Role of p75NTR in NMDAR-mediated excitotoxic brain injury in neonatal mice.

Abstract:

BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to its trophic function, also induce apoptosis. HYPOTHESIS:We hypothesised that excitotoxicity increases p75(NTR) expression and p75(NTR) knockout (KO) mice have a significantly smaller lesion size upon excitotoxicity as compared to wild-type (WT) mice. METHODS:We used an established animal model of neonatal excitotoxic brain injury mimicking several key aspects of human preterm brain damage. We subjected five-day-old WT and KO mice to excitotoxic injury by means of a single intracranial ibotenate injection (N-methyl-D-aspartate receptor agonist, NMDAR) into one brain hemisphere. Lesion size, number of activated caspase-3- and apoptosis-inducing factor (AIF)-positive cells were determined as outcome parameters. Gender analyses were taken into account retrospectively. RESULTS:NMDAR-mediated excitotoxicity induced an upregulation of p75(NTR) expression in the peri-lesion area. Lesion size was significantly increased in female KO as compared to male KO animals. Knockout of p75(NTR) reduced the number of activated caspase-3 but not AIF-positive cells after NMDAR-mediated excitotoxic injury independently of gender. CONCLUSION:Since NMDAR-mediated excitotoxic brain injury induced p75(NTR) expression and caspase-3-activated apoptosis in p75(NTR) KO animals was decreased, we conclude that activation of p75(NTR) contributes to NMDAR-mediated apoptosis in the neonatal brain. An increase in lesion size in female animals after excitotoxic brain injury suggests that in females p75(NTR) seems to play a dual role.

journal_name

Brain Res

journal_title

Brain research

authors

Griesmaier E,Schlager G,Wegleiter K,Hermann M,Urbanek M,Simbruner G,Keller M

doi

10.1016/j.brainres.2010.07.095

subject

Has Abstract

pub_date

2010-10-08 00:00:00

pages

31-40

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(10)01697-5

journal_volume

1355

pub_type

杂志文章
  • Development of cytochrome oxidase staining in the retina and lateral geniculate nucleus: a possible correlate of ON- and OFF-center channel maturation.

    abstract::A histochemical stain for cytochrome oxidase (CO) activity was used to examine the maturation of a neurochemical correlate of ON and OFF channels in the retina and dorsal lateral geniculate nucleus (LGN) of the tree shrew. In the adult tree shrew, the CO staining pattern can be used as a histochemical marker of segreg...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90217-3

    authors: Lachica EA,Condo GJ,Casagrande VA

    更新日期:1987-08-01 00:00:00

  • Cholinotoxic effects of beta-amyloid (1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis.

    abstract::Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral f...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00823-9

    authors: Harkany T,Lengyel Z,Soós K,Penke B,Luiten PG,Gulya K

    更新日期:1995-10-09 00:00:00

  • Norepinephrine levels in traumatized spinal cord of catecholamine-depleted cats.

    abstract::This study was designed to elucidate the origin of norepinephrine (NE) measured in spinal cord following trauma. In normal cats the NE concentration at the lesion site increased 63% over control 1 h following experimentally produced blunt trauma (400 g-cm). Spinal cords of adrenalectomized cats were also traumatized, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90536-9

    authors: Schoultz TW,De Luca DC,Reding DL

    更新日期:1976-06-11 00:00:00

  • Changes in morphology of dendritic spines on honeybee calycal interneurons associated with cumulative nursing and foraging experiences.

    abstract::Using the rapid Golgi method, the morphology of dendritic spines was quantified in the calyxes of groups of newly emerged, nurse, and forager honeybees. These groups were studied because they represented distinct stages of behavioral development and cumulative experience which, according to recent vertebrate findings,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)91007-0

    authors: Coss RG,Brandon JG,Globus A

    更新日期:1980-06-16 00:00:00

  • A fMRI study of brain activations during non-noxious and noxious electrical stimulation of the sciatic nerve of rats.

    abstract::An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02094-7

    authors: Chang C,Shyu BC

    更新日期:2001-04-06 00:00:00

  • Cross-species and intraspecies reactivities of monoclonal antibodies against choline acetyltransferase.

    abstract::We have previously reported the first successful production of monoclonal antibodies against the cholinergic neuronal marker, choline acetyltransferase (ChAT). We now report some inter-and intraspecies cross-reactivity studies of the monoclonal antibody AB1. This antibody reacted most strongly with bovine ChAT and wea...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90889-7

    authors: Levey AI,Wainer BH

    更新日期:1982-02-25 00:00:00

  • Developmental expression of multidrug resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid regulation.

    abstract::The multidrug resistance gene (Abcb1) protein product, phosphoglycoprotein (P-gp) is expressed on the luminal surface of capillary endothelial cells of the adult blood-brain barrier (bbb). P-gp is critical for neuroprotection as it actively pumps substrates back into the capillary lumen. The fetal brain represents a p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.08.016

    authors: Petropoulos S,Gibb W,Matthews SG

    更新日期:2010-10-21 00:00:00

  • Developmental immunohistochemistry of bifunctional protein in human brain.

    abstract::Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and P...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91878-3

    authors: Imamura A,Kamei A,Suzuki Y,Orii T,Takashima S

    更新日期:1994-03-21 00:00:00

  • Endogenous endothelin-1 initiates astrocytic growth after spinal cord injury.

    abstract::We developed a rat spinal cord injury model and investigated whether endogenous endothelin (ET)-1 plays a role in astrocytic growth after injury. Immunohistochemical study showed that the number of immature astrocytes (ACs) exhibiting strong reactivity to the monoclonal antibody, RC1, markedly increased 24 h after the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00524-0

    authors: Uesugi M,Kasuya Y,Hama H,Yamamoto M,Hayashi K,Masaki T,Goto K

    更新日期:1996-07-29 00:00:00

  • The collagenase model of intracerebral hemorrhage in awake, freely moving animals: The effects of isoflurane.

    abstract::Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146593

    authors: Wilkinson CM,Kalisvaart ACJ,Kung TFC,Maisey DR,Klahr AC,Dickson CT,Colbourne F

    更新日期:2020-02-01 00:00:00

  • Combined l-citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia.

    abstract::We previously reported that oral l-citrulline (l-Cit) administration antagonizes neuronal cell death in hippocampus following transient brain ischemia and that oral glutathione (GSH) administration prevents neuronal death through antioxidant activity. Here, we tested potential synergy of combined l-Cit and GSH adminis...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.03.014

    authors: Matsuo K,Yabuki Y,Fukunaga K

    更新日期:2017-05-15 00:00:00

  • Right-sided population bias and lateralization of activity in normal rats.

    abstract::Of 602 rats tested for amphetamine-induced or nocturnal rotation (circling behavior), 54.8% (P less than 0.025) had right side biases. Of 292 rats tested in two-lever operant situations, 57.5% (P less than 0.02) preferred the right lever. Right-biased rats were significantly more active and had stronger side preferenc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90737-x

    authors: Glick SD,Ross DA

    更新日期:1981-01-26 00:00:00

  • Nogo-receptor 1 antagonization in combination with neurotrophin-4/5 is not superior to single factor treatment in promoting survival and morphological complexity of cultured dopaminergic neurons.

    abstract::Cell transplantation using ventral mesencephalic tissue is an experimental approach to treat Parkinson's disease. This approach is limited by poor survival of the transplants and the high number of dopaminergic neurons needed for grafting. Increasing the yield of dopaminergic neurons in donor tissue is of great import...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.05.015

    authors: Seiler S,Di Santo S,Sahli S,Andereggen L,Widmer HR

    更新日期:2017-08-01 00:00:00

  • Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5.

    abstract::Protease-activated receptors (PARs), G-protein-coupled receptors, are widely expressed in various tissues, where they participate in physiological and pathological processes, such as hemostasis, proliferation, tissue repair, and inflammation. Recently, we found that PARs were upregulated in the rat retina following op...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.04.040

    authors: Luo W,Wang Y,Reiser G

    更新日期:2005-06-21 00:00:00

  • A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats.

    abstract::The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2003.09.084

    authors: Iihoshi S,Honmou O,Houkin K,Hashi K,Kocsis JD

    更新日期:2004-05-08 00:00:00

  • Vanadate ions: central nervous system action on glucoregulation.

    abstract::Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90615-9

    authors: Amir S,Meyerovitch J,Shechter Y

    更新日期:1987-09-01 00:00:00

  • Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER).

    abstract::Noda epileptic rat (NER), originally found in a colony of Crj; Wistar rats, shows spontaneous tonic-clonic convulsion characterized by the appearance of high voltage polyspikes in cortical and hippocampal EEG once every 2-3 days after 2-4 months of age. Electrophysiological studies using hippocampal slice preparations...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03195-5

    authors: Hanaya R,Sasa M,Kiura Y,Ishihara K,Serikawa T,Kurisu K

    更新日期:2002-09-20 00:00:00

  • Norepinephrine decreases synaptic inhibition in the rat hippocampus.

    abstract::The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antag...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91440-0

    authors: Madison DV,Nicoll RA

    更新日期:1988-02-23 00:00:00

  • Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis.

    abstract::Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90315-9

    authors: Rock JP,Oldfield EH,Schulte HM,Gold PW,Kornblith PL,Loriaux L,Chrousos GP

    更新日期:1984-12-10 00:00:00

  • Effect of lactic acid on L-glutamate uptake in cultured astrocytes: mechanistic considerations.

    abstract::Elevated levels of lactic acid can be deleterious to CNS tissue. Lactic acid is known to cause astroglial swelling and since glial swelling has been shown to inhibit L-glutamate (L-Glu) uptake, we examined whether one of the actions of lactic acid is to inhibit L-Glu uptake. Astrocyte cultures treated with lactic acid...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01331-5

    authors: Bender AS,Young LP,Norenberg MD

    更新日期:1997-03-07 00:00:00

  • Hypocretinergic facilitation of synaptic activity of neurons in the nucleus pontis oralis of the cat.

    abstract::The present study was undertaken to explore the neuronal mechanisms of hypocretin actions on neurons in the nucleus pontis oralis (NPO), a nucleus which plays a key role in the generation of active (REM) sleep. Specifically, we sought to determine whether excitatory postsynaptic potentials (EPSPs) evoked by stimulatio...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02566-6

    authors: Xi MC,Fung SJ,Yamuy J,Morales FR,Chase MH

    更新日期:2003-06-27 00:00:00

  • A distinct type of displaced ganglion cell in a mammalian retina.

    abstract::The morphology, dendritic stratification and laminal position of the soma of retinal ganglion cells were analyzed in Golgi preparations and in other rabbit retinas containing cells backfilled from the superior colliculus. Only one type, among 40 Golgi-impregnated types identified, always had its cell body displaced to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91838-8

    authors: Famiglietti EV

    更新日期:1990-12-03 00:00:00

  • Three-dimensional localization of dipoles for potentials evoked by posterior tibial nerve stimulation in the monkey.

    abstract::Somatosensory evoked potentials (SEPs) elicited by right posterior tibial nerve stimulation were simultaneously recorded from 21-27 epidural electrodes in three monkeys. N23-P40 was recorded anterior to the left central sulcus, and P23-N40 was recorded on the parietal midline and the middle portion of the right hemisp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)81685-x

    authors: Hayashi N,Nishijo H,Endo S,Ono T

    更新日期:1997-11-07 00:00:00

  • Afferents and efferents of the rat cuneiformis nucleus: an anatomical study with reference to pain transmission.

    abstract::Small iontophoretic application of wheat-germ-agglutinin conjugated to horseradish peroxidase, was used to simultaneously observe, in the rat, the afferent and the efferent connections of the cuneiformis nucleus (Cnf), in the same animal. The results demonstrate that the main Cnf afferent connections originate from: (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90449-6

    authors: Bernard JF,Peschanski M,Besson JM

    更新日期:1989-06-19 00:00:00

  • Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease.

    abstract::Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02417-8

    authors: Newman SJ,Bond B,Crook B,Darker J,Edge C,Maycox PR

    更新日期:2000-02-28 00:00:00

  • Immunohistochemical study of flotillin-1 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis.

    abstract::We analyzed flotillin-1 expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that flotillin-1 expression increased significantly in the spinal cords from rats at the peak stage of EAE compared with the levels in control animals (p<0.05) and dec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.07.054

    authors: Kim H,Ahn M,Moon C,Matsumoto Y,Sung Koh C,Shin T

    更新日期:2006-10-09 00:00:00

  • Two successive neurocognitive processes captured by near-infrared spectroscopy: prefrontal activation during a computerized plus-shaped maze task.

    abstract::The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.12.047

    authors: Miyata H,Watanabe S,Minagawa-Kawai Y

    更新日期:2011-02-16 00:00:00

  • The effects of pattern shape, subliminal stimulation, and voluntary control on multistable visual perception.

    abstract::Spontaneous figure reversal of ambiguous patterns was analyzed in humans. A) With Necker-"cube"-like, or "drum"-like figures, having square or round shaped "front" and "rear" surfaces, and either large or small "depth", the perceptual intervals corresponding to both interpretations of "drum" were longer than those of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.04.064

    authors: Taddei-Ferretti C,Radilova J,Musio C,Santillo S,Cibelli E,Cotugno A,Radil T

    更新日期:2008-08-15 00:00:00

  • Dopamine effects on thermosensitive neurons in hypothalamic tissue slices.

    abstract::To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90364-0

    authors: Scott IM,Boulant JA

    更新日期:1984-07-23 00:00:00

  • Protein kinase C gamma-like immunoreactivity of trigeminothalamic neurons in the medullary dorsal horn of the rat.

    abstract::We examined protein kinase C gamma-like immunoreactivity (PKCgamma-LI) of trigeminothalamic neurons in the rat medullary dorsal horn (MDH) after injecting a retrograde tracer, Fluoro-Gold (FG), into the thalamus. Over 90% of FG-labeled neurons in the marginal layer (lamina I) and a few FG-labeled neurons in the superf...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02777-9

    authors: Li YQ,Li JL,Li H,Kaneko T,Mizuno N

    更新日期:2001-09-21 00:00:00