Kainic acid responses and toxicity show pronounced Ca2+ dependence.

Abstract:

:Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.

journal_name

Brain Res

journal_title

Brain research

authors

Hori N,Ffrench-Mullen JM,Carpenter DO

doi

10.1016/0006-8993(85)90989-8

subject

Has Abstract

pub_date

1985-12-09 00:00:00

pages

380-4

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(85)90989-8

journal_volume

358

pub_type

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