Abstract：
:The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine ([3H]MK 801) binding in well-washed membranes obtained from rat brain. These results show that certain nicotinic agonists can interact with the NMDA receptor and block its function.
journal_name
Brain Resjournal_title
Brain researchauthors
Aizenman E,Tang LH,Reynolds IJdoi
10.1016/0006-8993(91)90958-xsubject
Has Abstractpub_date
1991-06-14 00:00:00pages
355-7issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90958-Xjournal_volume
551pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Abrupt withdrawal from chronic alcohol exposure can produce convulsions that are likely due to ethanol (EtOH) neuroadaptations. While significant efforts have focused on elucidating dependence mechanisms, the alterations contributing to EtOH withdrawal severity are less well characterized. The present studies examined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.043
更新日期：2005-06-07 00:00:00
abstract：:An effective animal model for elucidating the neurobiological basis of human smoking should simulate important aspects of this behavior. Therefore, a 23 h unlimited access nicotine self-administration model was used to compare inbred Lewis rats, which have a propensity to self-administer drugs of abuse, to inbred Fish...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03375-3
更新日期：2002-03-15 00:00:00
abstract：:To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00524-t
更新日期：1995-08-14 00:00:00
abstract：:Recent work in our laboratory has demonstrated that spontaneous or evoked climbing fiber inputs are associated with an increased responsiveness of Purkinje cells to mossy fiber inputs activated by natural peripheral stimuli. These experiments were designed to test the hypothesis that this increased responsiveness occu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91027-8
更新日期：1984-08-20 00:00:00
abstract：:The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91297-e
更新日期：1991-04-05 00:00:00
abstract：:This study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01561-9
更新日期：1999-07-24 00:00:00
abstract：:Photic entrainment of the circadian oscillator located in the hypothalamic suprachiasmatic nucleus (SCN) is considered to be mediated at least partly by release of glutamate from the retinal presynaptic nerve terminals acting via a NMDA receptor. Several NMDA receptor subtypes have been cloned and expressed in model s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91171-n
更新日期：1993-12-31 00:00:00
abstract：:To understand the functional organization of the piriform cortex (PC), the axon collaterals of three pyramidal cells in layer IIb of the anterior PC and one pyramidal cell in layer IIb of the posterior PC were labeled and quantitatively analyzed by intracellular biocytin injection in the guinea pig. Single pyramidal c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.085
更新日期：2004-11-05 00:00:00
abstract：:The cell-mediated inflammatory component of experimental autoimmune encephalomyelitis (EAE) in mice is measured by the radioisotopic technique. Mice are challenged with autologous spinal cord homogenate in Freund's complete adjuvant and at various time intervals after such immunization given [125I]5-iodo-2'-deoxyuridi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90850-3
更新日期：1979-10-05 00:00:00
abstract：:Opioids elicit antinociception in mammals through three distinct types of receptors designated as mu, kappa and delta. However, it is not clear what type of opioid receptor mediates antinociception in non-mammalian vertebrates. Radioligand binding techniques were employed to characterize the site(s) of opioid action i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02967-x
更新日期：2000-11-24 00:00:00
abstract：:Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02768-9
更新日期：2003-07-18 00:00:00
abstract：:A large body of evidence shows that methamphetamine (METH) causes sustained damage to the brain in animal models and human METH users. In chronic users there are indications of cognitive and motor deficits. Striatal neuropeptides are in a position to modulate the neurochemical effects of METH and consequently striatal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.010
更新日期：2013-05-13 00:00:00
abstract：:To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90364-0
更新日期：1984-07-23 00:00:00
abstract：:Based on electrophysiological data showing that repeated cocaine administration produces persistent enhancement of D1 dopamine (DA) receptor-mediated responses in nucleus accumbens (NAc), we investigated whether changes in neurochemical properties of these receptors resulted when rats were injected with cocaine (15 mg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90783-6
更新日期：1992-02-28 00:00:00
abstract：:Progestin-concentrating neurons in the preoptic area and hypothalamus that project to the midbrain in the female rat were identified using the combined steroid hormone autoradiography-retrograde axonal tracing technique. Progesterone target neurons were most abundant in the periventricular preoptic area and the medial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91545-r
更新日期：1990-06-25 00:00:00
abstract：:The present investigations were designed to assess the effect of the serotoninergic system on luteinizing hormone (LH) and LH-releasing hormone (LH-RH) secretion in female rats aged 14 and 30 days. The administration of 5-hydroxytryptophan (5-HTP; 75 mg/kg i.p.) increased hypothalamic serotonin (5-HT) concentrations i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91634-s
更新日期：1990-07-16 00:00:00
abstract：:Electrophysiological studies using rats were performed to examine the influence of locus coeruleus (LC) on nucleus accumbens (Acc) neurons. Spike generation by hippocampal stimulation was inhibited by both LC conditioning stimulation and iontophoretic application of noradrenaline, but spikes elicited by stimulation of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90172-6
更新日期：1985-07-15 00:00:00
abstract：:In the present study, we performed immunohistochemical studies to investigate the changes of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation. In contrast to the controls, a high density of Bcl-2-IR astrocytes were detected all around the gray matter of the spina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03014-6
更新日期：2000-12-29 00:00:00
abstract：:Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90989-8
更新日期：1985-12-09 00:00:00
abstract：:Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because it produces pleasurable enhancement of such sensation. There have been no electrophysiological studies that report the consequences of MDMA on sensory input. The pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.048
更新日期：2009-12-11 00:00:00
abstract：:Using one microelectrode inserted into a Limulus retinular cell, simultaneous recordings were made of the receptor potential evoked by light falling on that retinular cell and of the optic nerve action potentials generated in the eccentric cell coupled to that retinular cell. The postreceptor transfer function for sen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91320-4
更新日期：1985-02-25 00:00:00
abstract：:Noxious heat applied to the footpad evokes the expression of fos protein-like immunoreactivity in the rat spinal cord lumbar dorsal horn. Electrical stimulation in the medullary nucleus raphe magnus (NRM) while not evoking fos-like immunoreactivity itself, reduced significantly the number of neurons (to 50% of control...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91306-2
更新日期：1990-10-22 00:00:00
abstract：:Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90099-u
更新日期：1992-03-20 00:00:00
abstract：:Primary gaze fixation in healthy individuals is frequently interrupted by microsaccades and saccadic intrusions (SI). The neural systems responsible for the control of attention and eye movements are believed to overlap and in line with this, the behaviour of microsaccades appears to be affected by exogenous and endog...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.047
更新日期：2007-04-13 00:00:00
abstract：:The present experiments were designed to evaluate pharmacologically the role of three neuroanatomically related systems--dopamine, glutamate and GABA--in the motor-stimulant response to amphetamine and cocaine. The data indicate that stimulant-induced stereotypy is blocked by antagonists of all three systems and that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01334-e
更新日期：1995-02-06 00:00:00
abstract：:Neurofibrillary tangles (NFTs) are a pathological hallmark of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17). However, the cellular origin and the consequence of the NFT formation are poorly un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.106
更新日期：2004-10-01 00:00:00
abstract：:Myelin deficiency (mld) is an autosomal recessive mutation in mice characterized by a severe myelin deficit in the central nervous system (CNS). The primary defect in mld is a reduction of the synthesis of the myelin basic protein (MBP) and probably lies in a regulatory element of the MBP gene. In young mld heterozygo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90045-3
更新日期：1987-12-01 00:00:00
abstract：:Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.09.009
更新日期：2018-12-15 00:00:00
abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90969-t
更新日期：1993-11-19 00:00:00
abstract：:Noxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. The aim ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.057
更新日期：2011-05-19 00:00:00
