Abstract:
:Neurotrophins play a crucial role in the regulation of survival and the maintenance of specific functions for various populations of neurons. Neurotrophin-4 (NT-4) is most abundant in skeletal muscle, and is thought to promote sciatic nerve sprouting, inhibit agrin-induced acetylcholine receptor (AChR) clustering, evoke postsynaptic potentiation and induce mitochondrial proliferation. Using Western blot analysis, immunoprecipitation and immunohistochemistry, we investigated the distribution of NT-4 in slow- and fast-type muscles. We also tested the adaptive response of this protein in the mechanically overloaded muscle, in the regenerating muscle following bupivacaine injection and in the denervated muscle. Additionally, we investigated whether TrkB phosphorylation in the spinal cord and in the sciatic nerve occurs through the interaction with BDNF or NT-4 when the innervating muscle is damaged. Markedly more NT-4 was expressed in fast-type muscles compared with the slow types. TrkB protein was more frequently observed around the edge of myofibers (neuromuscular junction) of the soleus muscle compared with the gastrocnemius muscle. TrkB tyrosine phosphorylation occurred in the spinal cord but not in the sciatic nerve 24 h after bupivacaine injection of the innervating muscle. At the same time, the amount of TrkB co-precipitating with BDNF was markedly increased in the spinal cord. A rapid activation of TrkB (1-8 h) was also observed in the spinal cord after axotomy,while the amount of TrkB co-precipitating with NT-4 was markedly lower after axotomy. These results indicate that NT-4 is preferentially distributed in fast-type muscles. Furthermore, by interacting with BDNF and NT-4, the TrkB in the spinal cord may be important for the survival of motoneurons and outgrowth of injured peripheral axons following muscle damage.
journal_name
Brain Resjournal_title
Brain researchauthors
Sakuma K,Watanabe K,Sano M,Uramoto I,Nakano H,Li YJ,Kaneda S,Sorimachi Y,Yoshimoto K,Yasuhara M,Totsuka Tdoi
10.1016/s0006-8993(01)02288-0subject
Has Abstractpub_date
2001-07-13 00:00:00pages
1-19issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02288-0journal_volume
907pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Adenosine receptor antagonists, DMPX, PACPX and theophylline, produce contralateral rotations in unilateral 6-hydroxydopamine-lesioned rats. DMPX and theophylline markedly increase rotations produced by bromocriptine (a dopamine D2 receptor agonist) and/or SKF38393A (a dopamine D1 receptor agonist). All of these effec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90925-d
更新日期:1993-06-11 00:00:00
abstract::The effects of acetylcholine (ACh) and physostigmine (PHY) on thoracic ganglion neurons of Locusta migratoria were investigated using whole-cell and cell-attached voltage clamp. ACh activated whole-cell currents with variable amplitudes, time course and ion channel block between cells, suggesting differential expressi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00007-9
更新日期:1998-04-13 00:00:00
abstract::The local cerebral circulatory and metabolic effects of MK-801, a selective non-competitive N-methyl-D-aspartate receptor antagonist have been examined in conscious rats with quantitative autoradiographic techniques using [14C]iodoantipyrine and [14C]2-deoxyglucose as tracers. Local cerebral blood flow (CBF) and local...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90172-8
更新日期:1990-03-19 00:00:00
abstract::Voltage-dependent calcium channels are important for calcium influx and the ensuing intracellular calcium signal in various excitable membranes. The beta subunits of these channels modify calcium currents through pore-forming alpha1 subunits of the high-voltage- activated calcium channels. In the present study, beta3 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.041
更新日期:2007-07-30 00:00:00
abstract::Extracellular microelectrode recordings were made from a total of 868 neurons in the medullas of cats in regions known to contain high densities of respiratory-related neurons (solitary tract complex, nucleus ambiguus/retroambigualis, lateral tegmental field). Both the discharge patterns and the locations of units wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90979-x
更新日期:1984-03-19 00:00:00
abstract::The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90016-2
更新日期:1987-09-01 00:00:00
abstract::The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90360-0
更新日期:1989-04-10 00:00:00
abstract::Electrode-implanted rats pressed a lever to self-stimulate a reward mechanism in their lateral hypothalamus (LH) each time with a brief train of pulses. Interdigitation of a medial hypothalamus (MH) train into the ipsilateral LH train inhibited the reward as indicated by a reduced lever pressing rate. Such interdigita...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90934-4
更新日期:1983-10-31 00:00:00
abstract::Opiates and cannabinoids are among the most widely consumed habit-forming drugs in humans. Several studies have demonstrated the existence of interactions between both kind of drugs in a variety of effects and experimental models. The present study has been focused to determine whether perinatal delta9-tetrahydrocanna...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00766-5
更新日期:1998-10-05 00:00:00
abstract::A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00816-0
更新日期:1997-10-17 00:00:00
abstract::Acute and repeated exposure to cocaine induces long-lasting alterations in neural networks that underlie compulsive drug seeking and taking. Cocaine exposure triggers complex adaptations in the brain that are mediated by dynamic patterns of gene expression that are translated into enduring changes. Recently, epigeneti...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.09.069
更新日期:2015-12-02 00:00:00
abstract::S-allyl cysteine (SAC), a sulfur containing amino acid derived from garlic, has been reported to have antioxidant, anti-cancer, antihepatotoxic and neurotrophic activity. This study was designed to examine the pre-treatment effects of SAC on cognitive deficits and oxidative damage in the hippocampus of intracerebroven...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.072
更新日期:2011-05-10 00:00:00
abstract::Glial-derived monocarboxylate lactate is thought to be an important energy source for neurons during brain activation or in hypoxia-ischemia. Treatment with alpha-cyano-4-hydroxycinnamate (4-CIN), a monocarboxylate transporter inhibitor, has been recently reported to exacerbate delayed neuronal damage in a rat model o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03375-4
更新日期:2003-10-31 00:00:00
abstract::The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.006
更新日期:2004-10-29 00:00:00
abstract::The effects of 24 and 48 h of food deprivation on changes in the activity of dopaminergic (DAergic) neurons and D-amphetamine-induced rotational behavior were studied in male and female Long-Evans rats. Food deprivation selectively altered 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial prefrontal cortex (PFC) bu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90840-2
更新日期:1988-06-28 00:00:00
abstract::This study determined whether macrophage inflammatory protein-1beta (MIP-1beta) plays a role in the hyperthermia caused by prostaglandin E2 (PGE2) given intracerebroventricularly (i.c.v.) in the rat. In these experiments, anti-murine MIP-1beta antibody (anti-MIP-1beta) was micro-injected in the anterior hypothalamic, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01362-5
更新日期:1997-02-14 00:00:00
abstract::Intracellular recordings were made from Renshaw cells in the cat. Recurrent excitatory postsynaptic potentials (EPSPs) were elicited by antidromic stimulation of the ventral roots. These EPSPs had a simple monophasic time course without a spike-like peak reported by previous authors. No hyperpolarization could be dete...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90818-0
更新日期:1981-10-26 00:00:00
abstract::In the present experiment we use a rat model of traumatic brain injury to evaluate the ability of low-pressure hyperbaric oxygen therapy (HBOT) to improve behavioral and neurobiological outcomes. The study employed an adaptation of the focal cortical contusion model. 64 Male Long-Evans rats received unilateral cortica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.105
更新日期:2007-10-12 00:00:00
abstract::The basal ganglia of rhesus and squirrel monkeys were examined using immunohistochemical techniques with antibodies against the neurotensin-related hexapeptides Lys8-Asn9-Neurotensin(8-13) (LANT6) and Neuromedin N. A high percentage of neurons in both segments of globus pallidus and many large neurons of the striatum ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90557-9
更新日期:1987-09-29 00:00:00
abstract::We have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. Cisplatin administration resulted in c-fos-like immunoreactivity (FLI) in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91654-j
更新日期:1991-11-29 00:00:00
abstract::Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean +/- S.D. = 1,234 +/- 543 microm(2)). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related pep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.092
更新日期:2006-04-12 00:00:00
abstract::Basal sleep amounts in adrenalectomized rats (AdX), as compared to intact animals, exhibit a significant increase in slow-wave sleep (SWS), a tendency towards an increase in paradoxical sleep (PS), and circadian rhythms (SWS and PS) flattened in amplitude. An immobilization stress (IS) of 1 h, imposed on AdX rats at t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02313-6
更新日期:2000-01-24 00:00:00
abstract::Nitric oxide (NO) can have opposite effects on peripheral sensory neuron sensitivity depending on the concentration and source of NO, and the experimental setting. The aim of this study was to determine the role of endogenous NO production in the regulation of mechanosensitive Ca(2+) influx of dorsal root ganglion (DR...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02407-6
更新日期:2001-06-08 00:00:00
abstract::Vascular dysfunction is important in the pathogenesis of peripheral complications of diabetes. However, the effects of diabetes on cerebral blood flow and the role of vascular deficits in the pathogenesis of diabetic encephalopathy are still unknown. The present study examined whether experimental diabetes is associat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04211-7
更新日期:2003-03-21 00:00:00
abstract::Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91124-7
更新日期:1984-07-02 00:00:00
abstract::The purpose of this study was to determine the effects of specific proinflammatory cytokines interleukin-6 (Il-6), interleukin-1beta (Il-1beta), interferon-gamma (IFN), and tumor necrosis factor-alpha (TNFalpha), on content and distribution of alpha-synuclein (alpha-synuclein), tau and ubiquitin in human derived cultu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.081
更新日期:2008-06-27 00:00:00
abstract::Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alpha-(2-sulfophenyl)nitrone) to reduce hydroxyl radical formation. Micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02929-2
更新日期:2000-11-17 00:00:00
abstract::Cholecystokinin octapeptide (CCK-8) is colocalized within a majority of dopamine (DA)-containing neurons of the rat midbrain. Exogenous CCK-8 can modulate the electrophysiological activity of DA neurons, at least in part, by direct actions on the somatodendritic region of these cells. If CCK-8 is somatodendritically r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90353-w
更新日期:1991-08-02 00:00:00
abstract::Blockade of gamma-aminobutyric acid (GABA) function in the posterior hypothalamus of rats elicits a pattern of physiological and behavioral arousal consisting of increases in heart rate, respiration and blood pressure as well as intense locomotor stimulation and a selective enhancement of avoidance responding. The pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91173-e
更新日期:1990-03-26 00:00:00
abstract::The binding of the selective alpha 2-adrenoceptor antagonist radioligand [3H]rauwolscine ([3H]RAUW) to homogenates of cat frontal cerebral cortex and cat lumbar spinal cord was investigated. Experiments were performed at 20 degrees C in 50 mM Tris HCl/l mM Na2EDTA buffer (pH 6.9 at 20 degrees C). At this temperature, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91045-0
更新日期:1986-03-12 00:00:00