Dopaminergic regulation of prolactin and growth hormone synthesis in rat pituitary tumor cells.

Abstract:

:The dopaminergic regulation of prolactin (PRL) and growth hormone (GH) synthesis were studied in monolayer cultures of rat pituitary tumor (GH3) cells. PRL synthesis could not be inhibited by dopamine at concentrations ranging from 10(-9) to 10(-5) M. Bromocriptine inhibited PRL synthesis only at the very high concentration of 10(-5) M, and this effect was not reversible by metoclopramide. GH synthesis was inhibited by 10(-6) and 10(-5) M dopamine but not by bromocriptine, and the dopamine effect was blocked by metoclopramide. These results suggest the existence of a defective dopaminergic regulation of PRL and GH synthesis in GH3 cells.

journal_name

Brain Res

journal_title

Brain research

authors

Cheung CY,Melmed S,Braunstein GD

doi

10.1016/0006-8993(83)90808-9

subject

Has Abstract

pub_date

1983-06-27 00:00:00

pages

165-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90808-9

journal_volume

270

pub_type

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