Abstract：
:A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transported to the neurons of origin of those boutons. Silver enhancement is used to render the ZnSe visible in sections prepared for the light or electron microscope. No evidence of retrograde labeling is apparent in neurons that do not contain zinc in their boutons. Thus, the method provides a chemically specific technique for retrograde tracing of zinc-containing pathways in the CNS.
journal_name
Brain Resjournal_title
Brain researchauthors
Howell GA,Frederickson CJdoi
10.1016/0006-8993(90)90607-dsubject
Has Abstractpub_date
1990-05-07 00:00:00pages
277-86issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(90)90607-Djournal_volume
515pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:After glucocorticoid stimulation, glucocorticoid receptors (GRs) are translocated to the nucleus to modulate transcription of glucocorticoid target genes. The subcellular distribution and trafficking of GR in cultured cells has been studied quite intensively using several techniques. However, the intracellular localiz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.052
更新日期：2010-05-17 00:00:00
abstract：:Previous evidence suggests that preterm newborns with intrauterine growth restriction (IUGR) have specific neurostructural and neurodevelopmental anomalies, but it is unknown whether these effects persist in early childhood. We studied a sample of 18 preterm IUGR, 15 preterm AGA - born between 26 and 34 weeks of gesta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.032
更新日期：2011-03-25 00:00:00
abstract：:The interposed nuclei (IN) of the intermediate cerebellum are critical components of the circuits that control associative learning of eyeblinks and other defensive reflexes in mammals. The IN, which represent the sole output of the intermediate cerebellum, receive massive GABAergic input from Purkinje cells of the ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.053
更新日期：2009-10-06 00:00:00
abstract：:The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90682-3
更新日期：1989-04-17 00:00:00
abstract：:Previous work has suggested that the rewarding effect of hippocampal stimulation develops only as a consequence of neuroplastic change resulting from repeated stimulation experience: naive rats will not initiate self-stimulation for several days, but a prior program of hippocampal kindling greatly facilitates acquisit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91706-m
更新日期：1990-06-18 00:00:00
abstract：:We previously showed that local striatal injections of malonate produce age-dependent excitotoxic lesions. In the present study volumetric analysis confirmed that malonate produces age-dependent striatal lesions. Pretreatment with the non-competitive and competitive NMDA receptor antagonists, MK-801 and LY274614, and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91412-5
更新日期：1994-05-30 00:00:00
abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90585-y
更新日期：1990-05-07 00:00:00
abstract：:Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00743-3
更新日期：1996-10-28 00:00:00
abstract：BACKGROUND:Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the world. There are a lot of drugs that are in experimental stage for treatment of stroke. Among them are calcium channel blockers (CCBs) that have, in animal models, different effectiveness in healing of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.038
更新日期：2007-10-24 00:00:00
abstract：:The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.101
更新日期：2010-06-22 00:00:00
abstract：:Glutamate (2.5 mg) was administered after the blood-brain barrier had been opened by a unilateral intracarotid infusion of 5 mg protamine sulfate in rats. Whereas the brain specific gravity, measured 24 h later, did not differ between the injected and non-injected side after protamine alone, glutamate significantly re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90781-4
更新日期：1992-02-28 00:00:00
abstract：:Cortical sensory neurons synchronize their activity at multiple frequency bands after an external stimulation. In the somatosensory cortical areas, previous reports describe more discrete and somatotopically specific neural synchronization at the gamma band. Therefore, an efficient gamma synchronization of the neurons...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03171-8
更新日期：2003-10-03 00:00:00
abstract：:A number of studies describe strain-related differences in the motor behavior of rats. Inbred albino F344 rats are found to be impaired in procedural spatial learning, skilled reaching, and over ground locomotion in relation to pigmented out bred Long Evans (LE) rats. These deficits could be related to the functional ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.019
更新日期：2004-12-10 00:00:00
abstract：:Ventilated, chloralose anesthetized cats were subjected to 3.2 atmosphere fluid percussion injury and compared with sham operated controls. In both groups, global cerebral blood flow (CBF), cerebral metabolic rate of oxygen utilization (CMRO2), cerebral metabolic rate of glucose utilization (CMRG1), and 31P magnetic r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91205-s
更新日期：1992-07-10 00:00:00
abstract：:The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02175-2
更新日期：2000-05-02 00:00:00
abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03099-2
更新日期：2001-11-30 00:00:00
abstract：:The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of rats after unilateral section of the sciatic nerve or after dorsal rhizotomy. Sciatic nerve section produced a 75--80% d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90167-7
更新日期：1979-05-25 00:00:00
abstract：:The object of this study was to quantify and compare the degree of control monkeys may assert over firing patterns of normal and epileptic neurons. Thirty-seven epileptic and 70 normal neurons were studied in detail. The operant task was for the monkey to generate specified consecutive interspike intervals (ISI). The ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90884-3
更新日期：1978-08-04 00:00:00
abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90016-2
更新日期：1987-09-01 00:00:00
abstract：:Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.035
更新日期：2004-12-17 00:00:00
abstract：:In the present study, the effects of intra-central amygdala (CeA) injection of dopamine D1 receptor agonist and antagonist on morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Our data showed that subcutaneous (s.c.) injection of morphine sulphate (0.5-10 mg/kg) significantly i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04201-4
更新日期：2003-03-07 00:00:00
abstract：:Ontogenic development of the dopaminergic system in rat brain was investigated. This was accomplished by monitoring changes in postsynaptic dopamine receptor formation and presynaptic dopamine content in the midbrain tegmentum, frontal cortex and corpus striatum from the 18th day of gestation through adulthood. The do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90186-1
更新日期：1988-06-01 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) immunoreactivity in rat tissue was assayed using a new reversed-phase, ion-pair, high-pressure liquid chromatography (HPLC) method for separating TRH from its analogs. Virtually all of the TRH immunoreactivity in hypothalamus, brain stem, preoptic area, septum, striatum, frontal cor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91036-7
更新日期：1980-11-17 00:00:00
abstract：:Carnosine is a compound of naturally-occurring dipeptide that synthesized by the carnosine synthetase from beta-alanine and l-histidine. Recent reports claim that carnosine plays an important role in the control of epilepsy but its involvement in anticonvulsant functions remains unknown. In this study, we investigated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.019
更新日期：2008-11-06 00:00:00
abstract：:Neural activity was recorded from 218 sites in the striatum (caudate-putamen and nucleus accumbens) of rats trained on a lever-release version of the conditioned avoidance response (CAR) task, in which an auditory signal elicits a short-latency, forelimb withdrawal. > 80% of these recording sites showed task-related a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90194-r
更新日期：1993-07-09 00:00:00
abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00023-j
更新日期：1995-03-13 00:00:00
abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.056
更新日期：2015-01-30 00:00:00
abstract：:In the preceding series of articles, the history of vertebrate motoneuron and motor unit neurobiological studies has been discussed. In this article, we select a few examples of recent advances in neuroscience and discuss their application or potential application to the study of motoneurons and the control of movemen...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2011.06.008
更新日期：2011-08-29 00:00:00
abstract：:Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.040
更新日期：2015-11-02 00:00:00
abstract：:While adult mice receiving picrotoxin (PTX) alone responded with clonic and tonic-clonic seizures, this response was greatly suppressed for mice simultaneously injected with 2,3-butanedione monoxime (BDM). For example, 60% and 10% of the mice convulsed when injected (i.p.) with 3.0 mg/kg PTX alone or PTX plus 205 mg/k...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00175-p
更新日期：1995-04-24 00:00:00
