Abstract：
:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid composition, NH2-terminal amino acid residues and the presence of 14C-radioactivity of the residue glycinamide-9. The major peptide fragments of AVT were: (formula; see text) Time course experiments showed the precursor-product interrelationships between these peptides. The results demonstrate that the conversion of AVT by synaptic membranes involves primarily the action of aminopeptidase activity. Comparison between membrane fractions from rat and chicken brain showed that AVT is converted by a similar proteolytic mechanism in chicken brain, but that differences in activity of the aminopeptidase exist. The results are discussed in view of the concept that AVT serves as precursor for neuropeptides with differential activities in non-mammalian vertebrates.
journal_name
Brain Resjournal_title
Brain researchauthors
Wang XC,Burbach JP,Verhoef JC,De Wied Ddoi
10.1016/0006-8993(83)90419-5subject
Has Abstractpub_date
1983-09-19 00:00:00pages
83-90issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(83)90419-5journal_volume
275pub_type
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