Nociceptin receptors in the rat spinal cord during morphine tolerance.


:The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [(125)I-Tyr(14)]nociceptin. [(125)I-Tyr(14)]nociceptin appeared to interact with a single class of binding sites (K(D)=0.1 nM) present in the grey matter in all laminae of the spinal cord from cervical to sacral levels. Pre-incubation of sections in the presence of 150 mM NaCl, did not modify the radioligand affinity but significantly augmented the number of accessible binding sites and increased specific binding of [(125)I-Tyr(14)]nociceptin differentially on each laminae. In particular, the superficial layers of the dorsal horn exhibited the highest density of sites after pre-wash. Continuous intrathecal infusion of morphine produced a tolerance accompanied by a significant increase in nociceptin site density in the superficial layers. Thus, nociceptin binding sites may have different properties dependent upon the layer and may be up-regulated during the process of opioid-induced tolerance.


Brain Res


Brain research


Gouardères C,Tafani JA,Meunier JC,Jhamandas K,Zajac JM




Has Abstract


1999-08-14 00:00:00














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    pub_type: 杂志文章


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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yoneda T,Oishi K,Fujikura S,Ishida A

    更新日期:1986-04-30 00:00:00

  • Response dynamics of entorhinal cortex in awake, anesthetized, and bulbotomized rats.

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    authors: Zisapel N,Miskin R,Laudon M,Soreq H

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  • LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain.

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    pub_type: 杂志文章


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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pooters T,Van der Jeugd A,Callaerts-Vegh Z,D'Hooge R

    更新日期:2015-09-24 00:00:00