Effects on the growth of damaged ganglion cell axons after peripheral nerve transplantation in adult hamsters.


:After transplantation of autologous sciatic nerve segments into the retina of adult hamsters for 1-2 months, retrograde labelling with horseradish peroxidase demonstrated a population of ganglion cells situated peripheral to the graft. If an additional lesion was placed between the insertion of the graft and the optic disc at the same time as transplantation, in addition to labelled cells situated peripheral to the graft, retrograde labelling with horseradish peroxidase demonstrated a population of labelled neurons located between the graft and the optic disc which was not observed in animals without the additional lesion. Since the axons of this population of cells would have to turn around away from their normal course towards the optic disc and travel for about 1.5 mm in order to grow into the graft, it suggests that the peripheral nerve graft might play an active role in attracting and/or guiding damaged ganglion cell axons to grow into it.


Brain Res


Brain research


So KF,Xiao YM,Diao YC




Has Abstract


1986-07-02 00:00:00














  • Electrophysiological correlates of the efficient detection of emotional facial expressions.

    abstract::Behavioral studies have shown that emotional facial expressions are detected more rapidly and accurately than are neutral expressions. However, the neural mechanism underlying this efficient detection has remained unclear. To investigate this mechanism, we measured event-related potentials (ERPs) during a visual searc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sawada R,Sato W,Uono S,Kochiyama T,Toichi M

    更新日期:2014-04-29 00:00:00

  • Far field effects of seizure like events induced by application of 4-AP in combined entorhinal cortex hippocampal slices.

    abstract::Epileptiform activity induced by 4-AP in hippocampal area CA1 is characterised by short recurrent discharges. These are occasionally superimposed by slow field potential (fp) shifts. Simultaneous recordings of fps and [K(+)](o) in area CA1 and temporal cortex showed a slow fp shift in both regions, but associated rise...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Breustedt J,Gloveli T,Heinemann U

    更新日期:2002-11-22 00:00:00

  • Cardiovascular responses to gustatory and mechanical stimulation of the nasopharynx in rats.

    abstract::The effects of natural (mechanical and gustatory) stimulation of the nasopharynx or electrical stimulation of the pharyngeal branch of the glossopharyngeal (PH-IXth) nerve on the changes in heart rate (HR) and arterial blood pressure (BP) were investigated in paralyzed and anesthetized rats. Afferent responses in the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hanamori T,Ishiko N

    更新日期:1993-08-13 00:00:00

  • Ultrastructural damage and neuritic beading in cold-stressed spinal neurons with comparisons to NMDA and A23187 toxicity.

    abstract::While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Emery DG,Lucas JH

    更新日期:1995-09-18 00:00:00

  • CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbits.

    abstract::We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), an...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nalivaiko E,Blessing WW

    更新日期:2004-08-13 00:00:00

  • Anoxic terminal negative DC-shift in human neocortical slices in vitro.

    abstract::In animal models, the hallmark of a hypoxic condition is a strong negative shift of the DC potential (anoxic terminal negativity, ATN). This DC-shift is interpreted to be primarily due to a breakdown of the membrane potential of neurons. Such massive neuronal depolarizations have not been reported for all human neocor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Köhling R,Schmidinger A,Hülsmann S,Vanhatalo S,Lücke A,Straub H,Speckmann EJ,Tuxhorn I,Wolf P,Lahl R,Pannek H,Oppel F,Greiner C,Moskopp D,Wassmann H

    更新日期:1996-11-25 00:00:00

  • Intracellular recording and staining of cat's lateral geniculate neurons.

    abstract::Intracellular staining with recording micropipettes filled with a Procion yellow solution was attempted on 11 lateral geniculate neurons of chloralose-anesthetized cats for the purpose of correlating electrophysiologically identified cell types with morphologically identified cell types. Five neurons were successfully...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ogawa T,Takimori T,Takahashi Y

    更新日期:1978-01-06 00:00:00

  • The role of altered sodium currents in action potential abnormalities of cultured dorsal root ganglion neurons from trisomy 21 (Down syndrome) human fetuses.

    abstract::Trisomy 21 (Down syndrome) results in abnormalities in electrical membrane properties of cultured human fetal dorsal root ganglion (DRG) neurons. Action potentials have faster rates of depolarization and repolarization, with decreased spike duration, compared to diploid neurons. In order to analyze the faster depolari...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Caviedes P,Ault B,Rapoport SI

    更新日期:1990-03-05 00:00:00

  • The enhanced processing of visual novel events in females: ERP correlates from two modified three-stimulus oddball tasks.

    abstract::The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...

    journal_title:Brain research

    pub_type: 杂志文章,随机对照试验


    authors: Yuan J,Xu S,Li C,Yang J,Li H,Yuan Y,Huang Y

    更新日期:2012-02-09 00:00:00

  • Vasopressin reverses aluminum-induced impairment of synaptic plasticity in the rat dentate gyrus in vivo.

    abstract::Aluminum (Al), an important neurotoxin, contributes to a variety of cognitive dysfunction and mental diseases. Previous studies have demonstrated that Al impairs hippocampal long-term potentiation (LTP) in vitro and in vivo. In the present study, both LTP and LTD (long-term depression) were recorded in the same animal...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wang M,Chen JT,Ruan DY,Xu YZ

    更新日期:2001-04-27 00:00:00

  • Calbindin-D28k content and firing pattern of hippocampal granule cells in amygdala-kindled rats: a perforated patch-clamp study.

    abstract::The dentate gyrus is believed to play an important pathophysiological role during experimentally induced kindling. In this study, we investigated whether an altered content of the calcium binding protein calbindin-D(28k) or an increased intrinsic excitability of hippocampal granule cells contribute to the induction of...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dietrich D,Podlogar M,Ortmanns G,Clusmann H,Kral T

    更新日期:2005-01-25 00:00:00

  • Distribution of monoamines within the central nervous system of the juvenile pulmonate snail, Achatina fulica.

    abstract::The distributions of serotonin and catecholamines were examined within the central ganglia of juvenile Achatina through the histological localization of serotonin-like immunoreactivity and of glyoxylic acid-induced fluorescence. Somata containing these amines were widely distributed throughout all central ganglia exce...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Croll RP

    更新日期:1988-09-13 00:00:00

  • Effect of acetazolamide on rate of CO2 uptake in the perfused rat brain.

    abstract::The accumulation of acid-labile CO2 was measured in the rat brain at early times after exposure to 30% CO2 in oxygen. In particular, the effect on CO2 accumulation of inhibiting brain carbonic anhydrase with acetazolamide was studied. For 57 rats, a rat head perfusion technique was used which permits control and rapid...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Thompson AM,Thompson JL,Robertson RC

    更新日期:1980-09-15 00:00:00

  • Tolerance of neonatal rat brain to acute hyperammonemia.

    abstract::The aim of the present work was to study the effects of hyperammonemia on brain energy metabolism in neonatal rats. Rats were rendered hyperammonemic by ammonium acetate administration. This decreased brain ATP concentrations but enhanced brain ammonia and lactate levels in both adult and neonatal rats. In adult rats,...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: García MV,López-Mediavilla C,Juanes de la Peña MC,Medina JM

    更新日期:2003-05-23 00:00:00

  • Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats.

    abstract::Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other parts of the brain. Cerebral blood flow mapping was performed using [...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wang Z,Guo Y,Mayer EA,Holschneider DP

    更新日期:2019-08-15 00:00:00

  • Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

    abstract::Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD) even after adjustment for age. Though transgenic mouse models of AD develop AD-related amyloid beta (Abeta) and/or tau pathology, gender differences have not been well documented in these models. In this study, we found that fem...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hirata-Fukae C,Li HF,Hoe HS,Gray AJ,Minami SS,Hamada K,Niikura T,Hua F,Tsukagoshi-Nagai H,Horikoshi-Sakuraba Y,Mughal M,Rebeck GW,LaFerla FM,Mattson MP,Iwata N,Saido TC,Klein WL,Duff KE,Aisen PS,Matsuoka Y

    更新日期:2008-06-24 00:00:00

  • 5-Hydroxytryptamine (5-HT) agonists: effects on neocortical slow wave activity after combined muscarinic and serotonergic blockade.

    abstract::In freely-moving rats treated with a combination of reserpine (10 mg/kg, i.p.) and scopolamine (5 mg/kg, i.p.), neocortical low voltage fast activity (LVFA) associated with continuous multiunit activity (MUA) was abolished and replaced by 2-6 Hz large irregular slow activity (LISA) above 1.5 mV associated with a burst...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dringenberg HC,Vanderwolf CH

    更新日期:1996-07-29 00:00:00

  • Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate.

    abstract::The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in cultu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Manev H,Favaron M,Candeo P,Fadda E,Lipartiti M,Milani D

    更新日期:1993-10-08 00:00:00

  • Neuropeptides derived from prosomatostatin that do not contain the somatostatin-14 sequence.

    abstract::Two neuropeptides reacting with antibodies directed against the C-terminal region of somatostatin 28(1-12) were purified to homogeneity from rat brain extracts. Amino acid analysis revealed that the larger peptide (8 kdaltons) consisted of 76 amino acids. Microsequencing established its aminoterminal structure as: Ala...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Benoit R,Böhlen P,Esch F,Ling N

    更新日期:1984-10-08 00:00:00

  • Thyrotropin-releasing hormone (TRH) improves survival in anaphylactic shock: a central effect mediated by the sympatho-adrenomedullary beta-adrenoceptive system.

    abstract::Treatment with thyrotropin-releasing hormone (TRH) significantly improved survival following induction of fatal systemic anaphylaxis in mice. The protective effect was mediated centrally since survival was increased by intracerebroventricular (i.c.v.) administration of TRH at doses which had no effect when given syste...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Amir S,Harel M,Schachar A

    更新日期:1984-04-30 00:00:00

  • Spectral opponency of on-type ganglion cells and the blue preference of Rana pipiens.

    abstract::Spectrally opponent processes of ON-type retinal ganglion cells and the blue preference behavior were identified by parallel physiological and behavioral experiments in Rana pipiens. Spectral opponency of retinal ON-units was measured by recording from optic nerve terminals in the anterior thalamus, while the retina w...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kicliter E,Kay CJ,Chino YM

    更新日期:1981-04-06 00:00:00

  • Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum.

    abstract::This paper describes carbon fibre electrodes that can simultaneously monitor changes in ascorbic acid, dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in vivo in the rat striatum using differential pulse voltammetry. The separation between DOPAC and 5HIAA oxidation is...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Crespi F,Sharp T,Maidment NT,Marsden CA

    更新日期:1984-11-19 00:00:00

  • Regional neuroleptic microinjections indicate a role for nucleus accumbens in lateral hypothalamic self-stimulation reward.

    abstract::Bilateral microinjections of the neuroleptic, cis-flupenthixol, were made into 56 forebrain targets distributed across various dopamine (DA) terminal fields in the forebrain. Drug effects on medial forebrain bundle (MFB) stimulation-produced reward were assessed with a rate-frequency procedure implemented in a runway ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Stellar JR,Corbett D

    更新日期:1989-01-16 00:00:00

  • A distinctive soma size gradient among catecholaminergic neurones of human retinae.

    abstract::We have examined the soma diameters and distribution of catecholaminergic (CA) cells in human retinae, by using an antibody to tyrosine hydroxylase (TH), the rate limiting enzyme in the production of catecholamines. TH-immunoreactivity was detected in two classes of cells (CA1 and CA2 cells). CA1 cells had relatively ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mitrofanis J,Provis JM

    更新日期:1990-09-10 00:00:00

  • The transthyretin gene is expressed in Schwann cells of peripheral nerves.

    abstract::Transthyretin (TTR) is mainly expressed in the liver and choroid plexus of the brain. The majority of familial amyloidotic polyneuropathy cases are caused by a mutant TTR gene. The origin of the TTR deposited in the peripheral nervous system is unknown. We studied the expression of TTR in the peripheral nerves of norm...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Murakami T,Ohsawa Y,Zhenghua L,Yamamura K,Sunada Y

    更新日期:2010-08-12 00:00:00

  • Terminations of primary afferents on lumbar motoneurons in the turtle Pseudemys scripta elegans.

    abstract::The existence of monosynaptic contacts between primary afferents and motoneurons in the lumbar spinal cord of the turtle Pseudemys scripta elegans was demonstrated by intracellular injections of horseradish peroxidase. Three afferent-motoneuron combinations were satisfactorily labeled and revealed 1, 4 and 6 contacts ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ruigrok TJ,Crowe A,ten Donkelaar HJ

    更新日期:1985-07-22 00:00:00

  • Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors.

    abstract::The interaction of glutamatergic and dopamine neurotransmission is thought to have relevance to both the pathophysiology and pharmacotherapy of schizophrenia. For example, subanesthetic doses of the N-methyl-D-aspartate receptor (NMDA-R) antagonist ketamine induce schizophrenia-like behavioral effects in humans and bo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Miyamoto S,Mailman RB,Lieberman JA,Duncan GE

    更新日期:2001-03-16 00:00:00

  • Involvement of human left frontoparietal cortices in neural processes associated with task-switching between two sequences of skilled finger movements.

    abstract::In this study, we demonstrate the involvement of left frontoparietal cortices in neural processes for task-switching between skilled movements. Functional magnetic resonance imaging was conducted while thirty-two right-handed healthy participants performed two sequential finger-movement tasks with their left hands. On...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Uehara S,Mizuguchi N,Hirose S,Yamamoto S,Naito E

    更新日期:2019-11-01 00:00:00

  • Functional recovery of the ventilatory chemoreflexes after partial chronic denervation of the nucleus tractus solitarius.

    abstract::In pentobarbitone-anesthetized cats breathing spontaneously, we studied whether excision of one petrosal ganglion would modify the reflex efficacy of the remaining carotid and aortic chemoafferences in ventilatory control. Resting ventilation was not affected shortly after the ganglionectomy, but decreased sensitiviti...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Eugenin J,Larrain C,Zapata P

    更新日期:1990-07-23 00:00:00

  • Is there a non-synaptic component in the K+-stimulated release of GABA in the developing rat cortex?

    abstract::Postnatal development of the K+-stimulated release of [3H]GABA in rat cortex slices was compared to the density of Gray type 2 synapses (which correlate with GABAergic synapses in rat cortex). The [3H]GABA release system develops earlier than the inhibitory synapses which suggests that, at least in the young cortical ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Balcar VJ,Dammasch I,Wolff JR

    更新日期:1983-11-01 00:00:00