Abstract：
:Peripheral nerve injury induces changes in gene expressions of a variety of neuroactive substances in cell somata, which may have roles in the adaptive response to the injury, neuronal survival, growth and regeneration. In this study, we designed a rat model of ischemic peripheral facial paralysis with a selective embolization technique, and observed mRNA expression of calcitonin gene-related peptide (CGRP), c-jun, and growth associated protein (GAP)-43 in facial nerve nuclei using in situ hybridization histochemistry. The rats were demonstrated to have a transient facial paralysis consistently, and thus this method was regarded as a model of minor peripheral nerve injury. The mRNA of CGRP, c-jun and GAP-43 showed a distinct pattern of induction and time course of increase after the ischemic nerve injury. The results suggest that the small injury to the peripheral nerve was able to induce changes in mRNA expression in the cell body of motoneurons. We also investigated the protective effect of superoxide dismutase (SOD), which is a free radical-scavenging enzyme involved in cellular antioxidant defenses. The SOD treatment clearly alleviated the behavioral impairment and decreased the CGRP mRNA expression at 3rd day after injury. These data suggest that a free radical generated by the ischemia may be partially responsible for ischemic nerve damage and the change in gene expression in motoneurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Mohri D,Satomi F,Kondo E,Fukuoka T,Sakagami M,Noguchi Kdoi
10.1016/s0006-8993(00)03319-9subject
Has Abstractpub_date
2001-03-02 00:00:00pages
227-36issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03319-9journal_volume
893pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effect of repetitive stimulation of the locus coeruleus (LC) on the discharge rate of spontaneously active neurons of the visual, rostral and cingulate cortex was investigated in untreated and catecholamine-depleted rats under chloral hydrate anesthesia. In untreated animals, the inhibitory transsynaptic effects p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90251-6
更新日期：1980-03-17 00:00:00
abstract：:The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in the limbic forebrain but not the extrapyramidal basal gangl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90083-7
更新日期：1987-02-17 00:00:00
abstract：:The anatomical distribution of L-[3H]glutamate binding sites was determined in the presence of various glutamate analogues using quantitative autoradiography. The binding of L-[3H]glutamate is accounted for by the presence of 3 distinct binding sites when measured in the absence of Ca2+, Cl- and Na+ ions. The anatomic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90936-9
更新日期：1985-08-12 00:00:00
abstract：:The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90427-3
更新日期：1981-12-28 00:00:00
abstract：:During the early postnatal development of the rat large numbers of pyramidal tract neurons are present in layer V of the occipital cortex, but by the end of the third postnatal week the distribution of pyramidal tract neurons becomes restricted to the more rostral cortical areas. This restriction is brought about by s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90661-4
更新日期：1985-06-17 00:00:00
abstract：:Morphological changes in neocortical somatostatin- and neuropeptide-Y-immunoreactive cells in senile dementia of the Alzheimer type (SDAT) were studied using light-microscopic immunohistochemical methods. The density of somatostatin-immunoreactive cells in the neocortex did not decrease in cases of SDAT compared with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91099-1
更新日期：1986-04-02 00:00:00
abstract：:After-effects of fusimotor action on dynamic sensitivity of spindle primary afferents from soleus resulted from low rate stimulation of both static and dynamic gamma-axons. Sensitivity to small sinusoidal stretches superimposed on triangles was enhanced during triangular lengthening but not during shortening. These af...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90289-x
更新日期：1982-01-28 00:00:00
abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90014-2
更新日期：1994-09-26 00:00:00
abstract：:The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibly through its autoregulatory eff...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01965-x
更新日期：2000-03-17 00:00:00
abstract：:This study investigated the effects of N6-cyclopentyladenosine (CPA), a potent and selective adenosine A1 receptor (A1R) agonist in normal and nerve-injured rats and mechanisms of its action by behavioral tests and electrophysiological technique. The results showed: (1) In normal rats, intraperitoneal administration o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.034
更新日期：2010-11-18 00:00:00
abstract：:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91020-3
更新日期：1980-06-16 00:00:00
abstract：:In albino rats the deep layers of the superior colliculus were stimulated, and climbing fiber responses of Purkinje cells were explored in the medial region of the lobulus simplex. They were identified in a strip (ca. 0.7-1.0 mm wide) in the most medial region of folium b. In the tectorecipient zone of the medial acce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90467-7
更新日期：1987-08-11 00:00:00
abstract：:The nature of the delayed blood-brain barrier (BBB) opening that occurs in rats subjected to forebrain ischemia by the technique of two-vessel (carotid) occlusion plus hypovolemic hypotension (2VO ischemia) was probed by examining the simultaneous, trans-barrier movement of two hydrophilic, normally poorly permeative ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00323-5
更新日期：1997-06-27 00:00:00
abstract：:Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.065
更新日期：2011-01-31 00:00:00
abstract：:Cerebral venous thrombosis (CVT) is a rare form of cerebral stroke that causes a variety of symptoms, ranging from mild headache to severe morbidity or death in the more severe forms. The use of anti-coagulant or thrombolytic agents is the classical treatment for CVT. However, the development of new therapies for the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.029
更新日期：2018-11-15 00:00:00
abstract：:There was a distinct sex-related difference in the anterior pituitary level of substance P-like immunoreactivity (SP-LI) in adult rats; the anterior pituitaries of male rats contained a higher concentration of SP-LI than those of females. Neonatal castration (day 1) resulted in a marked decrease of the SP-LI level in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90863-6
更新日期：1983-08-29 00:00:00
abstract：:Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes, obesity, a sedentary lifestyle, and an atherogenic diet. As such, several traits of Type 2 diabetes (T2DM) could be considered pathogenic factors of aging, contributi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.052
更新日期：2015-09-24 00:00:00
abstract：:Ischemic-reperfusion injury in humans occurs in conditions such as stroke, cardiac arrest, subarachnoid hemorrhage or head trauma. Maximal tissue damage is observed during reperfusion, which is primarily attributed to oxidative injury resulting from production of oxygen free radicals. One of the major consequences of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00009-1
更新日期：1996-04-22 00:00:00
abstract：:The ultrastructure of the dorsal column nucleus (DCN) has been investigated at the level of the obex region in normal and experimental toads. Large 'isolated' neurons (greater than 20 micrometer) and clusters of small neurons (less than 20 micrometer) have been identified in this region. Synaptic profiles have been cl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90905-8
更新日期：1978-03-10 00:00:00
abstract：:The postnatal development of the terminal Schwann cell, an analogue of the lamellar cell in cutaneous sensory receptors, was examined by histochemistry for non-specific cholinesterase and immunohistochemistry for S-100 protein in the periodontal Ruffini endings of the rat incisor. Double immunohistochemistry for S-100...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02463-4
更新日期：2000-03-06 00:00:00
abstract：:In a previous study, we have demonstrated that an ovalbumin-like antigen is present within approximately one-half of all neurons of chicken spinal ganglia. The current study demonstrates this antigen co-localizes absolutely with neural intermediate filament protein (Peripherin) in small to medium-sized neurons of spin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90342-k
更新日期：1993-11-12 00:00:00
abstract：:To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00767-6
更新日期：1996-10-28 00:00:00
abstract：:Microinjection of the neuronal inhibitor muscimol into the midbrain lateral/dorsolateral periaqueductal gray (l/dlPAG) suppresses increases in heart rate (HR) and mean arterial pressure (MAP) evoked by microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) into the dorsomedial hypothalamus (DMH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.080
更新日期：2006-05-30 00:00:00
abstract：:The location and morphological characteristics of gamma-aminobutyric acid (GABA)-immunopositive cells and their processes were studied in rat and mouse first somatosensory (SI) cortex (including 'barrels') in layer IV, and layers above (I-III), and below (V and VI). In coronal sections of SI cortex of both species GAB...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91472-2
更新日期：1988-01-26 00:00:00
abstract：:Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90834-3
更新日期：1975-01-17 00:00:00
abstract：:Previous neuroimaging studies provided evidence that visual mental imagery relies, in part, on the primary visual cortex. We hypothesized that, analogous to the finding that motor imagery increases the excitability of motor cortex, visual imagery should increase visual cortex excitability, as indexed by a decrease in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02478-2
更新日期：2002-05-31 00:00:00
abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor abundantly expressed in the postnatal brain that is involved in the differentiation of cultured astrocytes. Thus far, the cellular identity and anatomical distribution of STAT3-expressing cells in the postnatal brain is poorly known. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.115
更新日期：2006-07-07 00:00:00
abstract：:Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90499-2
更新日期：1984-07-30 00:00:00
abstract：:Humans share the common intuition of a self that has access to an inner 'theater of mind' (Baars, 2003). The problem is how this internal theater is formed. Moving from Cook's view (Cook, 2008), we propose that the 'sentience' present in single excitable cells is integrated into units of neurons and glial cells transi...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.01.003
更新日期：2012-10-02 00:00:00
abstract：:In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91500-e
更新日期：1992-11-27 00:00:00
