Abstract：
:Rat striata were exposed to 15 mM quinolinic acid (QUIN), or QUIN plus the nitric oxide synthase inhibitors S-methyl-L-thiocitrulline dihydrochloride (L-MIN) or 7-nitroindazole monosodium salt (7-NINA) for 21 days. Co-administration of 100 microM or 1 mM L-MIN with QUIN significantly reduced lesion volume compared to QUIN alone. Co-administration of 1 microM or 10 microM L-MIN with QUIN had no significant effect. There was no significant effect of 7-NINA co-administered with QUIN compared to QUIN alone. L-MIN reduction of lesion volume supports the contention that neuronal nitric oxide synthase is a mediator of excitotoxic injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Bazzett T,Geiger A,Coppola B,Albin Rdoi
10.1016/s0006-8993(97)00962-1subject
Has Abstractpub_date
1997-11-14 00:00:00pages
229-32issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00962-1journal_volume
775pub_type
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