Effects of leptin on spinally projecting neurons in the PVN of the hypothalamus.

abstract：:The effects of baclofen microinjected into the nucleus tractus solitarii (NTS) on blood pressure, heart rate and baroreflex bradycardia were studied in urethane-anesthetized rats. Baclofen caused dose-dependent pressor and tachycardic effects and inhibited the reflex bradycardia elicited by i.v. phenylephrine. The eff...

journal_title：Brain research

authors： Florentino A,Varga K,Kunos G

更新日期：1990-12-10 00:00:00

abstract：:In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and...

journal_title：Brain research

authors： Watson NV,Hargreaves EL,Penava D,Eckel LA,Vanderwolf CH

更新日期：1992-11-27 00:00:00

abstract：:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...

journal_title：Brain research

authors： Coelho JE,de Mendonça A,Ribeiro JA

更新日期：2000-06-30 00:00:00

abstract：:The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without signif...

journal_title：Brain research

authors： Danielisová V,Chavko M

更新日期：1992-09-11 00:00:00

abstract：:Experiments were conducted to examine sex differences in striatal dopamine function using in vivo microdialysis in freely moving rats. We report here a sex difference in basal extracellular striatal dopamine determined by quantitative microdialysis (the no net flux method) when castrated and ovariectomized rats were c...

journal_title：Brain research

authors： Castner SA,Xiao L,Becker JB

更新日期：1993-04-30 00:00:00

abstract：:Recently, the gene encoding the cerebrovascular and neuritic plaque amyloid, a pathologic stigma of Alzheimer's disease (AD), has been molecularly cloned and mapped to human chromosome 21, band q21. Changes in the brains of individuals with trisomy 21 (Down syndrome, DS) over 35 years of age closely resemble AD neurop...

journal_title：Brain research

authors： Reeves RH,Robakis NK,Oster-Granite ML,Wisniewski HM,Coyle JT,Gearhart JD

更新日期：1987-09-01 00:00:00

abstract：:Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root. Following this procedure, labeled neurons were found within the spinal dorsal gray matter. Analyses revealed that spinal neurons influenced by the prese...

journal_title：Brain research

authors： Sims TJ,Gilmore SA

更新日期：1997-07-18 00:00:00

abstract：:Previous neuroimaging studies provided evidence that visual mental imagery relies, in part, on the primary visual cortex. We hypothesized that, analogous to the finding that motor imagery increases the excitability of motor cortex, visual imagery should increase visual cortex excitability, as indexed by a decrease in ...

journal_title：Brain research

authors： Sparing R,Mottaghy FM,Ganis G,Thompson WL,Töpper R,Kosslyn SM,Pascual-Leone A

更新日期：2002-05-31 00:00:00

abstract：:Choline molecules are needed for the synthesis of acetylcholine and phospholipids in the mammalian brain. An enzymatic activity capable of forming lecithin (phosphatidylcholine) from the step-by-step methylation of phosphatidylethanolamine is identified in the bovine brain. This enzyme(s), phosphatidylethanolamine-N-m...

journal_title：Brain research

authors： Blusztajn JK,Zeisel SH,Wurtman RJ

更新日期：1979-12-28 00:00:00

abstract：:Horeradish peroxidase was injected at multiple sites in the mandibular and sublingual salivary glands in order to label the preganglionic salivatory neurons in the brain stem. The same injections resulted in retrograde labeling of the sympathetic and sensory neurons that project to these glands. Labeled fusiform and m...

journal_title：Brain research

authors： Chibuzo GA,Cummings JF

更新日期：1980-05-12 00:00:00

abstract：:Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To investigate the effects of post-HI hypothermia on IL-18 in the developing brain, 7-day-old rats were subjected to left ca...

journal_title：Brain research

authors： Fukui O,Kinugasa Y,Fukuda A,Fukuda H,Tskitishvili E,Hayashi S,Song M,Kanagawa T,Hosono T,Shimoya K,Murata Y

更新日期：2006-11-22 00:00:00

abstract：:The effects of hyperbaric oxygen have been studied on synaptic transmission in the hippocampal brain slice. Oxygen enhances both the prevolley and postsynaptic potential of extracellularly recorded responses following focal stimulation of afferent fiber bundles, but synaptic efficiency is reduced. It is suggested that...

journal_title：Brain research

authors： King GL,Parmentier JL

更新日期：1983-01-31 00:00:00

abstract：:Alcohol-preferring Alko, Alcohol (AA) rats with free access to food and water were taught to voluntarily consume 10% alcohol solution during 20-min sessions. After the drinking session, rats had elevated dopamine release (as reflected by 3-methoxytyramine concentrations) in the nucleus accumbens, olfactory tubercle, a...

journal_title：Brain research

authors： Honkanen A,Ahtee L,Korpi ER

更新日期：1997-11-07 00:00:00

abstract：:4-Aminopyridine (4-AP), bicuculline and GABA were applied locally to dorsal horn cells in the lumbar spinal cord in Nembutal-anaesthetized cats and in spinal cats. 4-AP expanded the cutaneous receptive field of 29 of 33 cells tested. Bicuculline and GABA had little or no effect on receptive field size. ...

journal_title：Brain research

authors： Saadé N,Jabbur SJ,Wall PD

更新日期：1985-10-07 00:00:00

abstract：:NO (nitric oxide) produced in limbic brain regions has important roles in the regulation of autonomic nervous system and HPA axis activity, anxiety, fear learning, long-term memory formation, and depression. NO is synthesized from l-arginine in a reaction catalyzed by nitric oxide synthase (NOS). Neuronal nitric oxide...

journal_title：Brain research

authors： Keser A,Balkan B,Gozen O,Kanit L,Pogun S

更新日期：2011-01-12 00:00:00

abstract：:Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. W...

journal_title：Brain research

authors： Dias Soares D,Fernandez F,Aguerre S,Foury A,Mormède P,Chaouloff F

更新日期：2003-01-24 00:00:00

abstract：:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the...

journal_title：Brain research

authors： Moon C,Ahn M,Wie MB,Kim HM,Koh CS,Hong SC,Kim MD,Tanuma N,Matsumoto Y,Shin T

更新日期：2005-02-28 00:00:00

abstract：:Dexmedetomidine (Dex) has the neuroprotective effect on cerebral ischemia-reperfusion injury (CIRI). But the mechanism is not yet clear. In this study, we established a model of middle cerebral artery occlusion (MCAO) and treated primary cortical neurons with oxygen glucose deprivation (OGD), followed by Dex treatment...

journal_title：Brain research

authors： Liu C,Fu Q,Mu R,Wang F,Zhou C,Zhang L,Yu B,Zhang Y,Fang T,Tian F

更新日期：2018-12-15 00:00:00

abstract：:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the ...

journal_title：Brain research

authors： Kuno T,Tanaka C

更新日期：1981-12-28 00:00:00

abstract：:The locus coeruleus of the adult albino rat is a clearly delimited nucleus in Nissl-stained preparations. It is surrounded by an extensive, relatively neuron-free neuropil which is not stained in reduced silver and Luxol fast blue preparations. Most if not all locus coeruleus neurons contain the enzyme dopamine-beta-h...

journal_title：Brain research

authors： Swanson LW

更新日期：1976-06-25 00:00:00

abstract：:Dissociated striatal neurons exhibited increased neurite outgrowth when co-cultured with myenteric plexus explants. Enriched enteric neurons or enriched enteric glia produced a less marked response; non-ganglionic cells had no effect. Increases in striatal neuron and glial cell numbers were seen in all co-cultures. Te...

journal_title：Brain research

authors： Höpker VH,Saffrey MJ,Burnstock G

更新日期：1994-06-20 00:00:00

abstract：:Endogenous calcitonin was altered in rats by thyroparathyroidectomy, followed by supplementation with thyroxine and calcium. As a result, a reduction in the content of 5-hydroxytryptamine in the brain together with an increase in the concentration of tryptophan in the plasma were observed. The changes were accompanied...

journal_title：Brain research

authors： Nakhla AM,Latif A

更新日期：1982-04-29 00:00:00

abstract：:The alpha7 nicotinic receptor agonist 3-[2,4-dimethoxybenzylidene]anabaseine (DMXB; GTS-21) was investigated for its ability to: (1) activate a variety of nicotinic receptor subtypes in Xenopus oocytes; (2) improve passive avoidance and spatial Morris water task performances in mecamylamine-sensitive manners in bilate...

journal_title：Brain research

authors： Meyer EM,Tay ET,Papke RL,Meyers C,Huang GL,de Fiebre CM

更新日期：1997-09-12 00:00:00

abstract：:Cell death was due to activation of the receptor responsive to N-methyl-D-aspartate (NMDA). Even during a 30-min incubation, glutamate toxicity was unaffected by 5 microM CNQX and was greater than 90% blocked by 160 nM MK-801, a specific antagonist of the NMDA receptor. The extent of toxicity was dependent on the age ...

journal_title：Brain research

authors： Eimerl S,Schramm M

更新日期：1991-09-27 00:00:00

abstract：:The role of periventricular tissue surrounding the anteroventral third ventricle (AV3V) in mediating drinking behavior induced by angiotensin II was investigated rats. Electrolytic lesions which bilaterally destroyed preoptic-hypothalamic periventricular tissue surrounding AV3V abolished drinking responses normally el...

journal_title：Brain research

authors： Buggy J,Johnson AK

更新日期：1978-06-23 00:00:00

abstract：:In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied gamma-aminobutyric acid (GABA) and glutamate were monitored before, dur...

journal_title：Brain research

authors： Smith SS,Waterhouse BD,Chapin JK,Woodward DJ

更新日期：1987-01-06 00:00:00

abstract：:Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...

journal_title：Brain research

authors： Deak T,Nguyen KT,Cotter CS,Fleshner M,Watkins LR,Maier SF,Spencer RL

更新日期：1999-11-20 00:00:00

abstract：:In anesthetized, artificially ventilated cats, pretreated with the muscarinic antagonist scopolamine, the effect of naloxone on the efficacy of nicotinic transmission in the superior cervical ganglion was used as a test of endogenous opioid release by the preganglionic axons. The cervical sympathetic trunk (CST) was s...

journal_title：Brain research

authors： Zhang C,Bachoo M,Polosa C

更新日期：1991-05-10 00:00:00

abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...

journal_title：Brain research

authors： Furlong T,Carrive P

更新日期：2007-01-12 00:00:00

abstract：:We sought to further elucidate signal transduction pathways for the I(1)-imidazoline receptor in PC12 cells and their interaction with the well-characterized signaling events triggered by nerve growth factor (NGF) in these cells. Stimulation of the I(1)-imidazoline receptor with moxonidine, a centrally acting antihype...

journal_title：Brain research

authors： Edwards L,Ernsberger P

更新日期：2003-08-01 00:00:00