Abstract:
:The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats have a deficient 2-DG-feeding response, but an essentially normal noradrenergic-feeding response. Specific carbohydrate appetite abnormalities were also demonstrated. It is argued that VP influences 2-DG feeding by mobilizing endogenous energy stores following its acute release from the hypothalamoneurohypophysial system. A new function is thus ascribed for VP and the neural lobe of the pituitary. It is suggested that VP plays a role in stress-induced feeding and in specific aspects of carbohydrate appetite. The potential relevancy of vasopressin perturbations to bulimia nervosa and to the Prader-Willi obesity syndrome is also discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Aravich PF,Sladek CDdoi
10.1016/0006-8993(86)91070-xsubject
Has Abstractpub_date
1986-10-22 00:00:00pages
245-52issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)91070-Xjournal_volume
385pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse N1E-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungaro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90493-6
更新日期:1994-08-22 00:00:00
abstract::The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90800-o
更新日期:1992-03-06 00:00:00
abstract::Routine cell stains disclose abnormal, usually single, nests of ectopic neurons in neocortical layer I of New Zealand Black (NZB) and BXSB autoimmune mice. We have suggested that these anomalies represent only the most visible part of more widespread cortical disorganization. In an attempt to determine the true magnit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90828-y
更新日期:1990-10-08 00:00:00
abstract::Activity produced by direct microelectrophoretic application of glutamate onto 19 convergent neurones in trigeminal nucleus caudalis, was strongly depressed during and after the application of heterotopic noxious conditioning stimuli: noxious heat (52 degrees C) applied to the tail, noxious pinches applied to the tail...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90695-4
更新日期:1984-10-29 00:00:00
abstract::The aim of this study was to determine the effect of different concentrations of normobaric oxygen (NBO) on neurological function and the expression of caspase-3 and -9 in a rat model of acute cerebral ischaemia. Sprague-Dawley rats (n=120) were randomly divided into four groups (n=30 per group), including 3 groups gi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.05.027
更新日期:2015-08-27 00:00:00
abstract::A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91641-6
更新日期:1987-12-29 00:00:00
abstract::The medial septal area has been implicated in the control of the magnocellular neurosecretory cells of the hypothalamus, and in particular, in the regulation of neurons secreting oxytocin. The present study investigated the hypothesis that this medial septal pathway originates in the subfornical organ. Brief electrica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01278-p
更新日期:1995-02-20 00:00:00
abstract::Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90147-1
更新日期:1986-02-01 00:00:00
abstract::Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.10.062
更新日期:2015-01-21 00:00:00
abstract::We previously reported that motion sickness was prevented in rats with amygdala lesion and that provocative motion stimuli increased the number of Fos-positive neurons in the amygdala, suggesting that the amygdala is one of the neural substrates involved in the development of motion sickness. NK-1 receptors in the bra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.11.047
更新日期:2012-01-30 00:00:00
abstract::A mutation in the Vps33a gene causes Hermansky-Pudlak Syndrome (HPS)-like-symptoms in the buff (bf) mouse mutant. The encoded product, Vps33a, is a member of the Sec1 and Class C multi-protein complex that regulates vesicle trafficking to specialized lysosome-related organelles. As Sec1 signaling pathways have been im...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.035
更新日期:2009-04-17 00:00:00
abstract::Toxoplasma gondii can cause parasitic encephalitis, a life-threatening infection that predominately occurs in immunocompromised individuals. T. gondii has the ability to invade the brain, but the mechanisms by which this parasite crosses the blood-brain-barrier (BBB) remain incompletely understood. The present study r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147002
更新日期:2020-11-01 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) has been shown to have therapeutical properties in various psychiatric disorders, especially in alcohol abuse, and to mimic different actions of ethanol at the cellular and system level. Using whole-cell patch-clamp recordings on brain slices of 21- to 25-day-old rats, the present study inv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.10.046
更新日期:2004-01-30 00:00:00
abstract::Growth factor-dependent proliferation of neuronal progenitors is an essential stage in CNS development. Although several of these growth factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the CNS during the time of neuronal progenitor expansion suggest NRG1 growth factors m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.025
更新日期:2006-09-07 00:00:00
abstract::We examined the effect of long-term exposure to radio frequency radiation 147 MHz and its sub-harmonics 73.5 and 36.75 MHz amplitude modulated at 16 and 76 Hz (30-35 days, 3 h per day) on cholinergic systems in developing rat brain. A significant decrease in acetylcholine esterase activity was found in exposed rats as...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91729-c
更新日期:1993-01-22 00:00:00
abstract::This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90419-5
更新日期:1983-09-19 00:00:00
abstract::The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91089-y
更新日期:1990-04-09 00:00:00
abstract::Recent neurocognitive studies of visual word recognition provide information about neuronal networks correlated with processes involved in lexical access and their time course (e.g., [Holcomb, Ph.J., Grainger J. and O'Rourke, T. (2002). An Electrophysiological Study of the Effects of Orthographic Neighborhood Size on ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.078
更新日期:2006-02-16 00:00:00
abstract::The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.11.022
更新日期:2017-02-15 00:00:00
abstract::In order to better understand the neuroleptic-like effects of neurotensin in vivo, the effects of neurotensin in vitro on dopamine D2 and D1 agonist and antagonist binding sites were characterized in membranes from the neostriatum and the subcortical limbic area. Neurotensin increased the KD but not the Bmax value of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90753-i
更新日期:1991-10-04 00:00:00
abstract::The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.015
更新日期:2014-11-24 00:00:00
abstract::The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91091-r
更新日期:1992-09-11 00:00:00
abstract::We showed previously, using in vitro microdialysis, that the activation of the soluble guanylate cyclase (sGC)/cyclic GMP pathway was the underlying mechanism of the extracellular Ca(2+)-dependent effects of exogenous NO on dopamine (DA) secretion from PC12 cells. In this study, the co-infusion of the sGC inhibitor 1H...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.07.040
更新日期:2004-10-15 00:00:00
abstract::The levels of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG) were measured in several regions and in whole brain of rats from 15 days of gestation (DG) to adulthood by means of an isocratic HPLC method. The levels of NAAG in whole brain increased 3-fold between 15 DG and birth, which was 90% of the ad...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90150-0
更新日期:1984-07-01 00:00:00
abstract::The diagonal band of Broca (dbB) is involved in central cardiovascular control. In the present study we compared the effects of microinjections of L-glutamate into the dbB of unanesthetized rats with those observed after the injection of L-glutamate into the same area in urethane-anesthetized rats. The microinjection ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03769-1
更新日期:2003-01-10 00:00:00
abstract::It was previously reported that brain areas containing serotonin (5-hydroxytryptamine, 5-HT) receptors mediate memory consolidation as well as short (STM)- and long-term memory (LTM). Here the effects of systemic and intrahippocampal administration of 5-HT agonists and antagonists on an autoshaping learning task were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.007
更新日期:2007-05-25 00:00:00
abstract::Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90337-1
更新日期:1976-08-06 00:00:00
abstract::Drugs thought to inhibit the actions of protein kinase C (PKC) and cAMP dependent protein kinase (A-kinase) were infused intrathecally into the subarachnoid space of the lumbar region of the spinal cord, and the effects on acoustic startle were measured. Previous work has shown that intrathecal infusion of drugs thoug...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90864-8
更新日期:1990-08-20 00:00:00
abstract::The relationship between changes in regional brain bioamine levels and the expression of intraspecies aggressive behavior was evaluated in two murine models. In one study, normal male mice were maintained either in aggregate (i.e., normal, intraspecies social behavioral controls) or isolated (i.e., developed, non-soci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03963-x
更新日期:2003-02-14 00:00:00
abstract::The role of adrenal hormones in mediating the increase in blood glucose levels following several stressful stimuli (environmental and pharmacological) was studied. The role for brain norepinephrine systems in the initiation of the BG response to these challenges was investigated as well. There is disagreement as to wh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90464-2
更新日期:1989-11-13 00:00:00