Abstract：
:Voltage-clamped GABA(A fast) and GABA(A slow) inhibitory postsynaptic currents (IPSCs) were selectively elicited in hippocampal area CA1 pyramidal neurons. Clinically relevant concentrations of halothane (1.2 vol.%) prolonged both GABA(A fast) and GABA(A slow) IPSC decay times approximately 2.5 fold, while having little to no effect on current amplitudes or rise times. Current-voltage analysis revealed that IPSC reversal potentials (-70 to -75 mV) remained constant in the presence of halothane. Under control conditions, GABA(A slow) IPSC decay times increased linearly with membrane depolarization, and this IPSC decay time voltage dependence was not significantly altered by halothane. These results confirm the existence of separable GABA(A fast) and GABA(A slow) IPSCs in hippocampus, and further elucidate the effects of halothane on these currents.
journal_name
Brain Resjournal_title
Brain researchauthors
Lukatch HS,MacIver MBdoi
10.1016/s0006-8993(97)00516-7subject
Has Abstractpub_date
1997-08-08 00:00:00pages
108-12issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00516-7journal_volume
765pub_type
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