Abstract：
:The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [(125)I-Tyr(14)]nociceptin. [(125)I-Tyr(14)]nociceptin appeared to interact with a single class of binding sites (K(D)=0.1 nM) present in the grey matter in all laminae of the spinal cord from cervical to sacral levels. Pre-incubation of sections in the presence of 150 mM NaCl, did not modify the radioligand affinity but significantly augmented the number of accessible binding sites and increased specific binding of [(125)I-Tyr(14)]nociceptin differentially on each laminae. In particular, the superficial layers of the dorsal horn exhibited the highest density of sites after pre-wash. Continuous intrathecal infusion of morphine produced a tolerance accompanied by a significant increase in nociceptin site density in the superficial layers. Thus, nociceptin binding sites may have different properties dependent upon the layer and may be up-regulated during the process of opioid-induced tolerance.
journal_name
Brain Resjournal_title
Brain researchauthors
Gouardères C,Tafani JA,Meunier JC,Jhamandas K,Zajac JMdoi
10.1016/s0006-8993(99)01713-8subject
Has Abstractpub_date
1999-08-14 00:00:00pages
85-94issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01713-8journal_volume
838pub_type
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