Abstract：
:Headache medicine is primarily dependent on patients' subjective reports of pain, which are assessed at diagnosis and throughout the duration of treatment. There is a need for an objective, quantitative biological measurement of headache pain severity. In this study, quantitative sensory testing (QST) was conducted via multi-site vibrotactile stimulation in patients with migraine. The purpose was to investigate the sensitivity of the method and to determine if the metrics obtained from migraineurs could be differentiated from controls. Metrics reflecting sensory percepts of baseline measures of stimulus amplitude discrimination, temporal order judgment, and duration discrimination were significantly different. Additional measures previously demonstrated to be sensitive to alterations in centrally-mediated information processing features such as adaptation and synchronization were also significantly different from control values. In contrast, reaction times and vibrotactile detection thresholds of migraineurs failed to differentiate them from controls, indicating that the results are not due to peripheral neuropathy or some other primary afferent mechanism. The long-term objective of the study is to develop methods that can improve diagnosis and enable more accurate assessments of treatment efficacy in migraine.
journal_name
Brain Resjournal_title
Brain researchauthors
Nguyen RH,Ford S,Calhoun AH,Holden JK,Gracely RH,Tommerdahl Mdoi
10.1016/j.brainres.2012.12.043subject
Has Abstractpub_date
2013-03-01 00:00:00pages
50-8eissn
0006-8993issn
1872-6240pii
S0006-8993(13)00005-Xjournal_volume
1498pub_type
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