Abstract：
:Neonatal rat superior cervical ganglia were mechanically dissociated, and the sympathetic neurons grown in dispersed cell cultures. Intracellular microelectrodes were used to study the effects of tetraethylammonium (TEA+), a blocker of outward K+ currents, on the excitable properties of these neurons. Addition of TEA+ to the perfusion media (TEA+-media) caused the resting potential to depolarize and the action potential to increase in duration. In TEA+-media (20-60 mM), a late delayed depolarization (LDD) followed the falling phase of the action potential with a delay of 1.5-2 s (n = 95). The LDD peak amplitude was in the range of 4-26 mV and the duration, to full return of the resting potential, was in the range of 18-90 s. For a given cell the amplitude and duration of the LDD were constant. The LDD was associated with a conductance increase. No LDD could be elicited in the presence of calcium channel blockers. Evidence was found for a Ca2+-dependence of the LDD: increasing the extracellular Ca2+ concentration caused increases in the amplitude and duration of the LDD. The significance of an endogenous LDD-like potential and possible explanations for the origin of the LDD are discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Suppes Tdoi
10.1016/0006-8993(84)91234-4subject
Has Abstractpub_date
1984-02-20 00:00:00pages
269-78issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)91234-4journal_volume
293pub_type
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