Abstract：
:In epilept WAG/Rij rats, multiple unit activity coinciding with the occurrence of spike-wave discharges was recorded under neurolept anesthesia. Recordings were made in the frontal cortex and in various nuclei of the thalamus, in specific nuclei such as the ventroposterolateral, the ventroposteromedial and the ventrolateral nuclei, as well as in non-specific nuclei such as the mediodorsal nucleus, the reticular thalamic nucleus, the interanteromedial nucleus and the intralaminar nuclei (the central medial nucleus, the centrolateral nucleus and the paracentral nucleus). Rhythmic unit firing concurrent with the spike component of the cortical spike-wave discharge was observed in deep layers of the cortex and in the following thalamic nuclei: in specific nuclei, the mediodorsal and the reticular thalamic nucleus. The activity in the specific nuclei and the mediodorsal nucleus shortly preceded the peak of the spike component. The burst in the reticular thalamic nucleus occurred later than in the specific nuclei. A wave-concurrent firing pattern was observed in the centrolateral nucleus and the paracentral nucleus. Cells in the central medial nucleus and interanteromedial nucleus did not fire in a phase-locked manner. Neurons in the latter nucleus, however, were generally tonically activated during the occurrence of spike-wave discharges. It is suggested that those thalamic nucleic thought to be involved in the production of cortical spindles, and that also fire concurrently with the spike component of the spike-wave discharges, are mediated in the genesis of the latter activity.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Inoue M,Duysens J,Vossen JM,Coenen AMdoi
10.1016/0006-8993(93)91641-5subject
Has Abstractpub_date
1993-05-28 00:00:00pages
35-40issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91641-5journal_volume
612pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The status of blood-brain barrier (BBB) permeability was investigated in the twitcher, an authentic murine model of globoid cell leukodystrophy (GLD, Krabbe disease) and cuprizone-intoxicated mice. Although extensive demyelination was noted in the CNS of both mice and additionally, macrophage infiltration was pronounc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90499-9
更新日期：1987-11-03 00:00:00
abstract：:A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90889-7
更新日期：1977-03-25 00:00:00
abstract：:The localization of serotonergic, various peptidergic and possibly cholinergic neurons in the medullary raphe nuclei that project to the lumbosacral spinal cord have been studied using a retrograde transport method combined with immunocytochemical and histochemical techniques. Spinally projecting neurons stained for s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90079-3
更新日期：1983-12-12 00:00:00
abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a disruption of nigrostriatal dopaminergic function which resembles parkinsonism. On the cellular level, the disruption involves a Ca2+ independent release of dopamine, depletion of nigral and striatal dopamine, and the death of dopaminergic neurons. We have p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91035-y
更新日期：1991-02-15 00:00:00
abstract：:Response conflict can be induced by priming multiple responses competing for control of action in trials. The N2 is one functionally-related cognitive control index for response conflict. And yet the underlying whiter matter neural substrates of inter-individual difference in conflict N2 remain unclear. So the aim of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.008
更新日期：2017-12-01 00:00:00
abstract：:The effects of adenosine on the voltage-sensitive delayed-rectifier K+ (IK) currents and hyperpolarization-activated cationic inward current (Ih) were studied in cultured frog melanotrophs using the whole-cell configuration of the patch-clamp technique. The A1 receptor agonist R-N6-phenylisopropyl-adenosine (R-PIA; 50...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00184-x
更新日期：1998-05-18 00:00:00
abstract：:Postnatal development of the K+-stimulated release of [3H]GABA in rat cortex slices was compared to the density of Gray type 2 synapses (which correlate with GABAergic synapses in rat cortex). The [3H]GABA release system develops earlier than the inhibitory synapses which suggests that, at least in the young cortical ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90148-7
更新日期：1983-11-01 00:00:00
abstract：:The effect of intracerebroventricular administration of dizocilpine on feeding behaviour and adrenal corticrotropic hormone (ACTH)-induced anorexia in elevated plus maze was examined. Dizocilpine (10, 20 and 40 nmol/rat, i.c.v.) showed a dose-dependent increase in food intake in 16 h food deprived rats. Dopamine recep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00990-1
更新日期：1998-11-23 00:00:00
abstract：:GEC1 protein shares high identity with GABARAP (GABA(A) Receptor-Associated Protein), interacts with tubulin and GABA(A) receptors and is potentially involved in intracellular transport processes. Recently, using quantitative real time PCR, we have reported the gec1 mRNA expression in different rat brain areas. In the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.077
更新日期：2008-05-19 00:00:00
abstract：:To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00524-t
更新日期：1995-08-14 00:00:00
abstract：:The study examined whether intravenous (i.v.) leptin increased Fos-production in spinally projecting neurons in the hypothalamic paraventricular nucleus (PVN). We combined (i) rhodamine tagged microspheres injected into the upper thoracic spinal cord and (ii) Fos (marker of neuronal activation) immunohistochemistry. E...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01902-2
更新日期：1999-10-09 00:00:00
abstract：:Inhibitory GABAergic synaptic transmission in the mammalian hippocampus depends upon a hyperpolarized reversal potential for Cl(-) (ECl). To examine the regulation of ECl hyperpolarization we cultured hippocampal neurons for two weeks in either a low- or a high-concentration of KCl (2.6 or 18.7 mM, respectively). Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.038
更新日期：2008-04-18 00:00:00
abstract：:Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was approximately 2-fold higher in only the forebrain of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00595-1
更新日期：1996-10-07 00:00:00
abstract：:Two distinct families of low-molecular-weight toxins (argiotoxins) have been isolated from the venom of the orb-web spider. Argiope trifasciata. The toxins have been purified to homogeneity and characterised by spectroscopic, mass spectrometric and microchemical analysis. The major biologically active member of the fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91098-0
更新日期：1988-05-10 00:00:00
abstract：:Transplanted embryonic stem (ES) cells can be integrated into the retinas of adult mice as well-differentiated neuronal cells. However, the integrated ES cells also have a tumorigenic effect just because they have the ability for multipotential differentiation to various types of tissues. Thus, control of neoplastic p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.079
更新日期：2006-04-26 00:00:00
abstract：:Histamine is one of the neurotransmitters suppressing appetite, but the interactions of histaminergic neurons with other neurons in satiety centers have not been clarified. Noradrenaline in the para-ventricular nucleus (PVN) has been shown to stimulate feeding. This study was designed to determine whether histamine mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01339-6
更新日期：1999-05-15 00:00:00
abstract：:Fast B neurons in bullfrog sympathetic ganglia were voltage clamped with two microelectrodes. Acetylcholine (ACh) was applied onto the soma membrane by iontophoresis. A rapid nicotinic inward current was followed by a slow muscarinic inward current. After an addition of scopolamine to Ringer solution so as to block th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90987-9
更新日期：1984-03-19 00:00:00
abstract：:The respiratory role of GABA(A), GABA(B) and glycine receptors within the Bötzinger complex (BötC) and the pre-Bötzinger complex (preBötC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nl) of GABA and gly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.032
更新日期：2010-07-16 00:00:00
abstract：:We examined the effects of chronic social stress and social rank on monamine concentrations in the prefrontal cortex (PFC) in adult male cynomolgus macaques (Macaca fascicularis). Seventy-five animals were housed in five-member social groups for 28 months and were exposed to three experimental conditions. A 'no-stress...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01146-3
更新日期：1995-12-24 00:00:00
abstract：:Abecarnil is a recently described beta-carboline which acts at central benzodiazepine receptors (BZR) and has anxioselective/anticonvulsant properties. While it may be classified provisionally as a partial agonist at BZR, there is also evidence that its pharmacological profile may be due to a selective action at BZR s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90862-4
更新日期：1992-12-18 00:00:00
abstract：:Oxidative stress in brain tissue was measured experimentally in situ using microdialysis to sample the extracellular environment for a lipid peroxidation breakdown product and antioxidants. The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic acid (AA) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01540-x
更新日期：1996-03-11 00:00:00
abstract：:Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03247-9
更新日期：2001-03-30 00:00:00
abstract：:Nerve-evoked muscle depolarisation plays an important role in the downregulation of extrasynaptic AChRs which accompanies the increase in synaptic AChR expression at the neuromuscular junction during embryonic development. However, additional mechanisms may be involved in the AChR downregulation. This study provides e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01313-4
更新日期：1999-02-13 00:00:00
abstract：:A neuron׳s response to a sound can be suppressed by the presentation of a preceding sound. It has been suggested that this suppression is a direct correlate of the psychophysical phenomenon of forward masking, however, forward suppression, as measured in the responses of the auditory nerve, was insufficient to account...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.043
更新日期：2016-05-15 00:00:00
abstract：:The immunohistochemical distribution of substance P (SP) in the hypothalamic suprachiasmatic nucleus (SCN) was studied in adult male and female Djungarian hamsters (Phodopus sungorus) held under either long or short photoperiods. Intact animals were killed by perfusion with a fixative at the middle of the light or dar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90649-1
更新日期：1994-02-28 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) activates protein kinase Akt/PKB by phosphorylation (p-Akt) which plays key roles in cell survival. In the current study, we investigated a temporal expression of p-Akt by immunohistochemical analysis after a topical application of GDNF to normal cerebral hemisphere o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03521-7
更新日期：2002-12-27 00:00:00
abstract：OBJECTIVE:The modern brain imaging studies in patients with eating disorders have shown that neurotransmitting regulation differs distinctly from control groups. These disturbances have involved serotonin and dopamine system can be inherited and conditioned by genes. The aim of this work has been the analysis of associ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.035
更新日期：2010-01-11 00:00:00
abstract：:In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90430-7
更新日期：1989-06-19 00:00:00
abstract：:To test the hypothesis that there is a functional modulation of conventional EEG bands associated with preparatory attention, putative changes in the spontaneous brain rhythms and their associated cerebral sources were addressed. The goals of the present report were, first, to find the brain areas with maximal rhythmi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.019
更新日期：2006-08-30 00:00:00
abstract：:Glycine is thought to be a major inhibitory neurotransmitter in the mammalian CNS. Two types of physiologically identified interneurons, Renshaw cells and Ia inhibitory interneurons, were intracellularly stained with horseradish peroxidase, and their axon terminals were studied at the electron microscopic level. Post-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90590-r
更新日期：1991-04-26 00:00:00
