当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Longitudinal variation in cell density and mossy fiber reorganization in the dentate gyrus from temporal lobe epileptic patients.

Longitudinal variation in cell density and mossy fiber reorganization in the dentate gyrus from temporal lobe epileptic patients.

Abstract：

:Variation in cell loss and mossy fiber reorganization was examined along the longitudinal axis of the dentate gyrus from temporal lobe epileptic (TLE) patients. Previous evidence has indicated that the anterior hippocampus is prone to seizure activity. We compared granule and hilar cell number in addition to Timm stain density of the molecular layer and hilus in more anterior and more posterior specimens of hippocampus obtained from patients surgically treated for intractable epilepsy by the removal of the anterior half of the hippocampus. Granule cells/mm in the more anterior specimen were less than or equal to those in the more posterior specimen locations in 77% of the patients, while there was no significant difference in hilar neuron density between the two blocks. These results demonstrate a significantly greater pathology in the granule cell layer in more anterior specimens and no difference in pathology for hilar neurons. Molecular layer Timm stain density was significantly greater in the more anterior specimen of 71% of the patients. The molecular layer Timm stain density ratio was inversely related to hilar cell density in more anterior specimens, whereas in more posterior specimens there was no significant relationship with hilar cell density. Our observations show that although differences exist among TLE patients for these neuroanatomic measures, pathology was greater in more anterior specimens. The latter result is consistent with the conclusion that seizure activity may originate in the anterior region of the hippocampus in a majority of patients.

journal_name

Brain Res

journal_title

Brain research

authors

Masukawa LM,O'Connor WM,Lynott J,Burdette LJ,Uruno K,McGonigle P,O'Connor MJ

doi

10.1016/0006-8993(95)00167-o

subject

Has Abstract

pub_date

1995-04-24 00:00:00

pages

65-75

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00167-O

journal_volume

678

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Differentiation in the immunocytochemical features of intrinsic and cortically projecting neurons in the rat claustrum -- combined immunocytochemical and axonal transport study.

    abstract：:Retrograde axonal transport method of the fluorescent tracer FluoroGold (FG) was combined with immunocytochemistry to investigate the occurrence of nitric oxide synthase (NOS), somatostatin (SOM), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in both intrinsic and cortically projecting neurons of the ra...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)02408-8

    authors： Kowiański P,Timmermans JP,Moryś J

    更新日期：2001-06-29 00:00:00

  • A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy.

    abstract：:Neurotrophins play a crucial role in the regulation of survival and the maintenance of specific functions for various populations of neurons. Neurotrophin-4 (NT-4) is most abundant in skeletal muscle, and is thought to promote sciatic nerve sprouting, inhibit agrin-induced acetylcholine receptor (AChR) clustering, evo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)02288-0

    authors： Sakuma K,Watanabe K,Sano M,Uramoto I,Nakano H,Li YJ,Kaneda S,Sorimachi Y,Yoshimoto K,Yasuhara M,Totsuka T

    更新日期：2001-07-13 00:00:00

  • Local sprouting of neurites from cultured PC12D cells in response to a concentration gradient of nerve growth factor.

    abstract：:PC12D cells, a subline of PC12 cells, extend neurites very rapidly in response to NGF, even when RNA synthesis is blocked. Several minutes after the initiation of a concentration gradient of NGF from a micropipette in the vicinity of PC12D cells, clear projections emerged from cells on the side facing the micropipette...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91387-0

    authors： Sano M,Iwanaga M

    更新日期：1994-09-05 00:00:00

  • Ultrastructural evidence for peptidergic innervation of the apical region of frog olfactory epithelium.

    abstract：:Ultrastructural examination of the region near the olfactory epithelial surface of leopard frogs revealed the presence of nerve terminals just proximal to the zonula adherens between adjacent sustentacular cells, and between sustentacular cells and olfactory receptor neurons. Terminal varicosities, located about 20 nm...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90920-7

    authors： Zielinski BS,Getchell ML,Getchell TV

    更新日期：1989-07-17 00:00:00

  • Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus.

    abstract：:The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX , a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas tho...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)91357-x

    authors： Nagai T,Obara S,Kawai N

    更新日期：1984-05-21 00:00:00

  • A slow EPSP in mammalian inferior mesenteric ganglion persists after in vivo capsaicin.

    abstract：:The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were o...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)90227-0

    authors： Peters S,Kreulen DL

    更新日期：1984-06-11 00:00:00

  • Phosphorylation characteristics of the A68 protein in Alzheimer's disease.

    abstract：:As a first step in understanding the function of the 68-kDa Alz-50 antigen (A68) in the pathophysiology of Alzheimer's disease (AD), we have reexamined preliminary observations in our laboratory (Wolozin and Davies, 1986) of a protein kinase activity associated with crude preparations of the protein. This study was un...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90765-4

    authors： Vincent IJ,Davies P

    更新日期：1990-10-29 00:00:00

  • The effect of a conditioning lesion on sudomotor axon regeneration.

    abstract：:The effects of a conditioning lesion on the rate of sudomotor axon regeneration were judged by the recovery of sweat gland (SG) secretion after cholinergic stimulation. Three groups of mice were given a conditioning lesion by crushing the sciatic nerve at mid-thigh 4, 7, and 14 days before a test lesion. A 4th group r...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90547-o

    authors： Navarro X,Kennedy WR

    更新日期：1990-02-19 00:00:00

  • A1 neurons and excitatory amino acid receptors in rat caudal medulla mediate vagal excitation of supraoptic vasopressin cells.

    abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91131-w

    authors： Day TA,Sibbald JR,Smith DW

    更新日期：1992-10-30 00:00:00

  • Morphine-induced suppression of conditioned stimulus intake: effects of stimulus type and insular cortex lesions.

    abstract：:Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived inna...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.07.033

    authors： Lin JY,Roman C,Reilly S

    更新日期：2009-10-06 00:00:00

  • Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress.

    abstract：:Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.02.002

    authors： Duncan GE,Inada K,Farrington JS,Koller BH,Moy SS

    更新日期：2009-04-10 00:00:00

  • Electromyographic and neuromuscular force patterns associated with unexpectedly loaded rapid limb movements.

    abstract：:A series of ballistic, unidirectional arm movements were studied to evaluate the electromyographic (EMG) and neuromuscular force patterns that occur when a limb is unexpectedly perturbed. Multiple training trials were continued with a control load spring attached to the apparatus until a pre-specified criterion for le...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90741-3

    authors： Richardson C,Simmons RW

    更新日期：1985-09-23 00:00:00

  • Alteration of conditioned emotional response and conditioned taste aversion after neonatal ventral hippocampus lesions in rats.

    abstract：:Sprague-Dawley rats were submitted to bilateral ventral hippocampus lesions 7 days after birth according to the Lipska and Weinberger's procedure for modeling schizophrenia. The aim of the present work was to better characterize their learning capacity. A double latent inhibition study was conducted using respectively...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2007.01.093

    authors： Angst MJ,Macedo CE,Guiberteau T,Sandner G

    更新日期：2007-04-27 00:00:00

  • Intracellular calcium changes associated with cholinergic nicotinic receptor activation in cultured myenteric plexus neurones.

    abstract：:Intracellular free calcium concentration ([Ca2+]i) was measured in cultured explants of myenteric plexus neurones by using the fluorescent calcium indicator Indol in combination with patch-clamp techniques. The basal [Ca2+]i was 94 nM and spontaneous oscillations in the internal free calcium concentration were recorde...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)90065-u

    authors： Trouslard J,Mirsky R,Jessen KR,Burnstock G,Brown DA

    更新日期：1993-10-08 00:00:00

  • 5-HT3-like receptors in the rat medial prefrontal cortex: an electrophysiological study.

    abstract：:In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)91316-s

    authors： Ashby CR Jr,Minabe Y,Edwards E,Wang RY

    更新日期：1991-06-07 00:00:00

  • Respiratory and autonomic responses to microinjection of NMDA and AMPA into the commissural subnucleus of the NTS of awake rats.

    abstract：:The changes in mean arterial pressure (MAP) and respiratory frequency (RF) in response to microinjection of NMDA or AMPA into the commissural subnucleus of the NTS (comNTS) at the calamus scriptorius level of awake rats were evaluated. Under tribromoethanol anesthesia, the rats received guide-cannulae in direction of ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2005.09.017

    authors： Almado CE,Machado BH

    更新日期：2005-11-23 00:00:00

  • Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat.

    abstract：:We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91089-b

    authors： Chi SI,Levine JD,Basbaum AI

    更新日期：1993-07-23 00:00:00

  • Localization of angiotensin-converting enzyme, angiotensin II, angiotensin II receptor subtypes, and vasopressin in the mouse hypothalamus.

    abstract：:The hypothalamic angiotensin II (Ang II) system plays an important role in pituitary hormone release. Little is known about this system in the mouse brain. We studied the distribution of angiotensin-converting-enzyme (ACE), Ang II, Ang II receptor subtypes, and vasopressin in the hypothalamus of adult male mice. Autor...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(97)00220-5

    authors： Jöhren O,Imboden H,Häuser W,Maye I,Sanvitto GL,Saavedra JM

    更新日期：1997-05-23 00:00:00

  • Co-localization of estrogen and angiotensin receptors within subfornical organ neurons.

    abstract：:A double-staining immunocytochemical study was done in ovariectomized (OVX) female rats that were either treated with 17beta-estradiol (E(2)) (OVX+E(2)) to produce an approximate circulating level of 30 pg/ml plasma, or not-treated with E(2) (OVX), to investigate the distribution of subfornical organ (SFO) neurons tha...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)01672-8

    authors： Rosas-Arellano MP,Solano-Flores LP,Ciriello J

    更新日期：1999-08-07 00:00:00

  • Cardiovascular effects of acetylcholine microinjection into the ventrolateral and dorsal periaqueductal gray of rats.

    abstract：:In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.11.051

    authors： Deolindo MV,Pelosi GG,Busnardo C,Resstel LB,Corrêa FM

    更新日期：2011-01-31 00:00:00

  • Effects of exposure to an imprinting stimulus on the activity of enzymes involved in acetylcholine metabolism in chick brain.

    abstract：:One-day-old chicks were exposed for 60 min to either an imprinting stimulus or a dark-box. They were killed at 0, 1, 6 or 12 h after the end of this treatment, and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (ChAc) assayed in the forebrain roof, forebrain base and midbrain. The activity...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(75)90271-1

    authors： Haywood J,Hambley J,Rose S

    更新日期：1975-07-11 00:00:00

  • Neonatal ventral hippocampal lesions attenuate the nucleus accumbens dopamine response to stress: an electrochemical study in the adult rat.

    abstract：:Neonatal damage to the ventral hippocampus (VH) can lead, during adulthood, to behaviours that are believed to reflect enhanced mesocorticolimbic dopamine (DA) transmission. In the present study, the effects of neonatal excitotoxic lesions to the VH on spontaneous locomotor activity and stress-elicited increases in ex...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)01477-8

    authors： Brake WG,Sullivan RM,Flores G,Srivastava LK,Gratton A

    更新日期：1999-06-12 00:00:00

  • Relationship between large conductance calcium-activated potassium channel and bursting activity.

    abstract：:To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)01943-0

    authors： Jin W,Sugaya A,Tsuda T,Ohguchi H,Sugaya E

    更新日期：2000-03-31 00:00:00

  • Effects of nerve growth factor on TTX- and capsaicin-sensitivity in adult rat sensory neurons.

    abstract：:We have investigated the effects of nerve growth factor (NGF, 2.5 ng/ml for 1-2 weeks) on enriched adult rat dorsal root ganglion (DRG) neurons maintained in cell culture in defined media. Whole-cell recordings in cells cultured in the absence and presence of NGF revealed no significant difference in resting membrane ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90564-p

    authors： Aguayo LG,White G

    更新日期：1992-01-20 00:00:00

  • Oscillatory brain activity in the human EEG during indirect and direct memory tasks.

    abstract：:Up to today, the neuronal bases of activating and establishing a memory trace are not well understood. Several findings point towards the idea that the activation of an engram is mirrored in induced oscillatory bursts in the gamma frequency range (> 20 Hz; induced gamma band responses; iGBRs). In the present study, we...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.04.069

    authors： Gruber T,Müller MM

    更新日期：2006-06-30 00:00:00

  • Glucose transporters at the blood-nerve barrier are associated with perineurial cells and endoneurial microvessels.

    abstract：:The blood-nerve barrier consists of continuous layers of cells linked by tight junctions and includes the endothelial cells which line the endoneurial capillaries and the perineurial cells which surround fascicles of nerve fibers. A facilitated transport carrier protein allows D-glucose to penetrate the barrier. To de...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)91115-w

    authors： Gerhart DZ,Drewes LR

    更新日期：1990-01-29 00:00:00

  • Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat.

    abstract：:To determine the mechanisms underlying the depolarization induced by anoxia in brainstem neurons, we studied single neurons in brainstem slices using conventional micro-electrodes and freshly dissociated hypoglossal and vagal cells using patch clamp techniques (whole-cell configuration). Since glutamate concentration ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91067-3

    authors： Haddad GG,Jiang C

    更新日期：1993-10-22 00:00:00

  • Heterogeneity of brain melanocortin receptors suggested by differential ligand binding in situ.

    abstract：:The existence of multiple brain melanocortin receptor types has been postulated, based on the complex pharmacology of intracerebrally administered melanocortin (melanocyte-stimulating hormone-related) peptides. In this study, this hypothesis was tested by determining whether different brain melanocortin receptor popul...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91434-6

    authors： Tatro JB,Entwistle ML

    更新日期：1994-01-28 00:00:00

  • Cadmium exposure attenuates the initiation of behavioral sensitization to cocaine.

    abstract：:Employing a paired-watering procedure to control for differential fluid intake confounds, adult male rats were exposed in the home cage to water containing 100 ppm cadmium chloride, or a control solution containing no added cadmium chloride. On Day 61 of exposure to their respective watering regimens, half the animals...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)01060-2

    authors： Nation JR,Livermore CL,Bratton GR

    更新日期：1995-12-08 00:00:00

  • Heterosynaptic stimulation modulates the duration of post-tetanic potentiation at an Aplysia synapse without affecting other aspects of synaptic transmission.

    abstract：:Repetitive stimulation of an axon in the right visceropleural connective to the abdominal ganglion of Aplysia californica produces post-tetanic potentiation (PTP) of a unitary monosynaptic EPSP recorded from cell R15. PTP decays within one half hour following cessation of repatitive stimulation. Stimulation of the lef...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(80)91262-7

    authors： Newlin SA,Schlapfer WT,Barondes SH

    更新日期：1980-01-06 00:00:00