Nociceptin receptors in the rat spinal cord during morphine tolerance.

Abstract:

:The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [(125)I-Tyr(14)]nociceptin. [(125)I-Tyr(14)]nociceptin appeared to interact with a single class of binding sites (K(D)=0.1 nM) present in the grey matter in all laminae of the spinal cord from cervical to sacral levels. Pre-incubation of sections in the presence of 150 mM NaCl, did not modify the radioligand affinity but significantly augmented the number of accessible binding sites and increased specific binding of [(125)I-Tyr(14)]nociceptin differentially on each laminae. In particular, the superficial layers of the dorsal horn exhibited the highest density of sites after pre-wash. Continuous intrathecal infusion of morphine produced a tolerance accompanied by a significant increase in nociceptin site density in the superficial layers. Thus, nociceptin binding sites may have different properties dependent upon the layer and may be up-regulated during the process of opioid-induced tolerance.

journal_name

Brain Res

journal_title

Brain research

authors

Gouardères C,Tafani JA,Meunier JC,Jhamandas K,Zajac JM

doi

10.1016/s0006-8993(99)01713-8

subject

Has Abstract

pub_date

1999-08-14 00:00:00

pages

85-94

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01713-8

journal_volume

838

pub_type

杂志文章
  • Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway.

    abstract::Ginseng is one of most extensively used traditional oriental medicines worldwide with beneficial efficacy on cognitive function disorders. Pharmacological researches on its active ingredient--ginsenoside Rg1 revealed that it can improve learning and memory potentially via modulating neurotransmission in the central ne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.03.096

    authors: Liu ZJ,Zhao M,Zhang Y,Xue JF,Chen NH

    更新日期:2010-05-28 00:00:00

  • Recruitment threshold force and its changing type of motor units during voluntary contraction at various speeds in man.

    abstract::The motor unit discharges in human hand muscles were recorded during voluntary isometric contraction. Bipolar wire electrodes were inserted in the right adductor pollicis muscle (AP) and first dorsal interosseous muscle (FDI) for the recordings. Motor unit activities from these muscles were investigated when subjects ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91461-7

    authors: Yoneda T,Oishi K,Fujikura S,Ishida A

    更新日期:1986-04-30 00:00:00

  • Response dynamics of entorhinal cortex in awake, anesthetized, and bulbotomized rats.

    abstract::The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02687-7

    authors: Ahrens KF,Freeman WJ

    更新日期:2001-08-24 00:00:00

  • Morphologic features of embryonic neocortex grafts in adult rats following frontal cortical ablation.

    abstract::Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91177-2

    authors: Mufson EJ,Labbe R,Stein DG

    更新日期:1987-01-13 00:00:00

  • Effects of protein undernutrition on the dentate gyrus in rats of three age groups.

    abstract::The effect of an 8% casein and a control 25% casein diet on the granule cells in the dorsal blade of the dentate gyrus of the rat hippocampal formation was studied at 30, 90 and 220 days of age. Female rats were fed either an 8% or 25% casein diet 5 weeks prior to conception and the litters were maintained on these re...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91769-d

    authors: Cintra L,Díaz-Cintra S,Galván A,Kemper T,Morgane PJ

    更新日期:1990-11-05 00:00:00

  • Anterograde tracing of retinohypothalamic afferents with Fluoro-Gold.

    abstract::The anterograde neuronal tracing properties of Fluoro-Gold (FG) were characterized in this study by its ability to label the retinohypothalamic tract (RHT) upon pressure injection of the substance into the vitrous body of the eye in the Djungarian hamster, Phodopus sungorus. Tracing was compared to the anterograde neu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01151-1

    authors: Reuss S,Decker K

    更新日期:1997-01-16 00:00:00

  • Cocaine inhibits hippocampal long-term potentiation.

    abstract::Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. The experiments reported here demonstrate that cocaine blocks the induction of LTP at the excitatory synapses in the CA1 region of the hippocampus, but does not appear to do so by blocking NMDA receptors or channels. O...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91466-6

    authors: Smith DA,Browning M,Dunwiddie TV

    更新日期:1993-04-16 00:00:00

  • Topographic coding of odorant quality is maintained at different concentrations in the salamander olfactory epithelium.

    abstract::In a recent study in the tiger salamander, Ambystoma tigrinum, were demonstrated topographic patterns of responsivity across the olfactory epithelium which were characteristic for each odorant. The present study was initiated to investigate whether these patterns remain constant when odorant concentration is varied. O...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90562-6

    authors: Mackay-Sim A,Shaman P

    更新日期:1984-04-16 00:00:00

  • Malondialdehyde binding of rat cerebral proteins is reduced in experimental hypothyroidism.

    abstract::To determine the effect of thyroid hormones (TH) on cerebral tissue malondialdehyde (MDA) content and accumulation of MDA-bound proteins, hyperthyroid rats and hypothyroid rats were compared to euthyroid controls. Hyperthyroidism was induced by daily injection of l-3,5, 3'-triiodothyronine (15 ug (100 g)-1) intraperit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01368-2

    authors: Chehade J,Kim J,Pinnas JL,Mooradian AD

    更新日期:1999-05-22 00:00:00

  • Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain.

    abstract::Perinatal asphyxia to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term born infants with hypoxic-ischemic encephalopathy, saving one in seven to eight infants from developing severe neurological deficits. Therefore, addi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.05.040

    authors: Strasser K,Lueckemann L,Kluever V,Thavaneetharajah S,Hoeber D,Bendix I,Fandrey J,Bertsche A,Felderhoff-Mueser U

    更新日期:2016-09-01 00:00:00

  • Characterization and partial purification of a 5,700 dalton form of substance P-like immunoreactivity from the rat hypothalamus.

    abstract::Analysis of rat hypothalamic extracts by gel filtration and HPLC revealed the presence of a form of substance P-like immunoreactivity with a molecular weight of approximately 5,700 (6k-SP). 6k-SP is probably an N-terminally extended form of substance P; the peptide may be an intermediate in SP biosynthesis, or may fun...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90310-x

    authors: Harmar AJ,Armstrong A,Lee CM,Emson PC

    更新日期:1984-12-10 00:00:00

  • The nigrostriatal dopamine system: role in the development of hypertension in spontaneously hypertensive rats.

    abstract::The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91739-6

    authors: Linthorst AC,van Giersbergen PL,Gras M,Versteeg DH,de Jong W

    更新日期:1994-03-14 00:00:00

  • Intra-amygdalar okadaic acid enhances conditioned taste aversion learning and CREB phosphorylation in rats.

    abstract::Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.06.029

    authors: Oberbeck DL,McCormack S,Houpt TA

    更新日期:2010-08-12 00:00:00

  • Effects of two volatile anesthetics (sevoflurane and halothane) on the hypothalamic noradrenaline release in rat brain.

    abstract::There are marked increases in noradrenaline (NA) release during emergence from general anesthesia induced with volatile anesthestics. These changes in NA in the posterior hypothalamus of the rat were assessed by intracranial microdialysis. Sevoflurane and halothane in equipotent concentrations were used to obtain the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01080-7

    authors: Chave S,Kushikata T,Ohkawa H,Ishiara H,Grimaud D,Matsuki A

    更新日期:1996-01-15 00:00:00

  • A test of the spine resistance hypothesis for LTP expression.

    abstract::Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines woul...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90454-4

    authors: Larson J,Lynch G

    更新日期:1991-01-11 00:00:00

  • The nociceptin/orphanin FQ-like opioid peptide in nervous periesophageal ganglia of land snail Helix aspersa.

    abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix as...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.007

    authors: León-Olea M,Miller-Pérez C,Sánchez-Islas E,Mendoza-Sotelo J,Garduño-Gutiérrez R,de Gortari P,Amaya MI

    更新日期:2013-04-10 00:00:00

  • Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.

    abstract::Tissue accumulation of ornithine (Orn), homocitrulline (Hcit), ammonia and orotic acid (Oro) is the biochemical hallmark of patients affected by hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a disorder clinically characterized by neurological symptoms, whose pathophysiology is practically unknown....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.07.021

    authors: Viegas CM,Zanatta A,Knebel LA,Schuck PF,Tonin AM,Ferreira Gda C,Amaral AU,Dutra Filho CS,Wannmacher CM,Wajner M

    更新日期:2009-09-29 00:00:00

  • An MEG study of the spatiotemporal dynamics of bilingual verb generation.

    abstract::Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.05.054

    authors: Pang EW,MacDonald MJ

    更新日期:2012-07-27 00:00:00

  • Auditory evoked M100 reflects onset acoustics of speech sounds.

    abstract::Magnetoencephalography (MEG) was used to investigate the response to speech sounds that differ in onset dynamics, parameterized as words that have initial stop consonants (e.g., /b/, /t/) or do not (e.g., /m/, /f/). Latency and amplitude of the M100 auditory evoked neuromagnetic field, recorded over right and left aud...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-8993(98)01058-0

    authors: Gage N,Poeppel D,Roberts TP,Hickok G

    更新日期:1998-12-14 00:00:00

  • Morphine tolerance and dependence in the nucleus paragigantocellularis: single unit recording study in vivo.

    abstract::In this study, a single unit activity was recorded in the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla of anesthetized, morphine-dependent rats. The spontaneous activity of PGi neurons was significantly decreased by administration of morphine (10 mg/kg; i.p.) in sham-operated, cont...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01029-4

    authors: Haghparast A,Semnanian S,Fathollahi Y

    更新日期:1998-12-14 00:00:00

  • Regional levels of brain phospholipase Cgamma in Alzheimer's disease.

    abstract::The levels of PLCgamma, a phospholipase C (PLC) isozyme, were higher in the cytosol fraction than in the membrane fraction in several control brain regions. The levels of PLCgamma were significantly elevated in the membrane, but not in the cytosolic fraction of the hippocampus of AD subjects. In the superior and middl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00935-4

    authors: Zhang D,Dhillon H,Prasad MR,Markesbery WR

    更新日期:1998-11-16 00:00:00

  • P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain.

    abstract::The purpose of this study was to identify the CNS cellular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure and non-seizure rat brain. Analysis of P2X7 immunocytochemistry (ICC) revealed small immunoreactive cells with processes showing distinct morphological changes as se...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.03.040

    authors: Rappold PM,Lynd-Balta E,Joseph SA

    更新日期:2006-05-17 00:00:00

  • Plasminogen activator is enriched in the synaptosomal plasma membranes.

    abstract::The intracellular localization of the serine protease plasminogen activator was analyzed in homogenates of bovine brain cortex using differential fractionation procedures. The distribution of the enzyme was clearly different from that of cytosol and mitochondrial markers, and was similar to that of plasma membrane pro...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)91154-4

    authors: Zisapel N,Miskin R,Laudon M,Soreq H

    更新日期:1982-09-23 00:00:00

  • LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain.

    abstract::A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90415-8

    authors: Yamamoto T,Ochalski A,Hertzberg EL,Nagy JI

    更新日期:1990-02-05 00:00:00

  • Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats.

    abstract::Contradictory results have been reported with regard to the effects of various models of hepatic encephalopathy on the blood-brain barrier (BBB) permeability, which may be due partly to the use of brain concentrations of BBB markers without attention to their peripheral pharmacokinetics. The purpose of the current stu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.07.040

    authors: Shaik IH,Miah MK,Bickel U,Mehvar R

    更新日期:2013-09-19 00:00:00

  • Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats.

    abstract::We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats. This finding indicates that enhanced function of the PPI-coupled excitatory amino acid (EAA...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90370-o

    authors: Akiyama K,Daigen A,Yamada N,Itoh T,Kohira I,Ujike H,Otsuki S

    更新日期:1992-01-08 00:00:00

  • Evolution of Bergmann glia in developing human fetal cerebellum: a Golgi, electron microscopic and immunofluorescent study.

    abstract::Astrogliogenesis in the human fetal cerebellum was examined in 46 cerebella obtained from hysterotomy specimens ranging between 9 and 20 weeks of ovulation age. By correlating the results obtained by rapid Golgi and Golgi-Cox methods, the indirect immunofluorescence technique for glial fibrillary acidic protein, and e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90280-2

    authors: Choi BH,Lapham LW

    更新日期:1980-05-26 00:00:00

  • Immunoreactive avian pancreatic polypeptide in the chicken retina: overall distribution.

    abstract::The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90022-2

    authors: Katayama Y,Kiyama H,Arai Y,Tohyama M

    更新日期:1984-09-17 00:00:00

  • Body weight and regulatory deficits following unilateral nigrostriatal lesions.

    abstract::Unilateral nigrostriatal lesions were performed in rats by punctate injection of 6-hydroxydopamine. Lesioned animals exhibited anorexia and weight loss for 7-11 days after surgery. These animals then displayed normal rate of weight gain. However, there was a chronic depression of body weight in the lesioned animals re...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90195-0

    authors: Baez LA,Ahlskog JE,Randall PK

    更新日期:1977-09-02 00:00:00

  • Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory.

    abstract::Spatial learning and memory in rodents represent close equivalents of human episodic declarative memory, which is especially sensitive to cerebral aging, neurodegeneration, and various neuropsychiatric disorders. Many tests and protocols are available for use in laboratory rodents, but Morris water maze and radial-arm...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.01.015

    authors: Pooters T,Van der Jeugd A,Callaerts-Vegh Z,D'Hooge R

    更新日期:2015-09-24 00:00:00