Abstract:
:Norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MOPEG) were determined in medio-basal hypothalamus of adult male rats using high-performance liquid chromatography to study nutritional modulation of noradrenergic turnover. Acute starvation, as well as 3 weeks of semistarvation with a low-protein high-carbohydrate or high-protein low-carbohydrate diet decreased NE turnover significantly, as estimated by MOPEG concentration. Low-protein semistarvation resulted in subnormal concentrations of large neutral amino acids (LNAA), high-protein semistarvation in elevated concentrations. Tyrosine/LNAA ratio and calculated tyrosine flow into brain and brain tyrosine levels were reduced in both types of semistarvation. Corticosterone was low in low-protein and high in high-protein diet. These results suggest that tyrosine availability in brain potentially contributes to reduced NE turnover in starvation.
journal_name
Brain Resjournal_title
Brain researchauthors
Schweiger U,Warnhoff M,Pirke KMdoi
10.1016/0006-8993(85)90471-8subject
Has Abstractpub_date
1985-06-03 00:00:00pages
207-12issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90471-8journal_volume
335pub_type
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