Abstract：
:Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP caused an immediate hyperglycaemia which was sustained till the end of the infusion. The rise in plasma glucose levels was accompanied by an increase in endogenous glucose production (EGP), as well as increases in plasma glucagon and insulin concentrations. Furthermore, no differences in plasma corticosterone levels were noted between control and GRP treated rats. These results demonstrate that central GRP increases plasma glucose levels, probably by stimulating pancreatic glucagon release and concomitantly or subsequently endogenous glucose production.
journal_name
Brain Resjournal_title
Brain researchauthors
Jha PK,Foppen E,Challet E,Kalsbeek Adoi
10.1016/j.brainres.2015.08.040subject
Has Abstractpub_date
2015-11-02 00:00:00pages
135-41eissn
0006-8993issn
1872-6240pii
S0006-8993(15)00691-5journal_volume
1625pub_type
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