Abstract:
:Eye and head movements during tracking of a smoothly moving visual target were recorded in trained monkeys. The head movement clearly followed the target, although with considerable variability from cycle to cycle. The eye stayed relatively near the primary position and moved in an apparently irregular fashion; however, the sum of eye and head, or gaze, remained accurately on target despite the irregularity of the individual eye and head movements. When compared with tracking with head fixed, head free tracking was not measurably different in accuracy. Further experiments were performed which demonstrated a role for the vestibular system in coordinating eye and head during smooth pursuit. The results of these experiments can be best explained by postulating an internal smooth pursuit command driving both eye and head movements. In the case of the eye movement, this smooth pursuit command is combined with vestibular feedback from head movement before being forwarded to eye movement centers.
journal_name
Brain Resjournal_title
Brain researchauthors
Lanman J,Bizzi E,Allum Jdoi
10.1016/0006-8993(78)91127-7subject
Has Abstractpub_date
1978-09-15 00:00:00pages
39-53issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(78)91127-7journal_volume
153pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.092
更新日期:2011-04-28 00:00:00
abstract::Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90318-h
更新日期:1993-11-12 00:00:00
abstract::Numerous studies with PC12 cells have suggested that the mitogen-activated protein (MAP) kinase pathway might play a major role in the neuronal differentiation that is induced by nerve growth factor (NGF). Cells of the PC12D subline extend neurites within several hours in response to NGF in the presence of inhibitors ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01403-0
更新日期:1998-03-02 00:00:00
abstract::In the rat, calbindin-like immunoreactivity was observed at both the light and electron microscopic levels within the chemoreceptor neurons of the vomeronasal organ (VNO) and both intragemmal cells and associated nerve fibers of the circumvallate taste buds. All VNO neurons were immunoreactive. Only a subset of intrag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90493-s
更新日期:1992-02-14 00:00:00
abstract::The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90452-0
更新日期:1988-12-06 00:00:00
abstract::Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and hi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.11.053
更新日期:2005-02-09 00:00:00
abstract::Recently the nuclear proto-oncogene c-fos has been shown to be rapidly and transiently expressed following seizures in many types of epilepsies. Until now, immunohistochemical as well as in situ hybridization studies have reported that the dentate gyrus of the hippocampus and most of the cortical areas were invariably...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90988-n
更新日期:1990-06-04 00:00:00
abstract::This experiment was performed in order to examine several of the underlying mechanisms by which the septal area and adjacent regions regulate quiet biting attack behavior elicited from electrical stimulation of the hypothalamus in the cat. The results clearly indicate that stimulation of the septal area and anterior c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90147-1
更新日期:1984-09-24 00:00:00
abstract::Neuronal cells in primary culture have been demonstrated to possess specific insulin receptors (Boyd et al., J. Biol. Chem., 260 (1985) 15880-15884). Incubation of these cultures with insulin causes a dose-dependent inhibition of maprotiline-sensitive [3H]norepinephrine uptake. Maximum inhibition of 95% of maprotiline...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91242-4
更新日期:1986-11-19 00:00:00
abstract::The trace elemental concentrations, including iron, in the substantia nigra (SN) of a 6-OHDA induced rat model of Parkinson's disease were measured using nuclear microscopy. Only rats that exhibited amphetamine induced rotation of more than 7 turns/min were used. The results showed that the iron levels were significan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00313-7
更新日期:1996-09-30 00:00:00
abstract::Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04045-3
更新日期:2003-02-14 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00
abstract::Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01011-1
更新日期:1997-10-31 00:00:00
abstract::Previous studies have shown that microinjection of morphine into the prefrontal ventrolateral orbital cortex (VLO) produces antinociception. The current study examined whether gamma-aminobutyric acid (GABA) containing neurons in the VLO were involved in this antinociception. Under light anesthesia, the GABA(A) recepto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.067
更新日期:2006-02-16 00:00:00
abstract::The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90333-6
更新日期:1985-01-28 00:00:00
abstract::The pyrithiamine-treated rats produced by our method histopathologically exhibited the edematous lesion not only around the third ventricle and at the tegmentum of pons, as expected, but also in the cerebral cortex. These animals were, therefore, used in a biochemical study of the cerebral cortex, in particular, gluco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91399-6
更新日期:1988-02-16 00:00:00
abstract::Voltage-clamped GABA(A fast) and GABA(A slow) inhibitory postsynaptic currents (IPSCs) were selectively elicited in hippocampal area CA1 pyramidal neurons. Clinically relevant concentrations of halothane (1.2 vol.%) prolonged both GABA(A fast) and GABA(A slow) IPSC decay times approximately 2.5 fold, while having litt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00516-7
更新日期:1997-08-08 00:00:00
abstract::Oxytocin properties have been studied in different experimental models in order to obtain evidence for its analgesic properties. The analgesic effect of an oxytocinergic pathway descending from the hypothalamus reaching the dorsal horn of the spinal cord has been studied. In anesthetized rats, we recorded single units...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.050
更新日期:2006-04-07 00:00:00
abstract::Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats. We hypothesized that epileptogenesis can induce molecular ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.10.006
更新日期:2011-12-02 00:00:00
abstract::Event-related potentials (ERP) were measured when pleasant, neutral or unpleasant pictures were presented in the context of similarly valenced stimuli, and compared to ERPs elicited when the same pictures were viewed in an intermixed context. An early ERP component (150-300 ms) measured over occipital and fronto-centr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.072
更新日期:2008-01-16 00:00:00
abstract::Early environmental factors can modulate the development of the hypothalamic-pituitary-adrenal (HPA) axis response to stress, together with subsequent brain functions and emotional behaviors. Two rat strains, Sprague-Dawley (SD) and Fischer 344 (F344), are known to exhibit differences in HPA axis reactivity and anxiet...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.070
更新日期:2010-02-26 00:00:00
abstract::Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91599-v
更新日期:1991-10-11 00:00:00
abstract::BW 1003C87, 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid, has been tested for its in vitro and in vivo effects on glutamate release in rat brain tissue, and for its cerebro-protective action in two rodent models of cerebral ischemia. In rat brain slices the release of glutamate evoked by verat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91254-c
更新日期:1992-10-09 00:00:00
abstract::We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91575-6
更新日期:1985-05-06 00:00:00
abstract::Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 track...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91253-2
更新日期:1983-01-24 00:00:00
abstract::In humans, tendon vibration evokes illusory sensations of movement that are usually associated with an excitatory tonic response in muscles antagonistic to those vibrated (antagonist vibratory response, AVR), i.e., in the muscle groups normally contracted if the illusory movement had been performed. The aim of the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02604-4
更新日期:2000-10-27 00:00:00
abstract::Neurological problems can develop when blood glucose levels rapidly rise or fall yet there has been little experimentation at a cellular level to assess how neurophysiological change may be induced. Using intracellular recording in the rat neocortical slice preparation, we examined pyramidal neurons of layers II-III a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90859-t
更新日期:1991-07-26 00:00:00
abstract::Artificial CSF containing 12mEq/1 of potassium (4 times normal concentration) was perfused over the surface of normal neocortex in 10 locally or barbiturate anesthetized cats. Extracellular potassium concentrations ([K+]OS) were measured as a function of time to 8 h and of depth to 3 mm. Analysis of the [K+]O versus d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90265-1
更新日期:1976-01-16 00:00:00
abstract::Corticosteroids exert important effects on brain function via glucocorticoid (GRs) and mineralocorticoid receptors (MRs) by inducing receptor translocation to the nucleus, where the receptor-ligand complexes modulate transcription of target genes. Based on studies describing uneven receptor expression patterns, region...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.048
更新日期:2009-01-16 00:00:00
abstract::Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01086-5
更新日期:1998-12-14 00:00:00