Abstract：
:The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies of neurons were the primary sites of these alterations. Neuronal mitochondria were distended, and the lamellae of the mitochondrial cristae were separated. In some cases the lamellae had completely dispersed, leaving only matrix remnants. Mitochondria of adjacent astrocytes appeared normal. Thus, a characteristic population of brain mitochondria is selectively vulnerable to a combination of hyperammonemia and octanoic acidemia and may be related to the biochemical mechanisms underlying encephalopathies of hepatic origin.
journal_name
Brain Resjournal_title
Brain researchauthors
Drewes LR,Leino RLdoi
10.1016/0006-8993(85)90916-3subject
Has Abstractpub_date
1985-08-12 00:00:00pages
211-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90916-3journal_volume
340pub_type
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