Abstract：
:Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of neurons originating outside of the caudate. However, most CCK receptors appear to be located on neuronal cell bodies intrinsic to the caudate nucleus, since local injections of kainic acid reduced caudate CCK receptors by approximately 75%. These findings are similar to recent data from our laboratory on the concentration of CCK receptors in the basal ganglia of patients with Huntington's disease, and suggest that CCK may be involved in the regulation of extrapyramidal motor function.
journal_name
Brain Resjournal_title
Brain researchauthors
Hays SE,Meyer DK,Paul SMdoi
10.1016/0006-8993(81)90284-5subject
Has Abstractpub_date
1981-08-24 00:00:00pages
208-13issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(81)90284-5journal_volume
219pub_type
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