Serotonin-dependent cerebral activation: effects of methiothepin and other serotonergic antagonists.

abstract：:It is well known that locus coeruleus (LC) of the rat shows intense mu-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey (Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in oth...

journal_title：Brain research

authors： Chen J,Koyama N,Kaneko T,Mizuno N

更新日期：1997-05-02 00:00:00

abstract：:An inhibitor of tissue plasminogen activator (tPA) was tested for its effects on the rapid kindling induced by a series of afterdischarges (ADs) triggered in hippocampus over a 3-h period. Rats injected with vehicle prior to the session had prolonged ADs in tests carried out 10 days later. This was not the case for an...

journal_title：Brain research

authors： Hoffman KB,Hwee V,Larson J,Lynch G

更新日期：2000-04-07 00:00:00

abstract：:Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...

journal_title：Brain research

authors： Dietrich MO,Mantese CE,Porciuncula LO,Ghisleni G,Vinade L,Souza DO,Portela LV

更新日期：2005-12-14 00:00:00

abstract：:In the present investigation, electron probe X-ray microanalysis was used to characterize the effects of in vitro ouabain (2 mM) or anoxia on elemental composition (e.g. Na, K, Ca) and water content of rat peripheral (tibial) nerve myelinated axons and Schwann cells. Results showed that independent of axon size, both ...

journal_title：Brain research

authors： Lehning EJ,Doshi R,Stys PK,LoPachin RM Jr

更新日期：1995-10-02 00:00:00

abstract：:Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These da...

journal_title：Brain research

authors： Zhang RX,Liu B,Lao L,Qiao JT,Ruda MA

更新日期：2005-03-21 00:00:00

abstract：:Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...

journal_title：Brain research

authors： Simon NW,Moghaddam B

更新日期：2017-01-01 00:00:00

abstract：:Effects of nitric oxide on glutamate (Glu) release in long-term potentiation (LTP) were investigated by superfusion of conventional (P2) and large (P3) synaptosomes prepared from the rat hippocampus. Basal releasing rates of endogenous Glu from P2 and P3 fractions were 103.6 and 85.2 pmol/min/mg protein, respectively....

journal_title：Brain research

authors： Kamisaki Y,Maeda K,Ishimura M,Omura H,Moriwaki Y,Itoh T

更新日期：1994-04-25 00:00:00

abstract：:The spinothalamic projection in an avian species, the pigeon, was studied both with anterograde and retrograde means. Anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP) was used in order to determine the termination of the spinothalamic tract in the thalamus. Application to the l...

journal_title：Brain research

authors： Schneider A,Necker R

更新日期：1989-04-10 00:00:00

abstract：:A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...

journal_title：Brain research

authors： Cannizzaro C,Martire M,Steardo L,Cannizzaro E,Gagliano M,Mineo A,Provenzano G

更新日期：2002-10-25 00:00:00

abstract：:To test the hypothesis that presence of metalloproteases (MMPs), their inhibitors (TIMPs) and their substrate laminin-5 differs between the ischemic core and the surrounding tissue, we examined the impact of middle cerebral artery occlusion/reperfusion (MCA:O/R) on these molecules in different regions of the infarct. ...

journal_title：Brain research

authors： Wagner S,Nagel S,Kluge B,Schwab S,Heiland S,Koziol J,Gardner H,Hacke W

更新日期：2003-09-12 00:00:00

abstract：:To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...

journal_title：Brain research

authors： Appelt DM,Balin BJ

更新日期：1997-01-16 00:00:00

abstract：:Hemicholinium-3 (HCh-3) is a potent and specific inhibitor of the high-affinity choline transport process (HAChT) localized on cholinergic neurons. In this study, the specific binding of [3H]HCh-3 (120 Ci/mmol) was characterized in crude synaptic membranes prepared from rat brain. The binding of [3H]HCh-3 to forebrain...

journal_title：Brain research

authors： Sandberg K,Coyle JT

更新日期：1985-12-02 00:00:00

abstract：:Inoculation of the tail base of rats with Mycobacterium butyricum led to an arthritic swelling and inflammation of the limbs which displayed a hyperalgesia to noxious pressure: these effects peaked at 3 weeks postinoculation. In vitro autoradiography of coronal sections of rat brain was used for a parallel determinati...

journal_title：Brain research

authors： Millan MJ,Morris BJ,Colpaert FC,Herz A

更新日期：1987-07-28 00:00:00

abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...

journal_title：Brain research

authors： Cuello AC,Del Fiacco M,Paxinos G

更新日期：1978-09-08 00:00:00

abstract：:The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...

journal_title：Brain research

authors： Inoue Y,Nakamura R,Mikoshiba K,Tsukada Y

更新日期：1981-08-24 00:00:00

abstract：:Receptor subunit composition is believed to play a major role in the synaptic trafficking of AMPA receptors (AMPARs), and thus in activity-dependent synaptic plasticity. To isolate a physiological role of GluA1-containing AMPARs in area CA3 of the hippocampus, pair recordings were performed in organotypic hippocampal ...

journal_title：Brain research

authors： Selcher JC,Xu W,Hanson JE,Malenka RC,Madison DV

更新日期：2012-01-30 00:00:00

abstract：:Phonological working memory (PWM) tasks consist of a sequence of stimulus-encoding, maintenance and response. Few previous functional magnetic resonance imaging (fMRI) studies of PWM have employed event-related designs that make it possible to analyze the activations associated with each phase of such a task. The expl...

journal_title：Brain research

authors： Strand F,Forssberg H,Klingberg T,Norrelgen F

更新日期：2008-05-30 00:00:00

abstract：:6-[18F]Fluoro-L-DOPA (FDOPA) is an imaging agent used in the study of dopamine terminals in the living brain using positron emission tomography (PET). To better understand the role of tracer metabolism in dynamic FDOPA PET studies, the pharmacokinetics of individual FDOPA metabolites in extracellular space in the stri...

journal_title：Brain research

authors： DeJesus OT,Haaparanta M,Solin O,Nickles RJ

更新日期：2000-09-15 00:00:00

abstract：:To determine the effects of nerve injury on Fos expression, temporal and spatial distributions of Fos-positive neurons in the trigeminal nucleus caudalis were examined after tissue injury for isolation of the infraorbital nerve as controls and transection of this nerve as well as noxious chemical stimulation by formal...

journal_title：Brain research

authors： Terayama R,Nagamatsu N,Ikeda T,Nakamura T,Rahman OI,Sakoda S,Shiba R,Nishimori T

更新日期：1997-09-12 00:00:00

abstract：:In the neonatal kitten, cuneate neurones activated by tactile stimulation of the forelimb foot pads are divisible into 3 functional classes each of which appears to receive its glabrous skin input selectively from a single class of tactile receptors. Their properties suggest that the functionally specific patterns of ...

journal_title：Brain research

authors： Ferrington DG,Rowe MJ

更新日期：1981-06-01 00:00:00

abstract：:Rabbits reared from birth in stroboscopic illumination have no experience of visual motion. In primary visual cortex of these animals there is a large reduction in the number of cells which are direction selective. This result, contrary to previous reports, shows that the rabbit visual system can be modified by early ...

journal_title：Brain research

authors： Pearson HE,Berman N,Murphy EH

更新日期：1981-01-01 00:00:00

abstract：:The distribution of neural elements immunoreactive to several peptides with a possible messenger role was studied in the lamprey spinal cord by using an indirect immunofluorescence method. Different patterns of immunoreactive (IR) fibers were detected by antisera raised against cholecystokinin, metorphamide, bombesin,...

journal_title：Brain research

authors： Buchanan JT,Brodin L,Hökfelt T,Van Dongen PA,Grillner S

更新日期：1987-04-07 00:00:00

abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...

journal_title：Brain research

authors： Cooper B,Werner HB,Flügge G

更新日期：2008-03-04 00:00:00

abstract：:Putative N-type voltage-sensitive calcium channels were localized autoradiographically in thaw-mounted rat brain slices using [125I]omega-conotoxin GVIA as a ligand. Density of the toxin binding sites were highly heterogeneous throughout the brain. The highest density of the binding sites was observed in the glomerula...

journal_title：Brain research

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1988-06-07 00:00:00

abstract：:We have previously demonstrated that NMDA receptor-mediated extracellular adenosine accumulation in neuronal cultures is receptor-mediated and requires calcium influx. Because protein kinase C (PKC) is a calcium-dependent enzyme, we hypothesized that activation of PKC might be involved in NMDA-mediated adenosine accum...

journal_title：Brain research

authors： Lu Y,Rosenberg PA

更新日期：2007-06-25 00:00:00

abstract：:The effects of neonatal dopamine depletion on activity levels and locomotor patterns were tested in rats at 4 months of age. Measurements were taken using an activity pattern monitor. The lesioned group was significantly hypoactive in comparison to the control animals during the initial exposures to the monitor. Exami...

journal_title：Brain research

authors： Moy SS,Breese GR,Eckerman DA

更新日期：1994-05-09 00:00:00

abstract：:A quantitative study of Wallerian degeneration was carried out on teased fibres. The breakdown into ovoids was used as the criterion of degeneration. The fragmentation of fibres begins near the point of nerve interrruption and spreads along the unbranched parts of axons at velocities correlated with fibre diameter and...

journal_title：Brain research

authors： Lubińska L

更新日期：1977-07-08 00:00:00

abstract：:The effects of 24 and 48 h of food deprivation on changes in the activity of dopaminergic (DAergic) neurons and D-amphetamine-induced rotational behavior were studied in male and female Long-Evans rats. Food deprivation selectively altered 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial prefrontal cortex (PFC) bu...

journal_title：Brain research

authors： Carlson JN,Glick SD,Hinds PA,Baird JL

更新日期：1988-06-28 00:00:00

abstract：:Headache medicine is primarily dependent on patients' subjective reports of pain, which are assessed at diagnosis and throughout the duration of treatment. There is a need for an objective, quantitative biological measurement of headache pain severity. In this study, quantitative sensory testing (QST) was conducted vi...

journal_title：Brain research

authors： Nguyen RH,Ford S,Calhoun AH,Holden JK,Gracely RH,Tommerdahl M

更新日期：2013-03-01 00:00:00

abstract：:This study has presented cells, fibers and non-neuronal elements as seen in 3 dimensions using the SEM. Our discussion on possible artifacts which can occur with this method is offered in the hope that others will develop better techniques of dissection and specimen preparation. With the picture of normal tissue in mi...

journal_title：Brain research

authors： Paul LA,Fried I,Scheibel AB

更新日期：1984-12-01 00:00:00