Direct mapping of beta-adrenergic receptors in the rat central nervous system by a novel fluorescent beta-blocker.

abstract：:The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...

journal_title：Brain research

authors： Graybiel AM

更新日期：1975-10-10 00:00:00

abstract：:Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the mechanisms underlying this symptom, it was studied and compared in rat models of systemic and local hyperglycemia. Systemic hyperglycemia was induced by a single injection of streptozotocin (STZ, 50 mg/kg). Local hyperglycemia either i...

journal_title：Brain research

authors： Dobretsov M,Hastings SL,Romanovsky D,Stimers JR,Zhang JM

更新日期：2003-01-17 00:00:00

abstract：:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...

journal_title：Brain research

authors： Watanabe M,Shimizu K,Kodama Y,Takishima K,Mamiya G,Ichinowatari N

更新日期：1995-01-23 00:00:00

abstract：:We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. ...

journal_title：Brain research

authors： Cavalheiro EA,Bortolotto ZA,Turski L

更新日期：1987-05-19 00:00:00

abstract：:Alteration in the blood-nerve barrier may be of primary importance in the development of experimental lead neuropathy. Using quantitative track autoradiography, we have directly demonstrated that there is a 15-fold increase in the rate of 210Pb accumulation in the endoneurium 70 days after the onset of chronic intoxic...

journal_title：Brain research

authors： Windebank AJ,Dyck PJ

更新日期：1981-11-23 00:00:00

abstract：:Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...

journal_title：Brain research

authors： Zhang Y,Wang M,Li H,Zhang H,Shi Y,Wei F,Liu D,Liu K,Chen D

更新日期：2012-06-06 00:00:00

abstract：:In cats ranging in age from the second week to adult, the postnatal functional development of striate cortical neurons projecting to the superior colliculus (SC) was studied by observing their visual responses, axonal conduction velocities and spontaneous activities. One-hundred-and-fifty-seven cells were identified a...

journal_title：Brain research

authors： Tsumoto T,Suda K

更新日期：1983-12-01 00:00:00

abstract：:The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...

journal_title：Brain research

authors： Leclerc R,Pelletier G

更新日期：1977-07-01 00:00:00

abstract：:Repeated doses of estradiol benzoate (10 micrograms/kg, s.c., once a day for 2, 5 or 8 days) to male rats decreased gamma-aminobutyric acid (GABA) content and glutamate decarboxylase (GAD) activity in substantia nigra (SN) but failed to change these parameters in hippocampus, cerebral cortex, cerebellum, lateral septu...

journal_title：Brain research

authors： Nicoletti F,Meek JL

更新日期：1985-04-15 00:00:00

abstract：:The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually ...

journal_title：Brain research

authors： Ichikawa H,Hidaka H,Sugimoto T

更新日期：2000-05-02 00:00:00

abstract：:Many lines of evidence support the importance of the nucleus accumbens (NAC) for ethanol-reinforced behavior. The nature of the neuronal activity that occurs in this region during ethanol self-administration is not known. We recorded from ensembles of single-units primarily located within the shell of the NAC during o...

journal_title：Brain research

authors： Janak PH,Chang JY,Woodward DJ

更新日期：1999-01-30 00:00:00

abstract：:Norepinephrine (NE), acting on brain adrenoceptors, plays an important role in barrel field neuronal activity and plasticity. For this reason, the distribution of alpha 1- and alpha 2-adrenoceptors in the somatosensory cortex barrel field was studied by autoradiographic techniques in rats undergoing plastic change or ...

journal_title：Brain research

authors： Dunn-Meynell AA,Levin BE

更新日期：1993-09-24 00:00:00

abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...

journal_title：Brain research

authors： Li J,Wurtman RJ

更新日期：1999-02-13 00:00:00

abstract：:The intracellular free Ca2+ concentration ([Ca2+]i) of the bullfrog sympathetic ganglion cell was measured with fura-2 fluorescence under various conditions, and compared with changes in membrane potential recorded with an intracellular electrode. The [Ca2+]i was 109 nM on average under the resting condition and incre...

journal_title：Brain research

authors： Nohmi M,Kuba K,Ogura A,Kudo Y

更新日期：1988-01-12 00:00:00

abstract：:Neuronal expression of brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of infarct tolerance (resistance to stroke) (H. Yanamoto et al., Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei, submitted to Brain Res.), a process that takes more than 7 days fol...

journal_title：Brain research

authors： Yanamoto H,Nagata I,Sakata M,Zhang Z,Tohnai N,Sakai H,Kikuchi H

更新日期：2000-03-24 00:00:00

abstract：:In a whole mount preparation of the hooded rat retina, stained with methylene blue, the ganglion cell density was counted over the retina. The density ranged from 6200-6500/sq.mm to 1000-1500/sq.mm. The area with a density higher than 6000/sq.mm was called the central area and was centered at about 1 mm (20 degrees) a...

journal_title：Brain research

authors： Fukuda Y

更新日期：1977-01-07 00:00:00

abstract：:Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...

journal_title：Brain research

authors： Wada N,Takayama R,Kanda K,Tokuriki M

更新日期：1998-03-30 00:00:00

abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...

journal_title：Brain research

authors： Wigley CB,Berry M

更新日期：1988-07-01 00:00:00

abstract：:Unit activity of locus coeruleus (LC) neurons in rats was investigated. After the animal recovered from anesthesia, the spontaneous activity exhibited periodic bursting discharges at about 15-30 s intervals. The oscillation was observed to last for a long time (1-3 h). It is suggested that many LC neurons exhibited th...

journal_title：Brain research

authors： Akaike T

更新日期：1982-05-13 00:00:00

abstract：:Early environmental factors can modulate the development of the hypothalamic-pituitary-adrenal (HPA) axis response to stress, together with subsequent brain functions and emotional behaviors. Two rat strains, Sprague-Dawley (SD) and Fischer 344 (F344), are known to exhibit differences in HPA axis reactivity and anxiet...

journal_title：Brain research

authors： Uchida S,Hara K,Kobayashi A,Otsuki K,Hobara T,Yamagata H,Watanabe Y

更新日期：2010-02-26 00:00:00

abstract：:One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]p...

journal_title：Brain research

authors： Meyer RL

更新日期：1983-02-01 00:00:00

abstract：:To investigate whether differences in vulnerability to free radicals might underlie differences among striatal neurons in their vulnerability to neurodegenerative processes such as occur in ischemia and Huntington's disease, we have analyzed the localization of superoxide free radical scavengers in different striatal ...

journal_title：Brain research

authors： Medina L,Figueredo-Cardenas G,Reiner A

更新日期：1996-02-05 00:00:00

abstract：:Auditory working memory (WM) is the cognitive faculty that allows us to actively hold and manipulate sounds in mind over short periods of time. We develop here a particular perspective on WM for non-verbal, auditory objects as well as for time based on the consideration of possible parallels to visual WM. In vision, t...

journal_title：Brain research

authors： Joseph S,Teki S,Kumar S,Husain M,Griffiths TD

更新日期：2016-06-01 00:00:00

abstract：:We have previously found that the amyloid precursor protein (APP) of Alzheimer's disease is present on the surface of rat cortical neurons in culture, in a segmental pattern which first becomes evident after 24 hours and is fully developed by five days. As APP has previously been reported to have a short half-life in ...

journal_title：Brain research

authors： Storey E,Spurck T,Pickett-Heaps J,Beyreuther K,Masters CL

更新日期：1996-09-30 00:00:00

abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...

journal_title：Brain research

authors： Cohen I,Van der Kloot W

更新日期：1982-06-10 00:00:00

abstract：:The blockade of central histaminergic H(2) receptors has been reported to aggravate ischemic neuronal damage. Since excess release of excitatory neurotransmitters is closely related to ischemic neuronal damage, the effects of ranitidine on ischemic release of dopamine were investigated in gerbil striatum. Changes in t...

journal_title：Brain research

authors： Adachi N,Terao K,Otsuka R,Arai T

更新日期：2002-02-01 00:00:00

abstract：:This study examined the behavioral effects of agents active at the gamma-aminobutyric acid (GABA(A)) receptor complex in the mouse staircase paradigm. The neuroactivesteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were compared with the benzodiazepine agonist clonazepam, the non-benz...

journal_title：Brain research

authors： Weizman R,Paz L,Peter Y,Toren P,Pick CG

更新日期：2001-05-18 00:00:00

abstract：:In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the lef...

journal_title：Brain research

authors： Jeye BM,MacEvoy SP,Karanian JM,Slotnick SD

更新日期：2018-05-15 00:00:00

abstract：:The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of...

journal_title：Brain research

authors： Wen GY,Wisniewski HM,Kascsak RJ

更新日期：1999-06-19 00:00:00

abstract：:Two distinct serotonin receptors in mammalian brain are labeled respectively with [3H]serotonin (5-HT1) and [3H]spiperone (5-HT2). In general agonists display highest affinities for 5-HT1 while antagonists prefer 5-HT2 sites. To conduct regional studies of 5-HT receptors, we estimated 5-HT2 sites with [3H]spiperone, u...

journal_title：Brain research

authors： Peroutka SJ,Snyder SH

更新日期：1981-03-16 00:00:00