Abstract：
:Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded position. The latter indicated possible spontaneous pain. Sciatic nerve ligation produced significant increases in glucose utilization in the dorsal and ventral horns of both sides, with greater activity present on the ipsilateral as compared to the contralateral side. Peak activity was in laminae V-VI, a region involved in nociceptive processing. Thus, a chronic increase in neuronal activity in these regions may reflect spontaneous neuropathic pain.
journal_name
Brain Resjournal_title
Brain researchauthors
Price DD,Mao JR,Coghill RC,d'Avella D,Cicciarello R,Fiori MG,Mayer DJ,Hayes RLdoi
10.1016/0006-8993(91)91468-gsubject
Has Abstractpub_date
1991-11-15 00:00:00pages
314-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91468-Gjournal_volume
564pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91444-6
更新日期：1991-12-13 00:00:00
abstract：:The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00613-6
更新日期：1997-09-05 00:00:00
abstract：:Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90139-8
更新日期：1985-04-29 00:00:00
abstract：:Administration of benzodiazepines at appropriate times in the circadian cycle induce phase-shifts in circadian locomotor activity. The possibility that benzodiazepine-induced shifts are mediated at the level of the suprachiasmatic nuclei (SCN), identified as the circadian pacemaker in mammals, was examined electrophys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90659-j
更新日期：1991-06-21 00:00:00
abstract：:(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques. (2) Lesions of the midlateral hypothal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90189-x
更新日期：1976-05-28 00:00:00
abstract：:The present study aimed to determine whether the observation of different grasps of the same object elicits automatic imitation of the kinematics of those grasps and this process influences the estimation of intrinsic target properties. In experiments 1 and 2, participants reached and grasped differently sized spheres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.046
更新日期：2008-07-07 00:00:00
abstract：:Application of horseradish peroxidase (HRP) to the proximal stump of the transected infraorbital (IO) nerve in the orbit was employed in normal adult rats to demonstrate the ganglionic representation of and brainstem innervation by the trigeminal (V) branch which supplies primarily the mystacial vibrissae. In the V ga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90970-8
更新日期：1983-06-13 00:00:00
abstract：:The extracellular lactate concentration and blood flow in the cerebral cortex of urethane-anesthetized, paralyzed and artificially ventilated rats were monitored continuously and simultaneously using an enzyme electrode and a laser Doppler flowmeter (LDF), respectively, during chemical stimulation of the nucleus tract...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01428-x
更新日期：1997-05-30 00:00:00
abstract：:Suppression of geniculate ponto-geniculo-occipital (PGO) waves was achieved in kittens by performing bilateral mesencephalic lesions of the PGO pathways. Sleep-wake parameters and the spontaneous unit activity in the lateral geniculate nucleus (LGN) were then chronically recorded during one month after the lesions. Wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90735-9
更新日期：1987-04-14 00:00:00
abstract：:Using [3H]para-aminoclonidine, alpha 2 adrenergic binding sites have been mapped in the rat and human CNS using in vitro labeling autoradiographic techniques. In both the rat and human thoracic spinal cord, high densities of alpha 2 binding sites were associated with the substantia gelatinosa and the intermediolateral...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(84)90030-4
更新日期：1984-03-01 00:00:00
abstract：:Studies of various strains of mice revealed marked differences in their analgesic sensitivity towards morphine (mu), U50,488H (kappa 1) and naloxone benzoylhydrazone (NalBzoH; kappa 3). Sensitivity to mu and kappa analgesia varied independently of the other. Analgesic sensitivity to morphine remained relatively consis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91712-a
更新日期：1991-12-06 00:00:00
abstract：:Effect of beta-agkistrodotoxin (beta-AgTx), a presynaptic neurotoxin purified from snake venom, on large-conductance calcium-activated potassium channels (BK(Ca)) was studied in rat hippocampal CA1 pyramidal neurons using inside-out configuration of patch-clamp technique. The results showed that in equimolar K+ (150 m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02560-x
更新日期：2002-06-14 00:00:00
abstract：:Two-dimensional electrophoresis of proteins has allowed high resolution analysis of the protein species rapidly transported in the frog sciatic nerve. The 7th, 8th and 9th dorsal root ganglia were selectively labeled with [3H]leucine or [35S]methionine in one compartment of a lucite chamber. Transport of TCA-precipita...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90155-5
更新日期：1978-04-14 00:00:00
abstract：:We consider a random synaptic pruning in an initially highly interconnected network. It is proved that a random network can maintain a self-sustained activity level for some parameters. For such a set of parameters a pruning is constructed so that in the resulting network each neuron/node has almost equal numbers of i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.050
更新日期：2012-01-24 00:00:00
abstract：:During the last few years, recombinant viral vectors derived from adenovirus (Ad), adeno-associated virus (AAV) or lentivirus (LV) have been developed into highly effective vehicles for gene transfer to the adult central nervous system. In recent experiments, in the rat model of Parkinson's disease, all three vector s...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/s0006-8993(00)02915-2
更新日期：2000-12-15 00:00:00
abstract：:Event-related brain potentials were used to study the neural mechanisms underlying goal-directed object use distinguishing between processes supporting immediate and final action goals during action planning and execution. Subjects performed a grasping and transportation task in which actions were cued either with the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.085
更新日期：2007-05-07 00:00:00
abstract：:Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.017
更新日期：2006-12-18 00:00:00
abstract：:As a first step in understanding the function of the 68-kDa Alz-50 antigen (A68) in the pathophysiology of Alzheimer's disease (AD), we have reexamined preliminary observations in our laboratory (Wolozin and Davies, 1986) of a protein kinase activity associated with crude preparations of the protein. This study was un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90765-4
更新日期：1990-10-29 00:00:00
abstract：:It is well known that the nerve growth factor (NGF) may serve as a link between inflammation and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically stimulated the expression of brain-derived neurotrophic factor (BDNF) mRNA in the dorsal root ganglion (DRG). In the present study, we eva...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(97)00048-6
更新日期：1997-02-28 00:00:00
abstract：:The immunohistochemical localization of an endogenous lectin R1 isolated from the rat cerebellum was studied during its postnatal development. The lectin is present in the cerebellum from birth to adulthood, essentially in lysosomes, multivesicular bodies, and parts of the endoplasmic reticulum, principally of large a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90148-8
更新日期：1985-01-01 00:00:00
abstract：:This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00249-2
更新日期：1998-06-08 00:00:00
abstract：:In a recent study in the tiger salamander, Ambystoma tigrinum, were demonstrated topographic patterns of responsivity across the olfactory epithelium which were characteristic for each odorant. The present study was initiated to investigate whether these patterns remain constant when odorant concentration is varied. O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90562-6
更新日期：1984-04-16 00:00:00
abstract：:This study evaluated the effect of stress during puberty on sexual motivation and the correlation between serum testosterone levels (T) and the absolute power of the theta electroencephalographic rhythms, recorded in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) of adult male rats. Thirty males of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146937
更新日期：2020-10-15 00:00:00
abstract：:The characteristics of [3H]sulpiride binding to the D2 dopamine receptor in rat striatal membranes were examined under several conditions. In the absence of sodium ions, the specific binding of [3H]sulpiride could not be detected. In the direct binding experiment, at 25 degrees C, the affinity of [3H]sulpiride for D2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90040-0
更新日期：1987-02-03 00:00:00
abstract：:Leptin is one of the key afferent signals that regulate food intake and energy expenditure by acting on specific receptors in the hypothalamus. Recently, leptin was reported to activate the peripheral immune system by acting directly on lymphocytes. To elucidate the brain-mediated participation of leptin in the modula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02409-9
更新日期：2000-02-07 00:00:00
abstract：:To characterize central nervous system changes that occur with anabolic steroid abuse in humans, immunocytochemical localization of androgen receptors in the brains of 10 intact and 10 castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (AAS; 14 daily injections of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90823-6
更新日期：1993-09-17 00:00:00
abstract：:The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90374-5
更新日期：1988-09-20 00:00:00
abstract：:We have already demonstrated that, although exogenous gamma-aminobutyric acidA (GABAA) receptor agonist is capable of inhibiting the activity of luteinizing hormone releasing hormone (LHRH) pulse generator, the reduction in the endogenous GABAA receptor activity does not have a significant effect in ovariectomized rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90145-7
更新日期：1994-04-04 00:00:00
abstract：:Chronic hydrocephalus is one of the severe complications after subarachnoid hemorrhage (SAH). However, there is no efficient treatment for the prevention of chronic hydrocephalus, partially due to poor understanding of underlying pathogenesis, subarachnoid fibrosis. Transforming growth factor-β1(TGF-β1) is a potent fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.11.004
更新日期：2016-01-01 00:00:00
abstract：:Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01189-7
更新日期：1995-12-15 00:00:00
