Prolactin-releasing peptide-immunoreactivity in A1 and A2 noradrenergic neurons of the rat medulla.

Abstract:

:Distribution of prolactin-releasing peptide-like immunoreactivity (PrRP-LI) was investigated in the rat medulla with the use of a rabbit polyclonal antiserum against the human PrRP-31 peptide. PrRP-positive neurons were noted mainly in two areas of the caudal medulla: ventrolateral reticular formation and commissural nucleus of the nucleus of the solitary tract (NTS), corresponding to the A1 and A2 areas. PrRP-LI neurons were absent in the medulla rostral to the area postrema. Double-labeling the sections with PrRP antisera and tyrosine hydroxylase (TH) monoclonal antibodies revealed extensive colocalization of PrRP- and TH-like immunoreactivity (TH-LI) in neurons of the A1 and A2 areas. Our results show that PrRP-LI is expressed in a population of A1 and A2 noradrenergic neurons of the rat caudal medulla.

journal_name

Brain Res

journal_title

Brain research

authors

Chen C,Dun SL,Dun NJ,Chang JK

doi

10.1016/s0006-8993(99)01153-1

subject

Has Abstract

pub_date

1999-03-20 00:00:00

pages

276-9

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01153-1

journal_volume

822

pub_type

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