Abstract：
:Sleep is posited to be a fundamental property of groups of highly interconnected neurons and regulated in part by activity-dependent sleep regulatory substances such as tumor necrosis factor alpha (TNFalpha). We show that the unilateral local application of TNFalpha onto the somatosensory cortex of rats induced state- and frequency-dependent EEG asymmetries. In contrast, the unilateral injection of a TNFalpha inhibitor, a TNFalpha soluble receptor, attenuated sleep deprivation-enhanced EEG slow wave power ipsilaterally during non-rapid eye movement sleep (NREMS) but not during REMS or waking. Results are consistent with the notion that sleep begins with state changes occurring within small groups of highly interconnected neurons and is driven in part by the local production of sleep regulating substances.
journal_name
Brain Resjournal_title
Brain researchauthors
Yoshida H,Peterfi Z,García-García F,Kirkpatrick R,Yasuda T,Krueger JMdoi
10.1016/j.brainres.2004.02.055subject
Has Abstractpub_date
2004-05-29 00:00:00pages
129-36issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304003956journal_volume
1009pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Recordings of single unit activity before, during and after a 1-h continuous exposure were made from the mitral cell layer of the olfactory bulbs of awake rabbits. Thirteen complete 1-h exposures were performed using 8 neurons, while a further 6 neurons were lost before the end of the exposure. During the first few mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90951-9
更新日期：1982-10-28 00:00:00
abstract：:The activity of neurons identified as or similar to spinothalamic tract cells was compared in anesthetized, intact monkeys and in unanesthetized, decerebrate or spinalized animals. Background activity and responses to A- and C-fiber volleys were smaller in decerebrate than in the other preparations, suggesting the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90454-2
更新日期：1984-07-30 00:00:00
abstract：:The light and electron microscopic localization of leucine-enkephalin-containing terminals in the facial nucleus of the rat were investigated by means of the peroxidase-antiperoxidase (PAP) immunocytochemical technique. By light microscopy, leucine-enkephalin-like immunoreactive (LEI) terminals were unevenly distribut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90517-6
更新日期：1983-09-05 00:00:00
abstract：:Long-term memory formation for passive-avoidance learning in the day-old chick is known to have two distinct time windows of protein synthesis (F.M. Freeman, S.P.R. Rose, A.B. Scholey, 1995. Two time windows of anisomycin-induced amnesia for passive-avoidance training in the day-old chick. Neurobiol. Learn. Mem. 63, 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02181-8
更新日期：2000-05-12 00:00:00
abstract：:The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91155-2
更新日期：1985-09-16 00:00:00
abstract：:Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT receptors. The role of 5-HT5A receptor in neuropathic pain has not previously studied. The purpose of this study was to investigate: A) the role of 5-HT5A receptors in rats subjected to spinal nerve injury; B) the expression of 5-HT5A ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.043
更新日期：2015-10-05 00:00:00
abstract：:Response conflict can be induced by priming multiple responses competing for control of action in trials. The N2 is one functionally-related cognitive control index for response conflict. And yet the underlying whiter matter neural substrates of inter-individual difference in conflict N2 remain unclear. So the aim of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.008
更新日期：2017-12-01 00:00:00
abstract：:Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90093-b
更新日期：1991-06-28 00:00:00
abstract：:In Long-Evans Cinnamon (LEC) rats of three different ages (7, 13 and 32 weeks old) concentrations of Cu, Zn and Fe were measured in 8 regions of the brain. The LEC groups aged 7 and 13 weeks showed low concentrations of Cu in all regions compared to Long-Evans Agouti (LEA) rats. In 32-week-old LEC rats, however, Cu co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91587-5
更新日期：1992-08-21 00:00:00
abstract：:The 2,3-benzodiazepine derivative GYKI 52466 has been well characterized as a negative modulator of AMPA-type glutamate receptors. The present study re-examined the effects of GYKI 52466 on AMPA receptor-mediated currents in patches excised from pyramidal neurons in the hippocampal CA1 field and found that this drug h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03323-0
更新日期：2001-02-23 00:00:00
abstract：:The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90090-i
更新日期：1991-06-28 00:00:00
abstract：:The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91028-4
更新日期：1983-03-07 00:00:00
abstract：:Pharmacological properties of glycine (Gly)-induced Cl- current (ICl) in the dorsal cochlear nucleus (DCN) neurons acutely dissociated from C57BL/6J mouse were investigated in the whole-cell configuration of the patch-clamp technique. Gly-induced ICl increased in a sigmoidal manner with higher Gly concentrations. Stry...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90794-a
更新日期：1992-03-06 00:00:00
abstract：:The relationship between seizure propensity and the vascular anatomy of the anterior cerebral arteries, or stroke induced by unilateral ligation of the common carotid artery, was investigated utilizing well differentiated colonies of seizure-prone (SP) and non-seizure-prone (NSP) gerbils. Twenty SP and 20 NSP gerbils ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90867-8
更新日期：1982-02-25 00:00:00
abstract：:The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.098
更新日期：2009-12-08 00:00:00
abstract：:The purpose of this study was to identify the CNS cellular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure and non-seizure rat brain. Analysis of P2X7 immunocytochemistry (ICC) revealed small immunoreactive cells with processes showing distinct morphological changes as se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.040
更新日期：2006-05-17 00:00:00
abstract：:1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90934-7
更新日期：1989-05-15 00:00:00
abstract：:Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90139-8
更新日期：1985-04-29 00:00:00
abstract：:The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly redu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91033-4
更新日期：1986-01-22 00:00:00
abstract：:In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the per...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90511-1
更新日期：1986-03-26 00:00:00
abstract：:Soluble amyloid beta protein (A beta)1-40 and highly amyloidogenic A beta 1-42/43 were immunocytochemically labeled in lysosomes of acinar cells and macrophages in the pancreas of transgenic mice systemically expressing a C-terminal fragment of the A beta precursor. A beta 1-42/43 and long A beta species extending the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00695-1
更新日期：1997-08-15 00:00:00
abstract：:Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spon...
journal_title：Brain research
pub_type： 杂志文章,收录出版
doi：10.1016/j.brainres.2006.11.080
更新日期：2007-02-23 00:00:00
abstract：:In sections of rat brain treated for Wisteria floribunda agglutinin (WFA) labelling the occurrence of parvalbumin (PARV)-, calbindin (CALB)- or choline acetyltransferase (ChAT) immunoreactivity was analyzed in the basal forebrain using dual-peroxidase and double-fluorescence methods. Only PARV-immunoreactive (-ir) neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91205-7
更新日期：1993-12-17 00:00:00
abstract：:The synaptic protein alpha-synuclein is found throughout the brain, although its function remains ill-defined. Abnormal accumulations of alpha-synuclein have been recognised to be associated with a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Nevertheless, little is know...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.072
更新日期：2004-04-09 00:00:00
abstract：:The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90653-1
更新日期：1988-09-06 00:00:00
abstract：:Dissimilarity of the electroencephalogram (EEG) between the two hemispheres was characterized by cross-approximate entropy (C-ApEn), an information statistical parameter applicable to nonlinear, aperiodic signals. EEGs were recorded bipolarly with pairs of epidural electrodes in the left and right frontal cortices. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03358-9
更新日期：2002-11-01 00:00:00
abstract：:Antisense oligodeoxynucleotides (ODNs) are used for the selective inhibition of gene expression. Antisense ODNs are promising tools for the investigation of physiological implications of proteins in the central nervous system of rodents in vivo. We have previously demonstrated that a phosphorothioate antisense ODN to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00463-0
更新日期：1997-08-08 00:00:00
abstract：:Immunohistochemical and neuronal tracing methods were used in cats to determine which type of postganglionic sympathetic neuron is innervated by preganglionic neurons which contain corticotrophin releasing factor-like immunoreactivity (CRF-LI). Preganglionic neurons with CRF-LI have their cell bodies at two restricted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90399-t
更新日期：1992-12-25 00:00:00
abstract：:The ability to ponder the future is a hallmark of human imagination. Neuroimaging research so far has focused on episodic prospection, or thinking about hypothetical future personal events. What has received no attention is semantic prospection or contemplating hypothetical future world events. Using functional magnet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.084
更新日期：2008-10-03 00:00:00
abstract：:The effects of subchronic administration of the antidepressant fluoxetine (15 mg/kg i.p., 14 days) on thyroid hormone metabolism were investigated in 11 regions of the CNS and three peripheral tissues in the rat. Fluoxetine significantly enhanced the activity of the 5'II-deiodinase isoenzyme (5'D-II), which catalyzes ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91424-9
更新日期：1994-01-28 00:00:00
