Abstract:
:The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [(125)I-Tyr(14)]nociceptin. [(125)I-Tyr(14)]nociceptin appeared to interact with a single class of binding sites (K(D)=0.1 nM) present in the grey matter in all laminae of the spinal cord from cervical to sacral levels. Pre-incubation of sections in the presence of 150 mM NaCl, did not modify the radioligand affinity but significantly augmented the number of accessible binding sites and increased specific binding of [(125)I-Tyr(14)]nociceptin differentially on each laminae. In particular, the superficial layers of the dorsal horn exhibited the highest density of sites after pre-wash. Continuous intrathecal infusion of morphine produced a tolerance accompanied by a significant increase in nociceptin site density in the superficial layers. Thus, nociceptin binding sites may have different properties dependent upon the layer and may be up-regulated during the process of opioid-induced tolerance.
journal_name
Brain Resjournal_title
Brain researchauthors
Gouardères C,Tafani JA,Meunier JC,Jhamandas K,Zajac JMdoi
10.1016/s0006-8993(99)01713-8subject
Has Abstractpub_date
1999-08-14 00:00:00pages
85-94issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01713-8journal_volume
838pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The ability of diphenylhydantoin (DPH) to protect against hypoxia-induced neuronal damage was examined using electrophysiological recordings of extracellular evoked potentials from CA1 pyramidal neurons of rat hippocampal slices in vitro. In normal medium, a 15-min hypoxic insult (95% N2/5% CO2) produced rapid and com...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91501-q
更新日期:1991-04-19 00:00:00
abstract::A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transport...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90607-d
更新日期:1990-05-07 00:00:00
abstract::The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91256-0
更新日期:1989-01-09 00:00:00
abstract::There have been few reports concerning facilitation and depression in sympathetic ganglia9,17,40. In the present investigation, pairs of excitatory postsynaptic potentials (EPSPs) were recorded intracellularly from bullfrog paravertebral sympathetic ganglia for an analysis of the site and mechanism responsible for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90840-4
更新日期:1976-12-10 00:00:00
abstract::L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihyp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90985-5
更新日期:1984-03-19 00:00:00
abstract::alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91215-e
更新日期:1993-04-30 00:00:00
abstract::The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.044
更新日期:2007-07-09 00:00:00
abstract::The origin of neuronal perikarya which project to the external zone of the median eminence (the tuberoinfundibular neuronal system) was determined in the rat after injection or diffusion of wheat germ agglutinin (WGA) into the median eminence. The retrogradely transported lectin was detected in neurons using an immuno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90334-1
更新日期:1982-08-05 00:00:00
abstract::The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve growth factor (NGF), is thought to be unable to cross the blood-brain barrier in postnatal mammals. In this stu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91775-n
更新日期:1993-05-14 00:00:00
abstract::Ongoing electrical activity was recorded from the axons of neurosecretory cells from the brain of 5th instar Rhodnius prolixus throughout the moulting cycle. Dramatic changes in both the frequency and pattern of electrical activity occur at specific times during the cycle, enabling the timing of release of neurohormon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90314-5
更新日期:1980-06-02 00:00:00
abstract::The brain contains neurons which alter their firing rates when ambient glucose concentrations change. An ATP-sensitive K+ (Katp) channel on these neurons closes and increases cell firing when ATP is produced by intracellular glucose metabolism. Binding of the antidiabetic sulfonylurea drugs to a site linked to this ch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00835-9
更新日期:1996-11-11 00:00:00
abstract::The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.11.022
更新日期:2017-02-15 00:00:00
abstract::Microinjection of bicuculline (Bic) into the unilateral putamen (Put) of the cat resulted in periodic occurrence of contralateral movement of the head (dystonia). Corresponding to this dystonic movement, repetitive spikes of the field potential occurring in the Put of the injected side and strong inhibition of the ext...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00190-2
更新日期:1995-04-24 00:00:00
abstract::Post-hypoxic myoclonus is a movement disorder characterized by brief, sudden involuntary muscle jerks. Although the mechanism underlying this disorder remains unclear, earlier pharmacological studies indicated that aberrant activity of specific neuronal circuitry in the central nervous system causes this disorder. In ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.08.027
更新日期:2005-10-19 00:00:00
abstract::The mechanism of action of norepinephrine (NE)-induced potentiation of the population spike in the dentate gyrus of hippocampal slices was examined and compared with NE effects in field CA1. NE-induced potentiation was confined to the dentate gyrus, where slices perfused for 30 min with concentrations of NE as low as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91299-5
更新日期:1985-12-30 00:00:00
abstract::Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02715-3
更新日期:2000-09-29 00:00:00
abstract::The excitability of the axonal terminals of medial septal neurons projecting to the dentate gyrus has been studied in the anesthetized rat under various experimental conditions: spontaneous or drug-induced variations in neuronal soma discharge rate, conditioning stimulation of afferent pathways (perforant path, commis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90966-8
更新日期:1987-08-18 00:00:00
abstract::Ciliary ganglion neurons from chick embryo were grown in cell culture following enzymatic and mechanical dissociation. The culture conditions necessary for long-term (greater than 21 days) survival of the isolated neurons were investigated. Neurons could be cultured with and without non-neural cells by adjusting the c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90127-4
更新日期:1980-02-03 00:00:00
abstract::In adult rodents, neuroblasts originating from the subventricular zone migrate tangentially through the rostral migratory stream (RMS) toward the olfactory bulb where they differentiate into interneurons. Neuroblasts in the RMS migrate in chains for a long distance along specifically arranged blood vessels which promo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.08.010
更新日期:2018-11-01 00:00:00
abstract::Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90089-5
更新日期:1981-04-27 00:00:00
abstract::We examined the distribution of choline acetyltransferase (ChAT) mRNA in the brain of six autopsied individuals by in situ hybridization with 35S-labeled human ChAT riboprobes. Neurons containing hybridization signal for ChAT mRNA were observed in the nucleus of the diagonal band of Broca, the basal nucleus of Meynert...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00677-5
更新日期:1998-09-21 00:00:00
abstract::The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of rats after unilateral section of the sciatic nerve or after dorsal rhizotomy. Sciatic nerve section produced a 75--80% d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90167-7
更新日期:1979-05-25 00:00:00
abstract::1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90934-7
更新日期:1989-05-15 00:00:00
abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.025
更新日期:2009-01-16 00:00:00
abstract::Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.001
更新日期:2012-06-06 00:00:00
abstract::Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.042
更新日期:2012-04-23 00:00:00
abstract::Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03291-7
更新日期:2002-01-25 00:00:00
abstract::Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.06.034
更新日期:2012-08-27 00:00:00
abstract::Co-activation of group I metabotropic glutamate (mGlu) receptors and adenosine receptors resulted in an augmented cyclic AMP response in primary cultures of rat striatal neurones. L-glutamate and the selective group I agonist, (S)-dihydroxyphenylglycine (S-DHPG) evoked concentration-dependent potentiations of cyclic A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00094-8
更新日期:1998-04-27 00:00:00
abstract::Single unit extracellular recordings were obtained from cat lumbar spinal cord dorsal horn neurons activated by cutaneous inputs. The effect of electrical conditioning stimuli applied to the red nucleus (RN) was predominantly that of inhibition although in some cases excitation was seen. All the neurons that projected...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91413-6
更新日期:1984-10-08 00:00:00