Local sprouting of neurites from cultured PC12D cells in response to a concentration gradient of nerve growth factor.

abstract：:The afferent connections of the eye of Python reticulatus have been studied with HRP, Nuclear yellow and Granular blue. It appeared that in this snake the eye receives afferent connections from basal telencephalic areas both ipsi- and contralaterally. Following experiments in which Granular blue was injected into one ...

journal_title：Brain research

authors： Hoogland PV,Welker E

更新日期：1981-05-25 00:00:00

abstract：:Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...

journal_title：Brain research

authors： Meyer J,Mischeck U,Veyhl M,Henzel K,Galla HJ

更新日期：1990-04-30 00:00:00

abstract：:MabQ155, a monoclonal antibody against synaptophysin, has been used to conduct a light microscopic survey of synaptogenesis in the suprachiasmatic nucleus of the perinatal rat. Synaptophysin is an integral component of synaptic vesicle membranes which is expressed in growth cones and growth cone filopodia as well as i...

journal_title：Brain research

authors： Laemle LK,Repke KB,Hawkes R,Rice FL

更新日期：1991-03-22 00:00:00

abstract：:Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O(2)) or intermittent hypoxia (IH; 10% and ...

journal_title：Brain research

authors： Li RC,Lee SK,Pouranfar F,Brittian KR,Clair HB,Row BW,Wang Y,Gozal D

更新日期：2006-06-22 00:00:00

abstract：:Cervical spinal cord hemisection leads to a disruption of bulbospinal innervation of phrenic motoneurons resulting in paralysis of the ipsilateral hemidiaphragm. We have previously demonstrated separate therapeutic roles for theophylline, and more recently serotonin (5-HT) as modulators to phrenic nerve motor recovery...

journal_title：Brain research

authors： Basura GJ,Nantwi KD,Goshgarian HG

更新日期：2002-11-22 00:00:00

abstract：:Sheep with guide tubes implanted over the brain lateral ventricles, in order to facilitate episodic sampling of cerebrospinal fluid (CSF), were used to determine the effects of increasing cranial blood osmolality or electroconvulsive shock (ECS) on the permeability of the blood-brain barrier (BBB) to zinc. Zinc acetat...

journal_title：Brain research

authors： Blair-West JR,Denton DA,Gibson AP,McKinley MJ

更新日期：1990-01-15 00:00:00

abstract：:The distribution of cerebellar [3H]flunitrazepam binding sites was studied autoradiographically in Purkinje cell degeneration (pcd/pcd), weaver (wv/wv), staggerer (sg/sg) and reeler (rl/rl) mutant mice. In the normal 78-day-old C57BL/6J mouse cerebellum, the highest concentration of [3H]flunitrazepam binding sites was...

journal_title：Brain research

authors： Rotter A,Frostholm A

更新日期：1988-03-15 00:00:00

abstract：:The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, we...

journal_title：Brain research

authors： Aizenman E,Tang LH,Reynolds IJ

更新日期：1991-06-14 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) plays an essential role in the development of prion diseases. Indirect evidence has suggested that different PrP(C) glycoforms may be expressed in different brain regions and perform distinct functions. However, due to a lack of monoclonal antibodies (Mabs) that are specific ...

journal_title：Brain research

authors： Liu T,Zwingman T,Li R,Pan T,Wong BS,Petersen RB,Gambetti P,Herrup K,Sy MS

更新日期：2001-03-30 00:00:00

abstract：:Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near...

journal_title：Brain research

authors： Rosenbluth J,Tao-Cheng JH,Blakemore WF

更新日期：1985-12-09 00:00:00

abstract：:Glia represents the most numerous group of nervous system cells and CNS development and function depend on glial cells. We developed a purified Muller glia culture to investigate the expression of several neurotransmitter markers on these cells, such as dopaminergic, cholinergic, GABAergic and peptidergic receptors or...

journal_title：Brain research

authors： Kubrusly RC,da Cunha MC,Reis RA,Soares H,Ventura AL,Kurtenbach E,de Mello MC,de Mello FG

更新日期：2005-03-21 00:00:00

abstract：:Tissue accumulation of ornithine (Orn), homocitrulline (Hcit), ammonia and orotic acid (Oro) is the biochemical hallmark of patients affected by hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a disorder clinically characterized by neurological symptoms, whose pathophysiology is practically unknown....

journal_title：Brain research

authors： Viegas CM,Zanatta A,Knebel LA,Schuck PF,Tonin AM,Ferreira Gda C,Amaral AU,Dutra Filho CS,Wannmacher CM,Wajner M

更新日期：2009-09-29 00:00:00

abstract：:Rapid progress in our understanding of macrostructural abnormalities in autism spectrum disorders (ASD) has occurred in recent years. However, the relationship between the integrity of neural tissue and neural function has not been previously investigated. Single-voxel proton magnetic resonance spectroscopy and functi...

journal_title：Brain research

authors： Kleinhans NM,Schweinsburg BC,Cohen DN,Müller RA,Courchesne E

更新日期：2007-08-08 00:00:00

abstract：OBJECTIVES:Neuroprotective benefits of ethanol (EtOH) and normobaric oxygenation (NBO) were previously demonstrated in transient and permanent ischemic stroke. Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be a...

journal_title：Brain research

authors： Geng X,Sy CA,Kwiecien TD,Ji X,Peng C,Rastogi R,Cai L,Du H,Brogan D,Singh S,Rafols JA,Ding Y

更新日期：2015-04-07 00:00:00

abstract：:Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...

journal_title：Brain research

authors： Tyler BM,Cusack B,Douglas CL,Souder T,Richelson E

更新日期：1998-05-11 00:00:00

abstract：:An animal model of self-sustaining status epilepticus (SSSE) induced in rats by brief intermittent perforant path stimulation (PPS) was examined with regard to the effects of two conventional antiepileptic drugs, diazepam and phenytoin. Thirty or sixty minutes PPS induced SSSE characterized by continuous behavioral an...

journal_title：Brain research

authors： Mazarati AM,Baldwin RA,Sankar R,Wasterlain CG

更新日期：1998-12-14 00:00:00

abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...

journal_title：Brain research

authors： Furlong T,Carrive P

更新日期：2007-01-12 00:00:00

abstract：:The D stereoisomer of dihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DHPPA) when infused into the striatum, significantly increased in vivo extracellular dopamine levels. Following D-DOPA administration, the cumulative increase in dopamine levels was 30% of the incr...

journal_title：Brain research

authors： Brannan T,Prikhojan A,Yahr MD

更新日期：1996-04-29 00:00:00

abstract：:Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...

journal_title：Brain research

authors： Dupre KB,Eskow KL,Negron G,Bishop C

更新日期：2007-07-16 00:00:00

abstract：:The effects of 4 anaesthetics, halothane, alpha-chloralose, chloral hydrate and pentobarbitone, on rat striatal extracellular dihydroxyphenylacetic acid (DOPAC) levels were determined using in vivo voltammetry. Stable baseline levels of DOPAC were maintained under halothane/N2O and alpha-chloralose while the extracell...

journal_title：Brain research

authors： Ford AP,Marsden CA

更新日期：1986-07-30 00:00:00

abstract：:We have studied in adult rats bearing a unilateral nigral lesion the effect of nigral grafts into the striatum on behavioral supersensitivity induced by chronic treatment of L-DOPA (100 mg/kg i.p.) plus benserazide (50 mg/kg i.p.). Repeated administration of L-DOPA increases contraversive circling. In rats without gra...

journal_title：Brain research

authors： Gaudin DP,Rioux L,Bédard PJ

更新日期：1990-01-01 00:00:00

abstract：:Aluminum (Al) is among the most abundant elements on earth, it has been associated with the etiology of Alzheimer's disease. In the present study, AlCl(3) was administered with the dose of 10, 50 or 300 mg/kg b.wt/day through diet for 100 days. On day 101, overnight-fasted animals were sacrificed, the whole brains wer...

journal_title：Brain research

authors： Rui D,Yongjian Y

更新日期：2010-04-09 00:00:00

abstract：:Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...

journal_title：Brain research

authors： Dinan TG,Aston-Jones G

更新日期：1985-01-28 00:00:00

abstract：:Patients with subcortical ischemic vascular disease (SIVD) may hold a high risk of cognitive impairment (CI) by affecting the functional connectivity (FC) of resting-state networks (RSNs). Current studies have mainly focused on the patients with CI but have ignored the prodromal stage when people suffered subcortical ...

journal_title：Brain research

authors： Liu X,Chen L,Cheng R,Luo T,Lv F,Fang W,Gong J,Jiang P

更新日期：2019-07-15 00:00:00

abstract：:The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...

journal_title：Brain research

authors： Kasahara Y,Taguchi A,Uno H,Nakano A,Nakagomi T,Hirose H,Stern DM,Matsuyama T

更新日期：2010-06-22 00:00:00

abstract：:Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...

journal_title：Brain research

authors： Falconer EM,Galea LA

更新日期：2003-06-13 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...

journal_title：Brain research

authors： Li S,Chen X,Mao L,Zahid KR,Wen J,Zhang L,Zhang M,Duan J,Duan J,Yin X,Wang Y,Zhao L,Tang X,Wang X,Xu G

更新日期：2018-08-01 00:00:00

abstract：:In epilept WAG/Rij rats, multiple unit activity coinciding with the occurrence of spike-wave discharges was recorded under neurolept anesthesia. Recordings were made in the frontal cortex and in various nuclei of the thalamus, in specific nuclei such as the ventroposterolateral, the ventroposteromedial and the ventrol...

journal_title：Brain research

authors： Inoue M,Duysens J,Vossen JM,Coenen AM

更新日期：1993-05-28 00:00:00

abstract：:Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a well known and popular herbal medicine used worldwide. Among more than 30 ginsenosides, the active ingredients of ginseng, ginsenosides Rb1 and Rg1 are regarded as the main compounds responsible for many pharmaceutical actions of ginseng. In our study, p...

journal_title：Brain research

authors： Radad K,Gille G,Moldzio R,Saito H,Rausch WD

更新日期：2004-09-17 00:00:00

abstract：:Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other region...

journal_title：Brain research

authors： Elliott PJ,Alpert JE,Bannon MJ,Iversen SD

更新日期：1986-01-15 00:00:00