Abstract：
:C57BL/6J (B6) and DBA/2J (D2) mice have been characterized previously as seizure-resistant and seizure-sensitive, respectively, a distinction based primarily upon a differential response to the convulsant effects of various drugs. In the present study, electroconvulsive shock (ECS) was used to assess maximal electroshock threshold (MET) in B6, D2 and hybrid mice. Results revealed that D2 mice have a significantly lower MET compared to B6 mice. There was also a significant gender effect for B6 and F2 mice with females exhibiting a lower MET compared to males. METs for F1 and F2 intercross mice were intermediate between the two parental strains. The difference in variance between F2 and F1 generation mice indicated that about three-quarters of the total variance is due to genetic influence. Taken together, results of this study suggest that the large difference in MET between B6 and D2 mice is a highly heritable trait which may yield to genetic dissection through use of quantitative trait locus mapping.
journal_name
Brain Resjournal_title
Brain researchauthors
Ferraro TN,Golden GT,Snyder R,Laibinis M,Smith GG,Buono RJ,Berrettini WHdoi
10.1016/s0006-8993(98)01013-0subject
Has Abstractpub_date
1998-11-30 00:00:00pages
207-10issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01013-0journal_volume
813pub_type
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