Abstract：
:Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other regions of forebrain. In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases in DOPAC levels in forebrain. DA levels were unaffected by SP or DiMe-C7 regardless of the route of administration. These data and previous studies suggest a role for endogenous SP in the modulation of mesocortical and mesolimbic DA neurones.
journal_name
Brain Resjournal_title
Brain researchauthors
Elliott PJ,Alpert JE,Bannon MJ,Iversen SDdoi
10.1016/0006-8993(86)90667-0subject
Has Abstractpub_date
1986-01-15 00:00:00pages
145-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)90667-0journal_volume
363pub_type
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