Abstract:
:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing each form of intake following ventricular microinjection. Both mu and kappa opioid antagonists microinjected into either the hypothalamic paraventricular nucleus or the nucleus accumbens reduce intake under deprivation and glucoprivic conditions. Palatable intake is reduced by both antagonists in the paraventricular nucleus, but only mu antagonists are active in the accumbens. Food intake is stimulated by mu and delta, but not kappa, opioid agonists microinjected into the ventral tegmental area. The present study examined whether food intake under either deprivation, glucoprivic or palatable conditions was altered by bilateral administration of general (naltrexone), mu, kappa, delta1 or delta2 (naltrindole isothiocyanate) opioid antagonists into the ventral tegmental area. Deprivation (24 h)-induced feeding was significantly reduced by high (50 microg), but not lower (10-20 microg) doses of naltrexone (21%), and by delta2 (4 microg, 19%) antagonism in the ventral tegmental area. 2-Deoxy-D-glucose (500 mg/kg, i.p.)-induced hyperphagia was significantly reduced by high (50 microg), but not lower (20 microg) doses of naltrexone (64%), and by delta2 (4 microg, 27%) antagonism in the ventral tegmental area. Sucrose (10%) intake was significantly reduced by naltrexone (20-50 microg, 25-39%) and delta2 (4 microg, 25%) antagonism in the ventral tegmental area. Neither mu, kappa nor delta1 antagonists were effective in reducing any form of intake following microinjection into the ventral tegmental area. These data indicate that the ventral tegmental area plays a relatively minor role in the elicitation of these forms of food intake, and that delta2, rather than mu, kappa or delta1 opioid receptors appear responsible for mediation of these forms of intake by this nucleus.
journal_name
Brain Resjournal_title
Brain researchauthors
Ragnauth A,Ruegg H,Bodnar RJdoi
10.1016/s0006-8993(97)00539-8subject
Has Abstractpub_date
1997-08-29 00:00:00pages
8-16issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00539-8journal_volume
767pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Two selectively bred lines of mice, one responding with high (HA) and the other with low analgesia (LA) to 3 min swims at 20 degrees C were compared with respect to naloxone ability to reverse such swim induced pain threshold elevation. Also, the analgesic effect of morphine was tested in both lines of mice. Naloxone ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91380-6
更新日期:1986-11-05 00:00:00
abstract::Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.087
更新日期:2008-11-25 00:00:00
abstract::The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) and glaucoma. Initial in vitro studies on brain membranes showed that EGCG was appro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.067
更新日期:2006-12-08 00:00:00
abstract::We have previously reported that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these angiotensin II-sensitive neurons in the AHA are enhanced in spontaneously hypertensive rats (SHR). In addition, neural activations induced by bot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.11.029
更新日期:2005-02-08 00:00:00
abstract::Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.09.041
更新日期:2011-11-24 00:00:00
abstract::In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied gamma-aminobutyric acid (GABA) and glutamate were monitored before, dur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90634-2
更新日期:1987-01-06 00:00:00
abstract::The L-isomer of beta-N-methylamino-L-alanine (BMAA), present in free form in seed of Cycas circinalis, elicits in spinal cord cultures a pattern of acute postsynaptic neuronal vacuolation comparable to that induced by beta-N-oxalylamino-L-alanine (BOAA), an excitotoxic amino acid of greater potency isolated from seed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90342-8
更新日期:1987-05-05 00:00:00
abstract::The two human brain beta-galactosidases were solubilized and fractionated by Sephadex G-200 gel filtration, free from each other. Substrate specificities of the two enzymes were examined for galactosylceramide, lactosyl-[N-stearoyl]ceramide, lactosyl-[N-lignoceroyl]ceramide, galactosyl-N-acetylgalactosaminyl-[N-stearo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90298-0
更新日期:1977-02-18 00:00:00
abstract::Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.042
更新日期:2009-12-11 00:00:00
abstract::The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90333-6
更新日期:1985-01-28 00:00:00
abstract::The objective of this study was to determine if a prefrontal somatosensory mismatch response (sMMR) could be recorded in response to deviations in duration of somatosensory stimuli. Intracranial somatosensory event-related potentials were recorded from temporal, parietal, and frontal lobe sites in 12 pediatric patient...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.072
更新日期:2010-01-15 00:00:00
abstract::We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90066-9
更新日期:1982-04-01 00:00:00
abstract::Congenitally anophthalmic mice (ZRDCT-AN) have circadian rhythms which 'free-run' and are not light modulated. Their rhythms differ from those of controls in: duration of circadian period, length of active phase, and pattern/intensity of activity. Three different populations have been described based upon wheel-runnin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03272-9
更新日期:2002-10-25 00:00:00
abstract::During a simple reaction time task using auditory or visual stimuli, a total of 96 single units were recorded from the dorsolateral prefrontal cortex of macaque monkeys. These monkeys were trained to depress a lever for a fixed period which produced a tone burst or a small spot of light. After a variable period, the s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91025-3
更新日期:1982-09-09 00:00:00
abstract::Prostaglandins are now thought to play an important role in nociceptive information transmission in the spinal cord. Prostaglandins are known to be produced by cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid. Two forms of COX have been identified: COX-1, which is constitutively expressed in mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00817-7
更新日期:1996-11-11 00:00:00
abstract::We have examined the question of whether alpha-tubulin is detyrosylated during axonal transport in retinal ganglion cell axons and axons of spinal motor neurons. The degree of tyrosylation of alpha-tubulin was estimated from immunocytochemistry and immunoblotting with two anti-alpha-tubulin monoclonals, one of which (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90697-9
更新日期:1986-08-27 00:00:00
abstract::Catecholamine-containing fibers have been examined in the cerebella of normal and hypocerebellar mutant mice using Falck-Hillarp and glyoxylic acid histofluorescence techniques. The amounts of norepinephrine and dopamine were also determined chemically in the same mutants. Green fluorescent fibers in cerebella of norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90349-2
更新日期:1975-08-08 00:00:00
abstract::We consider a random synaptic pruning in an initially highly interconnected network. It is proved that a random network can maintain a self-sustained activity level for some parameters. For such a set of parameters a pruning is constructed so that in the resulting network each neuron/node has almost equal numbers of i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.07.050
更新日期:2012-01-24 00:00:00
abstract::Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.080
更新日期:2008-04-14 00:00:00
abstract::After glucocorticoid stimulation, glucocorticoid receptors (GRs) are translocated to the nucleus to modulate transcription of glucocorticoid target genes. The subcellular distribution and trafficking of GR in cultured cells has been studied quite intensively using several techniques. However, the intracellular localiz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.052
更新日期:2010-05-17 00:00:00
abstract::The coupling of muscarinic-cholinergic receptors (mAChR) to adenylate cyclase and phospholipase C (PLC) second messenger systems has been demonstrated in many animal species. However, little is known about this association in the developing human central nervous system. Because of the proposed role of acetylcholine in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90365-4
更新日期:1994-08-08 00:00:00
abstract::Effects of intracellular accumulation of 3',5'-cyclic adenosine monophosphate (cAMP) were studied using 3',5'-cyclic 8-bromoadenosine monophosphate (8-Br-cAMP) and forskolin on single motoneurons acutely dissociated from adult bullfrog spinal cord. 8-Br-cAMP (10(-3) M) and forskolin (1.5 x 10(-6) M) activated inward c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90787-a
更新日期:1992-02-28 00:00:00
abstract::Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90900-8
更新日期:1994-04-11 00:00:00
abstract::The brain 5-HT1A receptor system in male wild house mice selected for high and low offensive aggression was investigated by autoradiographic analysis of in situ hybridization and radioligand binding. In high-aggressive mice, characterized by a short attack latency, the rise in plasma corticosterone concentration durin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00723-8
更新日期:1996-10-14 00:00:00
abstract::To account for deficits in interval timing observed in Parkinson's Disease (PD) patients, we develop a model based on the accumulating firing rate of a neural population with recurrent excitation. This model naturally produces the curvilinear accumulation of neural activity introduced to timing psychophysics by Miall ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.070
更新日期:2006-01-27 00:00:00
abstract::Unilateral nigrostriatal lesions were performed in rats by punctate injection of 6-hydroxydopamine. Lesioned animals exhibited anorexia and weight loss for 7-11 days after surgery. These animals then displayed normal rate of weight gain. However, there was a chronic depression of body weight in the lesioned animals re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90195-0
更新日期:1977-09-02 00:00:00
abstract::The blood-nerve barrier consists of continuous layers of cells linked by tight junctions and includes the endothelial cells which line the endoneurial capillaries and the perineurial cells which surround fascicles of nerve fibers. A facilitated transport carrier protein allows D-glucose to penetrate the barrier. To de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91115-w
更新日期:1990-01-29 00:00:00
abstract::Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.008
更新日期:2015-04-24 00:00:00
abstract::uinea pig antiserum specific to the purified bovine choline acetyltransferase was used to demonstrate the localization of this enzyme in rabbit forebrain by the peroxidase-antiperoxidase immunohistochemical method. Choline acetyltransferase was localized in olfactory bulb, olfactory tract, olfactory tubercle, piriform...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90196-2
更新日期:1982-03-04 00:00:00
abstract::It has been reported that L-glutamate (L-glu) microinjection into the hypothalamic paraventricular nucleus (PVN) evokes pressor and tachycardiac responses in unanesthetized rats. In the present study the hypothesis was tested that a local nitric oxide (NO)-guanylate cyclase interaction mediates cardiovascular effects ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.023
更新日期:2010-07-16 00:00:00