Abstract：
:The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell counting of TH-immunoreactive perikarya of the SNc, paranigral (PN) and interfascicular (IF) nucleus was performed and compared. Our findings demonstrate that E eliminated TH immunoreactivity from a number of midbrain neurons, while it seemingly did not affect it in others. This signifies a differential effect of E on ventral mesencephalic dopaminergic neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Zsarnovszky A,Scalise TJ,Horvath TL,Naftolin Fdoi
10.1016/s0006-8993(00)02323-4subject
Has Abstractpub_date
2000-06-23 00:00:00pages
363-6issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02323-4journal_volume
868pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.085
更新日期：2007-01-26 00:00:00
abstract：:Glutamate kills sensitive neurons through several steps downstream to receptor activation: increased free Ca2+ levels, activation of various enzymes and accumulation of reactive oxygen species (ROS). We have evaluated in a well established model of neuronal cultures the neuroprotective effects of blocking these mechan...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-07-22 00:00:00
abstract：:In animals with retinal degeneration, the presence of activated microglial cells in the outer retina during the early stages of injury suggests that they may be involved in the ensuing photoreceptor cell death. In the following study, we investigated the effects of rat retina-derived microglial cells on a photorecepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01625-x
更新日期：1999-07-31 00:00:00
abstract：:The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats hav...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91070-x
更新日期：1986-10-22 00:00:00
abstract：:Full limbic seizures were kindled in rats by repeated, bi-daily microinjections of glutamate (1.5 mumol) into the basolateral amygdala. Co-administration of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid with the glutamate, prevented the development of both electroencephalographi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91279-p
更新日期：1990-01-08 00:00:00
abstract：:The density of specific prostaglandin E2 (PGE2) binding sites was quantitatively mapped in the rat brain using in vitro autoradiography. The anterior wall of the third ventricle and the nucleus solitary tract were found to have a very high density of binding sites (greater than 15 fmol/mg tissue). Two thalamic nuclei ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90720-t
更新日期：1992-05-29 00:00:00
abstract：:A simple pressure injection technique was developed to deliver substances into specific regions of the embryonic and neonatal mouse brain in vivo. The retrograde tracers Fluorogold and cholera toxin B subunit were used to test the validity of the technique. Injected animals survived the duration of transport (24-48 h)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.024
更新日期：2010-01-11 00:00:00
abstract：:The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.064
更新日期：2009-08-04 00:00:00
abstract：:Inbred mouse strains differed significantly in sensitivity to convulsions induced by 9 convulsant drugs administered using a timed infusion procedure. Some strains (e.g. BALB/cJ, A/J) were generally seizure-susceptible, while some were generally seizure resistant (e.g. C57BL/6J, SWR/J). However, the overall pattern of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90243-5
更新日期：1990-08-27 00:00:00
abstract：:The cholinergic presynaptic terminals of Torpedo electric organ have been examined morphometrically following stimulation by KCI and sucrose. The objective was to confirm correlations predicted by the vesicle hypothesis between miniature end-plate potentials (MEPPs) and morphometric changes in terminal ultrastructure....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00109-1
更新日期：1997-04-25 00:00:00
abstract：:In order to investigate protein function in rat primary cortical neuronal cultures, we modified an adenoviral vector expression system and assessed the strength and specificity of the cytomegalovirus (CMV), rous sarcoma virus (RSV), and rat and human synapsin 1 (SYN1) promoters to drive DsRed-X expression. We also inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.089
更新日期：2006-08-02 00:00:00
abstract：:The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90137-7
更新日期：1982-07-01 00:00:00
abstract：:Immunohistochemical localization of the decapeptide gonadotropin releasing hormone (GnRH) in neural structures in the pony brain and infundibulum (INF) was conducted at the light-microscopic level. This procedure utilized an antiserum generated against GnRH conjugated to bovine serum albumin. In the rostral INF, GnRH ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90625-9
更新日期：1981-03-09 00:00:00
abstract：:The present study examined the influences of dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of Sprague-Dawley rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA). It has been proposed that the neonatal 6-OHDA-lesioned rat could se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90305-3
更新日期：1989-10-23 00:00:00
abstract：:Pouch young opossums aged from 5 to 34 days underwent unilateral eye enucleation and the projection from the remaining eye to the superior colliculus (SC) was explored at maturity by anatomical and physiological methods. The results were compared to data from normal or adult enucleated animals. Analysis of the experim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90236-1
更新日期：1986-06-01 00:00:00
abstract：:Peripheral nerve injury induces changes in gene expressions of a variety of neuroactive substances in cell somata, which may have roles in the adaptive response to the injury, neuronal survival, growth and regeneration. In this study, we designed a rat model of ischemic peripheral facial paralysis with a selective emb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03319-9
更新日期：2001-03-02 00:00:00
abstract：:Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently bloc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91633-4
更新日期：1993-08-13 00:00:00
abstract：:The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90107-x
更新日期：1984-08-01 00:00:00
abstract：:The central nucleus of the inferior colliculus (IC) is a laminated structure that receives multiple converging afferent projections. These projections terminate in a layered arrangement and are aligned with dendritic arbors of the predominant disc-shaped neurons, forming fibrodendritic laminae. Within this structural ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.055
更新日期：2007-10-10 00:00:00
abstract：:Three experiments were conducted to test the hypothesis that brain corticotropin-releasing hormone (CRH) systems mediate stress-induced freezing behavior, an index of a rat's level of fear. We administered i.c.v. 0-50 micrograms of alpha-helical CRH9-41 (a specific CRH antagonist) before foot shock and showed that thi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90064-9
更新日期：1988-08-02 00:00:00
abstract：:The effects of adenosine on the voltage-sensitive delayed-rectifier K+ (IK) currents and hyperpolarization-activated cationic inward current (Ih) were studied in cultured frog melanotrophs using the whole-cell configuration of the patch-clamp technique. The A1 receptor agonist R-N6-phenylisopropyl-adenosine (R-PIA; 50...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00184-x
更新日期：1998-05-18 00:00:00
abstract：:Excitatory transmission along the perforant path from the entorhinal cortex to the granule cells of the dentate gyrus was evaluated two days after 10 min of transient cerebral ischemia in the rat. The amplitude of the population spike, and the amplitude and the initial slope of the population excitatory postsynaptic p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91446-7
更新日期：1989-12-29 00:00:00
abstract：:To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.032
更新日期：2005-05-31 00:00:00
abstract：:Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.022
更新日期：2009-02-23 00:00:00
abstract：:Neurotensin-producing perikarya and fibers have been identified in the ventral tegmental area of the rat, and recent microinjection studies indicate that neurotensin may function in the ventral tegmental area to regulate body temperature. In this study, the hypothermic response produced by intraventral tegmental injec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90031-9
更新日期：1985-02-11 00:00:00
abstract：:The Timm and selenium staining techniques, based on silver amplification of endogenous zinc, produce an electron-dense precipitate in boutons. The staining characteristics of the two methods were compared by examining two allocortical regions, prepiriform cortex and entorhinal cortex, in the brain of the European hedg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90361-0
更新日期：1985-11-25 00:00:00
abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90142-x
更新日期：1990-11-26 00:00:00
abstract：:The origin of the afferents of the thalamic anterior paraventricular and parataenial nuclei (PVA-PT) in the rat was studied with fluorescent retrograde tracing method. After iontophoretic application of Fluoro-Gold into PVA-PT, many labeled cells were found in the medial frontal cortex, ventral subiculum, claustrum, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91570-7
更新日期：1990-07-02 00:00:00
abstract：:Signaling pathways underlying the cognitive deficit of the Alzheimer's disease (AD) are not completely understood. Protein kinase C (PKC), a major neuronal protein plays a critical role in cellular signal transduction and it is known to be subjected to modulation in AD. We showed previously that, chronic infusion of b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03608-9
更新日期：2002-12-13 00:00:00
abstract：:Binding activities specific for each of [3H]prostaglandin (PG) D2, E2 and F2 alpha were detected in the P2 fraction of the human brain homogenates. The bindings were time-dependent, saturable and of high affinity; Kd values were 30 nM for all the PG bindings. Regional distribution of these binding activities was deter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91358-7
更新日期：1985-09-02 00:00:00
