Kappa opioid receptor density is consistent along the rostrocaudal axis of the female rat spinal cord.

Abstract:

:Kappa opioid receptors (KORs) were immunocytochemically localized at four different levels of the spinal cord of normally-cycling female rats in estrus or diestrus. KOR labeling was primarily observed in fine processes and a few neuronal cell bodies in the superficial dorsal horn and the dorsolateral funiculus. Quantitative light microscopic densitometry of the superficial dorsal horn revealed that there were no significant differences in KOR densities among spinal segments C1--C2, T2, T13--L1, and L6--S1 in either the estrus or diestrus phases. These results suggest that the potential for KOR-mediated antinociceptive responses is consistent along the rostrocaudal axis of the female rat spinal cord.

journal_name

Brain Res

journal_title

Brain research

authors

Harris JA,Drake CT

doi

10.1016/s0006-8993(01)02515-x

subject

Has Abstract

pub_date

2001-06-29 00:00:00

pages

236-9

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(01)02515-X

journal_volume

905

pub_type

杂志文章
  • Ontogenesis of muscarinic receptors in cultured rat hippocampal cells.

    abstract::The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90019-8

    authors: Fernandez-Tomé P,Segal M

    更新日期:1987-09-01 00:00:00

  • Neural responses to bitter compounds in rats.

    abstract::To determine whether the idiosyncratic distribution of transduction mechanisms for bitter tastants in rat taste receptor cells (TRCs) could be inferred from the neural activity they evoke, single neuron responses to ten bitter-tasting compounds were recorded from rat glossopharyngeal (n = 30) and chorda tympani (n = 2...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00131-5

    authors: Dahl M,Erickson RP,Simon SA

    更新日期:1997-05-09 00:00:00

  • Inhibition of intracranial self-stimulation in brain stem-transected cats--a proposed mechanism of aversive effects produced by brain stimulation.

    abstract::Effects of intracranial self-stimulation of central 'punishment areas' were studied on an operant conditioning of vertical eye movements in the midpontine pretrigeminal cats as well as in the encéphale isolé cats. In 36 pretrigeminal cats, the ventromedial hypothalamus (VMH), basal amygdaloid nuclei (AMY), dorsal cent...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91008-8

    authors: Ikegami S,Kawamura H

    更新日期:1981-12-21 00:00:00

  • Alterations in tyrosine hydroxylase activity elicited by raphe nuclei lesions in the rat locus coeruleus: evidence for the involvement of serotonin afferents.

    abstract::The time course of the variations in tyrosine hydroxylase (TH) activity was measured in the rat locus coeruleus (LC) after lesions of the nucleus raphe dorsalis (NRD), nucleus raphe centralis superior (NRCS) and nucleus raphe pontis (NRP). A certain number of lesions were performed in the raphe magnus (RM), the caudal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)91008-3

    authors: McRae-Degueurce A,Berod A,Mermet A,Keller A,Chouvet G,Joh TH,Pujol JF

    更新日期:1982-03-11 00:00:00

  • Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions.

    abstract::Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.12.058

    authors: Roman C,Lin JY,Reilly S

    更新日期:2009-03-09 00:00:00

  • Hypertension induced changes in cerebral capillary permeability to water are mediated by afferent neuronal connections from the carotid sinus to the brain.

    abstract::Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy. The extraction fraction of water (Ew) was measured in both hypertensive and normotensive animals. It was demonstrated that cerebral blood flow did not change during hypertensi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91069-2

    authors: Ling RT,Hartman BK,Clark HB

    更新日期:1984-08-13 00:00:00

  • Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635.

    abstract::Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03243-2

    authors: Parsey RV,Oquendo MA,Simpson NR,Ogden RT,Van Heertum R,Arango V,Mann JJ

    更新日期:2002-11-08 00:00:00

  • Ethical issues related to brain organoid research.

    abstract::This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2020.146653

    authors: Hyun I,Scharf-Deering JC,Lunshof JE

    更新日期:2020-04-01 00:00:00

  • Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools.

    abstract::Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Studies reported in this paper...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90552-9

    authors: Shank RP,Bennett GS,Freytag SO,Campbell GL

    更新日期:1985-03-11 00:00:00

  • Intracellular study of synaptic events related to phase-locking responses of cat cochlear nucleus cells to low frequency tones.

    abstract::In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90286-9

    authors: Britt RH

    更新日期:1976-08-13 00:00:00

  • Rapid changes in extracellular glucose levels and blood flow in the striatum of the freely moving rat.

    abstract::The dynamics of regional cerebral blood flow and brain extracellular glucose were studied in the freely moving rat. These two variables were measured in the striatum during and following both mild tail pinch and restraint stress. Blood flow was monitored using a refinement of the hydrogen clearance technique that allo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90373-u

    authors: Fellows LK,Boutelle MG

    更新日期:1993-02-26 00:00:00

  • Effect of amniotic-fluid ingestion on vaginal-cervical-stimulation-induced Fos expression in female rats during estrus.

    abstract::Placental Opioid-Enhancing Factor (POEF) is a substance found in amniotic fluid (AF) that, when ingested, potentiates opioid-mediated, but not non-opioid-mediated, hypoalgesia. Vaginal-cervical stimulation (VCS) produces a stimulus-bound, partially opioid-mediated hypoalgesia that previous research has shown to be pot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.12.055

    authors: Hoey RF,Hurley SW,Daniels D,Kristal MB

    更新日期:2011-02-28 00:00:00

  • Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats.

    abstract::We investigated the effects of collagen II-induced arthritis on two cerebrospinal fluid (CSF) enzymes converting dynorphin A and substance P (SP), namely dynorphin-converting enzyme (DCE) and substance P endopeptidase (SPE). The products generated by these enzymes are the bioactive fragments Leu-enkephalin-Arg6 and su...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90718-o

    authors: Persson S,Post C,Holmdahl R,Nyberg F

    更新日期:1992-05-29 00:00:00

  • Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.

    abstract::Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03259-0

    authors: Guo ZL,Lai HC,Longhurst JC

    更新日期:2002-01-18 00:00:00

  • Morphine withdrawal syndrome: differential participation of structures located within the amygdaloid complex and striatum of the rat.

    abstract::The participation of amygdaloid and striatal structures in the various signs of morphine withdrawal syndrome (MWS) has been investigated using two complementary approaches: intracerebral application of naloxone in various nuclei of dependent rats and effects of various lesions and transections on systemically induced ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90915-6

    authors: Calvino B,Lagowska J,Ben-Ari Y

    更新日期:1979-11-09 00:00:00

  • Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.

    abstract::The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90452-0

    authors: Hand TH,Koob GF,Stinus L,Le Moal M

    更新日期:1988-12-06 00:00:00

  • Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function.

    abstract::We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.08.068

    authors: Sakata A,Mogi M,Iwanami J,Tsukuda K,Min LJ,Fujita T,Iwai M,Ito M,Horiuchi M

    更新日期:2009-12-01 00:00:00

  • Cardiovascular effects of substance P and capsaicin microinjected into the nucleus tractus solitarii of the rat.

    abstract::This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90938-3

    authors: Lukovic L,de Jong W,de Wied D

    更新日期:1987-10-06 00:00:00

  • Streptozotocin-induced diabetes produces a naltrexone-reversible lowering of self-stimulation threshold.

    abstract::Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of contr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91973-9

    authors: Carr KD

    更新日期:1994-11-21 00:00:00

  • Modulation of synaptic efficacy in field CA1 of the rat hippocampus by forskolin.

    abstract::Activation of cAMP-dependent protein kinase (kinase A) has recently been shown to enhance responses evoked by stimulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors in cultured hippocampal pyramidal neurons. Here we report results of experiments designed to determine if activation of the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90803-h

    authors: Chavez-Noriega LE,Stevens CF

    更新日期:1992-03-06 00:00:00

  • Evidence for pore-like opening of the blood-brain barrier following forebrain ischemia in rats.

    abstract::The nature of the delayed blood-brain barrier (BBB) opening that occurs in rats subjected to forebrain ischemia by the technique of two-vessel (carotid) occlusion plus hypovolemic hypotension (2VO ischemia) was probed by examining the simultaneous, trans-barrier movement of two hydrophilic, normally poorly permeative ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00323-5

    authors: Preston E,Foster DO

    更新日期:1997-06-27 00:00:00

  • Short-term and long-term effects of p-chloroamphetamine on hippocampal serotonin and corticosteroid receptor levels.

    abstract::Hippocampal corticosteroid receptors are regulated by corticosterone as well as by neurotransmitters, such as serotonin (5-HT). Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number. However...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00371-v

    authors: Novotney S,Lowy MT

    更新日期:1995-06-26 00:00:00

  • Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease.

    abstract::Elevated levels of oxidative stress or decreased antioxidant defense mechanisms may underlie the regionally increased oxidative damage to brain observed in many neurodegenerative disorders. Phase I detoxification pathways for reactive aldehydes generated from lipid peroxidation include aldehyde dehydrogenases, alcohol...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02897-9

    authors: Picklo MJ Sr,Olson SJ,Hayes JD,Markesbery WR,Montine TJ

    更新日期:2001-10-19 00:00:00

  • Effects of transcranial magnetic stimulation on muscle activation patterns and joint kinematics within a two-joint motor synergy.

    abstract::We studied the effects of transcranial magnetic stimulation (TMS) on muscle activation patterns and joint kinematics during oscillatory movements of a joint within a two-joint (elbow-wrist) synergy. Healthy young adults (N=8) performed cyclic movements in one of the joints while the other joint was or was not involved...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03958-6

    authors: Latash ML,Danion F,Bonnard M

    更新日期:2003-01-31 00:00:00

  • Cardiovascular responses to microinjection of L-glutamate into the NTS in AV3V-lesioned rats.

    abstract::The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.08.006

    authors: Vieira AA,Colombari E,De Luca LA Jr,de Almeida Colombari DS,Menani JV

    更新日期:2004-10-29 00:00:00

  • NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons.

    abstract::Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02990-1

    authors: Schmachtenberg O,Diaz J,Bacigalupo J

    更新日期:2003-08-01 00:00:00

  • Long-term potentiation in the hippocampal slice: possible involvement of pyruvate dehydrogenase.

    abstract::Tetanic stimulation of fibers in the hippocampal slice preparation produces long-term potentiation (LTP) and also decreases the in vitro incorporation of phosphate into the alpha subunit of pyruvate dehydrogenase (alpha PDH). This paper describes 6 experiments that were undertaken to replicate this observation. Hippoc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91292-7

    authors: Hoch DB,Dingledine RJ,Wilson JE

    更新日期:1984-06-04 00:00:00

  • Modulation of hypoxic depressions of ventilatory activity in the newborn piglet by mesencephalic mechanisms.

    abstract::In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01310-9

    authors: St-John WM,St Jacques R,Li A,Darnall RA

    更新日期:1999-02-20 00:00:00

  • Radial glia give rise to perinodal processes.

    abstract::Nodes of Ranvier in the central nervous system in mammals are characterized by the presence of perinodal astrocytic processes. This study examines the association between processes of radial glia and the axolemma at nodes of Ranvier in the spinal cord of the mature axolotl, an animal in which radial glia represent a l...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90595-m

    authors: Sims TJ,Gilmore SA,Waxman SG

    更新日期:1991-05-17 00:00:00

  • Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.

    abstract::Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction. We used 4-9month-old mice of the APP/PS1 mouse model of Alzheimer's disease to study the presence of epileptiform-like discharges and to e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.09.026

    authors: Reyes-Marin KE,Nuñez A

    更新日期:2017-12-15 00:00:00