Abstract:
:Experiments were performed in the male Wistar rat to investigate the projections from cardiovascular responsive sites in the ventrolateral medulla (VLM) to the subfornical organ (SFO). Unilateral iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHA-L) were made into either caudal VLM (CVLM) sites at which microinjection of l-glutamate (10 nl; 0.25 M) elicited decreases in mean arterial pressure or into rostral VLM (RVLM) sites at which l-glutamate microinjection elicited increases in arterial pressure. After a survival period of 7-10 days, transverse sections of the forebrain and brainstem were processed for PHA-L immunoreactivity. After injections of PHA-L into the CVLM, axonal and presumptive terminal labeling was found bilaterally throughout the rostrocaudal extent of the SFO, although most of the projections were observed within the rostral half of the nucleus. Within the SFO, labeling was found primarily in the lateral aspects of the nucleus, often in close proximity to blood vessels. In addition, CVLM injections resulted in labeling within the organum vasculosum of the laminae terminalis (OVLT) and within the ventral and dorsal components of the median preoptic nucleus (MnPO) bilaterally, but with an ipsilateral predominance. In contrast, PHA-L injections into the RVLM did not result in axonal labeling in the SFO or OVLT, although a few labeled axons were found to course through the region of the ventral component of MnPO. These data have demonstrated that neurons within the cardiovascular responsive region of the CVLM send direct axonal projections to the SFO and other structures of the laminae terminalis, and suggest that the CVLM may function in the modulation of the activity of neurons of circumventricular organs to intra- and extracellular signals of body fluid balance.
journal_name
Brain Resjournal_title
Brain researchauthors
Babic T,Roder S,Ciriello Jdoi
10.1016/j.brainres.2003.12.029subject
Has Abstractpub_date
2004-04-02 00:00:00pages
113-21issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304000794journal_volume
1003pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in norma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00783-5
更新日期:1998-11-09 00:00:00
abstract::A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.014
更新日期:2007-12-05 00:00:00
abstract::The effects of divalent and trivalent cations on the gamma-aminobutyric acid (GABA)-induced chloride current were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell configuration of the patch-clamp technique. Lanthanum (La3+) reversibly potentiated the GABA-induced current with a hal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91510-y
更新日期:1993-04-02 00:00:00
abstract::Antisense oligodeoxynucleotides (ODNs) are used for the selective inhibition of gene expression. Antisense ODNs are promising tools for the investigation of physiological implications of proteins in the central nervous system of rodents in vivo. We have previously demonstrated that a phosphorothioate antisense ODN to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00463-0
更新日期:1997-08-08 00:00:00
abstract::In gerbils pentylenetetrazole- or handling-induced seizures were accompanied by cerebral formation of small amounts of cysteinyl-leukotrienes (LT) but large amounts of prostaglandin (PG) F2 alpha. By contrast, in rats injected with pentylenetetrazole or bicuculline very large amounts of PGF2 alpha but no cysteinyl-LT ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90519-2
更新日期:1991-02-01 00:00:00
abstract::Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91273-j
更新日期:1990-01-08 00:00:00
abstract::A hemodynamic mechanism has long been assumed to play an important role in watershed infarction. In recent years, however, clinical evidence has indicated that an embolic mechanism is involved. The mechanism by which emboli are trapped preferentially in watershed areas remains unclear. In the present study, we develop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.11.028
更新日期:2018-01-15 00:00:00
abstract::Synaptic membrane (SM) and postsynaptic density (PSD) fractions isolated from the cerebral cortex (CTX) and cerebellum (CL) of the canine brain were found to contain one class of specific nitrendipine binding sites. The specific binding constants were: CTX-SM, Kd = 110 pM (Bmax = 126 fmol/mg protein); CTX-PSD, Kd = 20...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(86)90008-2
更新日期:1986-11-01 00:00:00
abstract::Our previous studies have indicated that oxygen radicals, produced during reoxygenation following short-term arterial hypoxia, lead to sustained suppression of cerebral arteriolar responses to N-methyl-D-aspartate (NMDA). However, whether arteriolar dilator responses to NMDA are reduced during arterial hypoxia has nev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01196-7
更新日期:1998-01-12 00:00:00
abstract::We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00033-x
更新日期:1998-03-30 00:00:00
abstract::This study was performed to understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.09.076
更新日期:2008-12-09 00:00:00
abstract::Depolarizing actions of 4 conformationally restricted L-glutamate analogues, (2S,3S,4S) isomer (L-CCG-I), (2S,3R,4R) isomer (L-CCG-II), (2S,3S,4R) isomer (L-CCG-III) and (2S,3R,4S) isomer (L-CCG-IV) of L-alpha-(carboxycyclopropyl)-glycine (L-CCG), were investigated in the isolated rat spinal cord by extracellular reco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90207-2
更新日期:1989-02-20 00:00:00
abstract::Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.02.011
更新日期:2014-03-27 00:00:00
abstract::Butyrate treatment results in the rapid formation of processes on F98 anaplastic glioma cells. The morphological differentiation occurs more rapidly and to a greater extent than that induced by nerve growth factor (NGF). The incorporation of [3H]thymidine is virtually stopped 1 day after treatment of F98 cells with so...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90109-2
更新日期:1982-09-01 00:00:00
abstract::Understanding the structural and functional development of neurons in networks has a high impact to estimate the potentials for restorative therapies. Neurons derived from the human NT2 cell line (hNT) formed networks with a clustered neuritic architecture in vitro, whereas primary dissociated embryonic rat cortical n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.076
更新日期:2004-08-20 00:00:00
abstract::Several neurodevelopmental disorders, including schizophrenia, autism, ADD/ADHD and dyslexia are believed to originate during gestation and involve white matter abnormalities. Modulation of glutamate environments and glutamate receptors has also been implicated in alteration of oligodendrocytes, the myelin forming cel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.126
更新日期:2008-10-09 00:00:00
abstract::Ongoing electrical activity was recorded from the axons of neurosecretory cells from the brain of 5th instar Rhodnius prolixus throughout the moulting cycle. Dramatic changes in both the frequency and pattern of electrical activity occur at specific times during the cycle, enabling the timing of release of neurohormon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90314-5
更新日期:1980-06-02 00:00:00
abstract::Preganglionic sympathetic neurons were labelled by retrograde transport of horseradish peroxidase, while catecholamine axon varicosities were marked by the uptake of 5-hydroxydopamine in the intermediolateral nucleus of the rat. The direct synaptic contacts from the catecholamine axons to the preganglionic sympathetic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90246-5
更新日期:1986-08-20 00:00:00
abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.024
更新日期:2019-07-15 00:00:00
abstract::Human subjects were asked to perform sinusoidal tracking movements (0.5--3.0 Hz) with their forearms while external torque disturbances were applied at the elbow. The changes in angular position, velocity, and acceleration produced by these disturbances were found to be represented in the reflex changes in EMG activit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90946-4
更新日期:1980-07-07 00:00:00
abstract::It is well established that autonomic control of digestive function is modulated by central autonomic neurotransmission. In this context it has been shown that digestive function can be modulated by exogenous neuropeptides microinjected into specific brain sides. Furthermore, there is considerable evidence suggesting ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.12.034
更新日期:2005-03-02 00:00:00
abstract::In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90693-x
更新日期:1982-12-16 00:00:00
abstract::In spite of the numerous reports on the optic fiber distribution in the optic nerve and tract of vertebrates, there have been few studies of the visual pathway in reptiles. The arrangement of fibers in the optic nerve and tract of the turtle Mauremys leprosa was studied by placing a small granule of carbocyanine dye (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.016
更新日期:2007-12-01 00:00:00
abstract::The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell count...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02323-4
更新日期:2000-06-23 00:00:00
abstract::Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90834-3
更新日期:1975-01-17 00:00:00
abstract::Rodent models of focal and global ischemia were used to examine caspase activation. Several readouts were employed on identical tissue to provide correlative measurement of caspase induction, activation and enzymatic activity. In a rat focal ischemia model, caspase-3 enzymatic activity, as recorded by DEVD-AMC cleavag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02846-4
更新日期:2003-08-29 00:00:00
abstract::We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01505-9
更新日期:1998-03-16 00:00:00
abstract::Noxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. The aim ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.057
更新日期:2011-05-19 00:00:00
abstract::Recent studies stressed the importance of comparing exemplars both for improving performance by artificial classifiers as well as for explaining human category-learning strategies. In this report we provide a theoretical analysis for the usability of exemplar comparison for category-learning. We distinguish between tw...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.079
更新日期:2008-08-15 00:00:00
abstract::Pharmacological studies using an in vitro model system were carried out to determine if naloxone, an opiate receptor antagonist, could have effects on neuronal membranes which were unrelated to its action as an opiate receptor antagonist. Intracellular recordings were made from cultured mammalian spinal cord neurons. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90747-7
更新日期:1980-10-06 00:00:00