and a few neuronal cell bodies in the superficial dorsal horn and the dorsolateral funiculus. Quanti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02515-x
更新日期：2001-06-29 00:00:00
abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02526-5
更新日期：2003-05-30 00:00:00
abstract：:This work examines the age-related changes of the NO pathway in the central nervous system (CNS), analyzing nitric oxide synthase (NOS) isoform expression, the level of nitrotyrosine-modified proteins, and the NOS activity in the cerebral cortex, decorticated brain (basal ganglia, thalamus, hypothalamus, tegtum and te...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03575-8
更新日期：2002-11-29 00:00:00
abstract：:Epileptic discharge patterns in an acute experimental model of epilepsy were analyzed. Epileptic foci were induced by epicortical application of penicillin on the rat motor cortex in vivo. Patterns with regular 1/s discharges, patterns with irregular discharges of about 0.5/s as well as compound patterns comprising di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90221-8
更新日期：1993-07-09 00:00:00
abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03616-8
更新日期：2002-12-06 00:00:00
abstract：:An endogenous opioid peptide, [Met5]-enkephalin, termed opioid growth factor (OGF) is a tonically active, autocrine-produced inhibitory molecule related to developing, neoplastic, renewing and healing tissues. The present investigation was designed to examine the role of OGF on corneal epithelial wound closure in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00610-6
更新日期：1998-08-24 00:00:00
abstract：:The glial cell line-derived neurotrophic factor (GDNF) exerts trophic actions on a number of cell types, including mesencephalic dopaminergic (mDA) neurons. Using rat mesencephalic primary cultures enriched in mDA neurons, we show that protracted GDNF stimulation increases their survival and neurite outgrowth. It modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.071
更新日期：2007-07-23 00:00:00
abstract：:It has been suggested that thiolic groups are essential for cytochrome c oxidase (COX) activity and other respiratory mitochondrial enzymes. Recent experiments showed that the thiolic antioxidant N-acetylcysteine (NAC) can protect against age-related impairment in COX activity in mice hepatic mitochondria. The present...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01819-3
更新日期：1999-09-18 00:00:00
abstract：:Buffy coat of three members from a family with Alzheimer's disease was inoculated into hamster brains. Eighteen months after the inoculation, all experimental animals were sacrificed for the neuropathological study. Hematoxylin-eosin staining showed no gross vacuolar degeneration, or neuronal loss in the cortex. The s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90949-v
更新日期：1991-06-14 00:00:00
abstract：:In this research, we investigated striatal neurogenesis in 3-, 6-, 12-, and 18-month-old rats after cerebral ischemic injury. All rats were subjected to a 20-min middle cerebral artery occlusion (MCAO), given 5'-bromodeoxyuridine (BrdU, 30 mg/kg, i.p.) once daily during days 4-7 and sacrificed 2 weeks after MCAO. Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.043
更新日期：2007-08-29 00:00:00
abstract：:The neuronal mechanisms of sneezing were examined in precollicular-postmammillary decerebrate cats. Mechanical stimulation (frequency 20 Hz, peak-to-peak displacement 0.5 mm) of the nasal membrane evoked a series of sneezes. In the same preparation, electrical stimulation (duration 0.2 ms, frequency 10 Hz, 5-50 microA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90171-7
更新日期：1990-03-19 00:00:00
abstract：:Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3-6 and 9-16. In both age groups, significant correlations were observed between membrane time constant ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00578-7
更新日期：1997-09-05 00:00:00
abstract：:We showed previously, using in vitro microdialysis, that the activation of the soluble guanylate cyclase (sGC)/cyclic GMP pathway was the underlying mechanism of the extracellular Ca(2+)-dependent effects of exogenous NO on dopamine (DA) secretion from PC12 cells. In this study, the co-infusion of the sGC inhibitor 1H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.040
更新日期：2004-10-15 00:00:00
