Abstract：
:The D stereoisomer of dihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DHPPA) when infused into the striatum, significantly increased in vivo extracellular dopamine levels. Following D-DOPA administration, the cumulative increase in dopamine levels was 30% of the increase following L-DOPA: following DHPPA it was 11% that of L-DOPA. Rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra demonstrated brisk contralateral turning following each compound. The turning, however, was delayed by 10-20 min and total turning was 40% less following D-DOPA and 57% less following DHPPA than it was following L-DOPA. These data indicate that exogenously administered D-DOPA can be metabolized in vivo within the brain to dopamine and suggest this may occur via a transamination pathway in which DHPPA is an intermediary metabolite. The possible relevance of these findings to the treatment of Parkinson's disease is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Brannan T,Prikhojan A,Yahr MDdoi
10.1016/0006-8993(96)00116-3subject
Has Abstractpub_date
1996-04-29 00:00:00pages
165-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00116-3journal_volume
718pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90164-9
更新日期：1989-08-07 00:00:00
abstract：:Training can induce significant changes in brain functioning and behavioral performance. One consequence of training is changing the pattern of brain activation. Abacus training is of interest because abacus experts gain the ability to handle digits with unusual speed and accuracy. However, the neural correlates of nu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.030
更新日期：2013-11-20 00:00:00
abstract：:Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.077
更新日期：2009-10-19 00:00:00
abstract：:Administration of methamphetamine (15 mg/kg) to adrenalectomized rats significantly decreased hippocampal type I and II corticosteroid receptors as well as type II receptors in the striatum. Type II receptors in the frontal cortex and hypothalamus were unaffected by methamphetamine administration. Pretreatment with MK...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91362-k
更新日期：1990-11-19 00:00:00
abstract：:Butyrate treatment results in the rapid formation of processes on F98 anaplastic glioma cells. The morphological differentiation occurs more rapidly and to a greater extent than that induced by nerve growth factor (NGF). The incorporation of [3H]thymidine is virtually stopped 1 day after treatment of F98 cells with so...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90109-2
更新日期：1982-09-01 00:00:00
abstract：:A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90539-x
更新日期：1982-05-13 00:00:00
abstract：:Immunocytochemical localization of specific neurotransmitters in the brain is becoming increasingly important in studies of maturation. We have used the trilaminar prepyriform cortex (PC) of rats to study the distribution, patterns and relative number of cells, fibers and terminals during postnatal development using a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90208-2
更新日期：1987-08-01 00:00:00
abstract：:During the middle of the subjective day, circadian activity rhythms in Syrian hamsters can be phase advanced by a variety of stimuli including microinjection of neuropeptide Y (NPY) or muscimol into the suprachiasmatic nucleus (SCN). It is not known, however, if these treatments shift activity rhythms by acting direct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00831-7
更新日期：1997-10-24 00:00:00
abstract：:In order to investigate whether a fibrin-fibronectin-containing matrix of a peripheral regeneration chamber could promote the growth of central nervous system neurons, hippocampal and septal slices were co-cultured in the presence of this acellular substrate. In introducing the peripheral matrix into a 2-mm-long tube ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90506-q
更新日期：1991-02-01 00:00:00
abstract：:Fluoro-Gold has been used previously to identify those trigeminal ganglion cells that innervate the central cornea. To examine the effects of Fluoro-Gold treatment on infection and spread of HSV in vivo, we measured the number of plaque forming units recovered from trigeminal ganglia 3 or 5 days after corneal scratch ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90137-c
更新日期：1993-10-15 00:00:00
abstract：:Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Gia and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91111-d
更新日期：1991-05-10 00:00:00
abstract：:Intracerebral injection of kainic acid (KA) in rat brain was previously found to cause altered immunohistochemical recognition of connexin-43 (Cx43) epitopes (epitope masking) with different sequence-specific antibodies against this gap junction protein. We demonstrate here that similar alterations occur when nitrocel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00337-p
更新日期：1995-06-12 00:00:00
abstract：:4-Aminopyridine (4-AP), bicuculline and GABA were applied locally to dorsal horn cells in the lumbar spinal cord in Nembutal-anaesthetized cats and in spinal cats. 4-AP expanded the cutaneous receptive field of 29 of 33 cells tested. Bicuculline and GABA had little or no effect on receptive field size. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90814-5
更新日期：1985-10-07 00:00:00
abstract：:The choroid plexus epithelium constitutes the structural basis of the blood-cerebrospinal fluid barrier. We previously demonstrated that Streptococcus suis (S. suis), a relevant cause of bacterial meningitis in pigs and humans, affects porcine choroid plexus epithelial cell (PCPEC) barrier function and integrity. We n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.041
更新日期：2006-07-19 00:00:00
abstract：:Electroconvulsive stimulation (ECS), the experimental analogue of electroconvulsive therapy (ECT), has been shown to produce both functional and structural effects in the hippocampal formation in infrahuman species. These changes may relate to the antidepressant and cognitive effects of ECT observed in patients treate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.041
更新日期：2005-08-16 00:00:00
abstract：:In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.030
更新日期：2015-11-02 00:00:00
abstract：:The human neostriatum was found to contain large neurons (maximum diameter: 30-40 microns) that stain intensely for acetylcholinesterase (AChE). These neurons are few in number, representing less than 5% of the total striatal neuronal population, and appear uniformly scattered throughout the caudate nucleus and putame...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90663-2
更新日期：1984-01-16 00:00:00
abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02400-8
更新日期：2000-07-07 00:00:00
abstract：:In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carried out pharmacokinetic studies and measured cortical nitric oxide synth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02471-9
更新日期：2000-07-21 00:00:00
abstract：:Regeneration of severed hypothalamic peptidergic neurosecretory axons into the ventral pia-arachnoid was observed in rats at the light microscopic and fine-structural levels. A temporal increase occurred in the number of neurophysin-positive axons regenerating into the leptomeninges for distances up to 3.3 mm by 40 da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91557-0
更新日期：1988-05-31 00:00:00
abstract：:Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90663-8
更新日期：1985-06-17 00:00:00
abstract：:The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02271-6
更新日期：2003-04-18 00:00:00
abstract：:Intoxication with organophosphorus (0P) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91296-3
更新日期：1994-10-17 00:00:00
abstract：:The early electrophysiological phenomena linked to systemic inflammation are largely underexplored. We developed here local field analyses to detect prodromal oscillatory abnormalities. We identified early band-specific patterns in local field potential recorded from freely-moving rats injected intraperitoneally with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.12.036
更新日期：2018-02-15 00:00:00
abstract：:Neuropathic pain remains a major complication of various forms of injury to peripheral nerves in humans. Recently, 2 models of peripheral mononeuropathy in the rat have been described which closely resemble the human condition. Bennett and Xie3 described one model induced by the placement of 4 loose ligatures around t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90570-y
更新日期：1992-01-20 00:00:00
abstract：:Fetal mouse dorsal root ganglion (DRG) neurons were maintained in primary dissociated cell culture for periods of 7 days to 3 months. Intracellular recordings from these cells revealed the presence of spontaneous subthreshold potentials in 101/177 neurons studied. When measured at the resting membrane potential, these...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91450-1
更新日期：1984-02-13 00:00:00
abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.034
更新日期：2012-08-27 00:00:00
abstract：:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91398-4
更新日期：1988-02-16 00:00:00
abstract：:Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91185-1
更新日期：1994-10-24 00:00:00
abstract：:It has been demonstrated previously that kappa opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether kappa agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localizat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02154-0
更新日期：2001-04-13 00:00:00
