Abstract：
:The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glutamate were collected and analyzed. The results showed a developmental increase in both basal and stimulated release. The increase was not caused by changes in [3H]choline uptake or total [3H]ACh synthesized which did not increase with developmental age. The developmental increase is correlated with the time of formation and maturation of retinal cholinergic synapses in ovo, but is not correlated with the developmental decrease in cholinergic synapses formed by retina neurons with striated muscles in vitro.
journal_name
Brain Resjournal_title
Brain researchauthors
Thompson JMdoi
10.1016/0165-3806(82)90137-7subject
Has Abstractpub_date
1982-07-01 00:00:00pages
259-64issue
3eissn
0006-8993issn
1872-6240journal_volume
256pub_type
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