Abstract：
:To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol in primary neuron cultures challenged by beta-amyloid toxicity. All compounds were found to be neuroprotective in an ER-dependent manner. However, protein kinase C (PKC) inhibition completely blocked the protective effects of 17beta-estradiol and 17alpha-estradiol and significantly attenuated PPT but not DPN neuroprotection. These data indicate that estrogen-mediated neuroprotection likely involves a variety of mechanisms and that protection due to PKC activation is more likely due to ERalpha compared to ERbeta.
journal_name
Brain Resjournal_title
Brain researchauthors
Cordey M,Pike CJdoi
10.1016/j.brainres.2005.03.032subject
Has Abstractpub_date
2005-05-31 00:00:00pages
217-23issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00461-0journal_volume
1045pub_type
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