Abstract：
:Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GAD activity was first detected at 6 weeks postlesion and was still measurable 8 months after the lesion. These results suggest that cholinergic inputs to cortex indirectly or directly influence GABAergic transmission in cortex.
journal_name
Brain Resjournal_title
Brain researchauthors
Höhmann CF,Bear MF,Ebner FFdoi
10.1016/0006-8993(85)90139-8subject
Has Abstractpub_date
1985-04-29 00:00:00pages
165-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(85)90139-8journal_volume
333pub_type
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