Abstract：
:The status of blood-brain barrier (BBB) permeability was investigated in the twitcher, an authentic murine model of globoid cell leukodystrophy (GLD, Krabbe disease) and cuprizone-intoxicated mice. Although extensive demyelination was noted in the CNS of both mice and additionally, macrophage infiltration was pronounced in the twitcher, BBB remained intact to horseradish peroxidase. Thus, the change of microenvironment caused by demyelination is not necessarily a responsible factor for increased BBB permeability in the inflammatory demyelinating conditions.
journal_name
Brain Resjournal_title
Brain researchauthors
Kondo A,Nakano T,Suzuki Kdoi
10.1016/0006-8993(87)90499-9subject
Has Abstractpub_date
1987-11-03 00:00:00pages
186-90issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)90499-9journal_volume
425pub_type
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