Abstract：
:BW 1003C87, 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid, has been tested for its in vitro and in vivo effects on glutamate release in rat brain tissue, and for its cerebro-protective action in two rodent models of cerebral ischemia. In rat brain slices the release of glutamate evoked by veratrine is inhibited by BW 1003C87 (IC50 = 1.6 microM). In anaesthetised rats with microdialysis probes implanted in the dorsal hippocampus the increase in extracellular glutamate evoked by veratrine is markedly reduced by co-infusion of BW 1003C87, 100 microM. In anaesthetised rats with microdialysis probes implanted in the cortex and the caudate nucleus ipsilateral to a middle cerebral artery (MCA) occlusion the increase in dialysate glutamate concentration seen in the first 2 h following MCA occlusion is markedly attenuated by the prior administration of BW 1003C87, 20 mg/kg i.v. In rats subjected to 10 min of bilateral common carotid artery occlusion the loss of CA1 pyramidal neurons (assessed 7 days later) is reduced by administration of BW 1003C87 (20 mg/kg i.v., at the time of ischemia and 4 h later). The volume of cortex showing infarction 72 h after unilateral MCA occlusion is reduced by treatment with BW 1003C87 (20 mg/kg, i.v., beginning 5 min after occlusion). Inhibition of glutamate release may provide a therapeutic approach in cerebral ischemia as well as in epilepsy.
journal_name
Brain Resjournal_title
Brain researchauthors
Meldrum BS,Swan JH,Leach MJ,Millan MH,Gwinn R,Kadota K,Graham SH,Chen J,Simon RPdoi
10.1016/0006-8993(92)91254-csubject
Has Abstractpub_date
1992-10-09 00:00:00pages
1-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)91254-Cjournal_volume
593pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Event-related brain potentials were used to study the neural mechanisms underlying goal-directed object use distinguishing between processes supporting immediate and final action goals during action planning and execution. Subjects performed a grasping and transportation task in which actions were cued either with the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.085
更新日期：2007-05-07 00:00:00
abstract：:Maternal cigarette use during pregnancy is associated with increased incidence of neural impairments in offspring, but nicotine's unique contribution to any neuropathology remains unclear, and nicotine's neurodevelopmental effects assessed in animal models vary with concentration. During ontogenesis, the chick oculomo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.070
更新日期：2004-03-12 00:00:00
abstract：:Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02938-9
更新日期：2001-11-02 00:00:00
abstract：:Effects of phenytoin (PHT) on the intracellular calcium and intracellular protein changes during pentylenetetrazole (PTZ)-induced bursting activity in the neurons of the Japanese land snail Euhadra peliomphala were examined. In the examination with a computer controlled electron probe X-ray microanalyzer, PHT clearly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91510-0
更新日期：1985-02-18 00:00:00
abstract：:Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.001
更新日期：2012-06-06 00:00:00
abstract：:An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02094-7
更新日期：2001-04-06 00:00:00
abstract：:Anisomycin is both a well-established protein synthesis inhibitor and a potent activator of the p38/JNK MAPK pathway. It has been used to block the late phase of long-term potentiation (LTP) and long-term depression (LTD) in hippocampus. In this study, we have found that anisomycin produces a time-dependent decline in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.015
更新日期：2006-04-26 00:00:00
abstract：:Ischemic stroke is caused by the interruption of cerebral blood flow that leads to brain damage with long-term sensorimotor deficits. Stem cell transplantation may recover functional deficit by replacing damaged brain. In this study, we attempted to test whether the human neural stem cells (NSCs) can improve the outco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.038
更新日期：2004-08-06 00:00:00
abstract：:Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90994-6
更新日期：1984-03-19 00:00:00
abstract：:Neurofibrillary tangles (NFTs) are a pathological hallmark of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17). However, the cellular origin and the consequence of the NFT formation are poorly un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.106
更新日期：2004-10-01 00:00:00
abstract：:In the present study, we used a repeated restraint stress animal model to observe the changes in the expression of brain-derived neurotrophic factor (BDNF) and B cell lymphoma protein-2 (Bcl-2) in hippocampal neurons of rats, monitored the time course of the expression over 3 weeks post-stress period, and examined the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.089
更新日期：2004-10-29 00:00:00
abstract：:The present study examines the brain-level representation and composition of meaning in scalar quantifiers (e.g., some), which have both a semantic meaning (at least one) and a pragmatic meaning (not all). We adopted a picture-sentence verification design to examine event-related potential (ERP) effects of reading inf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.042
更新日期：2013-01-15 00:00:00
abstract：:In order to map the recently cloned serotonin 5-HT6 receptor in the rat brain and spinal cord, polyclonal antibodies were raised against a synthetic octadecapeptide corresponding to a specific portion (Leu398-Val415) of the C-terminal domain of this receptor. Antibodies were detected by enzyme-linked immunosorbent ass...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01224-3
更新日期：1997-01-23 00:00:00
abstract：:Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.029
更新日期：2009-12-15 00:00:00
abstract：:Odor stimulation of the nose in the box turtle and the gopher tortoise produced a characteristic series of slow potentials in the olfactory bulb which were referred to as the odor evoked response. When recorded with direct coupling, the odor evoked response had 3 components: wave I, a short duration monophasic event; ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90914-2
更新日期：1975-10-24 00:00:00
abstract：:The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90019-8
更新日期：1987-09-01 00:00:00
abstract：:This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00249-2
更新日期：1998-06-08 00:00:00
abstract：:Zebrafish as a neurogenetic model system depends on the correct neuroanatomical understanding of its brain organization. Here, we address the unresolved question regarding a possible zebrafish homologue of the dorsal pallial division, the region that in mammals gives rise to the isocortex. Analyzing the distributions ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.089
更新日期：2011-03-24 00:00:00
abstract：UNLABELLED:This study examines the effects of progesterone on blood-brain barrier (BBB) integrity following thrombin administration. Thrombin is expressed in many diseases which affect neural tissue and is associated with breakdown of the BBB. Progesterone has shown protective effects on the BBB in stroke and traumatic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.04.002
更新日期：2015-07-10 00:00:00
abstract：:Monoclonal antibody N1 reacts by indirect immunofluorescence with the cell surface of tetanus toxin-positive neurons from early postnatal mouse cerebellum. In freshly trypsinized single cell suspensions from early postnatal mouse cerebellum, 5-10% of all viable cells express N1 antigen on their surface. After 3-24 h o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90136-6
更新日期：1984-07-01 00:00:00
abstract：:In addition to its stimulatory effect on prolactin release, the neuropeptide prolactin releasing peptide (PrRP) has been shown to be a mediator of the stress response. To analyze the neurochemical properties of the cells responsive to PrRP and involved in stress modulation, we examined PrRP receptor co-expression with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03183-9
更新日期：2002-10-11 00:00:00
abstract：:Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90900-8
更新日期：1994-04-11 00:00:00
abstract：:C57BL/6J (B6) and DBA/2J (D2) mice have been characterized previously as seizure-resistant and seizure-sensitive, respectively, a distinction based primarily upon a differential response to the convulsant effects of various drugs. In the present study, electroconvulsive shock (ECS) was used to assess maximal electrosh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01013-0
更新日期：1998-11-30 00:00:00
abstract：:We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02293-9
更新日期：2000-06-09 00:00:00
abstract：:Decision making is commonly conceived to reflect the interplay of mutually antagonistic systems: executive processes must inhibit affective information to make adaptive choices. Consistent with this interpretation, prior studies have shown that the dorsolateral prefrontal cortex (dlPFC) is activated by executive proce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.04.026
更新日期：2011-06-13 00:00:00
abstract：:Treatment of rat brain sections and of thalamic and striatal membranes with phosphatidylinositol phospholipase C (PIPLC), an enzyme known to hydrolyse only phosphatidylinositol and its derivatives, significantly alters the specific binding of mu- and delta-opioid ligands on their receptors. These results suggest that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90391-n
更新日期：1990-12-24 00:00:00
abstract：:A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition to and surrounding the amyloid plaques. The mechanisms by which the astrocytes become activated in AD and the consequences ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01318-8
更新日期：1998-03-02 00:00:00
abstract：:In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90598-7
更新日期：1988-10-11 00:00:00
abstract：:The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91440-0
更新日期：1988-02-23 00:00:00
abstract：:Despite the significant advances that have been made in understanding the pathophysiology of cerebral ischemia on the cellular and molecular level, only one drug, the thrombolytic tissue plasminogen activator (rt-PA), is approved by the FDA for use in patients with acute ischemic stroke. Therefore, there is a critical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.061
更新日期：2007-10-10 00:00:00
