IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways.


:IL-10 reduces pro-inflammatory responses after ischemic stroke primarily by acting on glia and endothelium, but relatively little is known about the direct effects of IL-10 on cortical neurons, which are often damaged in stroke. We found by PCR and immunohistochemistry that cortical neurons express IL-10 receptor. Treatment of primary cortical neurons in culture with IL-10 increased neuronal survival after exposure to oxygen-glucose deprivation (OGD) or glutamate toxicity. IL-10 also induced phosphorylation of AKT in cortical neurons. Pretreatment with the specific PI-3K inhibitor, wortmannin, attenuated IL-10 mediated neuroprotection against OGD and glutamate. In addition, IL-10 induced STAT-3 phosphorylation. Pre-treatment with a functional blocking antibody to the IL-10 receptor reduced both Stat-3 and AKT phosphorylation and blocked IL-10 mediated protection of cortical neurons. These data suggest that IL-10 provides neuroprotection by acting via IL-10 receptor and PI3K/AKT and STAT-3 signal transduction pathways.


Brain Res


Brain research


Sharma S,Yang B,Xi X,Grotta JC,Aronowski J,Savitz SI




Has Abstract


2011-02-10 00:00:00












  • Increased excitability and reduced intracortical inhibition in the ipsilateral primary motor cortex during a fine-motor manipulation task.

    abstract::The effects of a sensorimotor task on ipsilateral primary motor cortex (ipsi-M1) excitability mediated via the transcallosal pathway, including the changes in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), were examined in ten right-handed subjects. Transcranial magnetic stimulati...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morishita T,Ninomiya M,Uehara K,Funase K

    更新日期:2011-01-31 00:00:00

  • Extracellular K+ accumulation during penicillin-induced epileptogenesis in the CA3 region of immature rat hippocampus.

    abstract::Ion-selective microelectrode techniques were used to study extracellular K+ changes associated with penicillin-induced epileptogenesis in the CA3 region of hippocampal slices. Recordings were made in slices taken from rats 9-16 days of age, which have a pronounced capacity to undergo prolonged synchronized afterdischa...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Swann JW,Smith KL,Brady RJ

    更新日期:1986-12-01 00:00:00

  • Synaptic transmission and paired-pulse behaviour of CA1 pyramidal cells in hippocampal slices from a hibernator at low temperature: importance of ionic environment.

    abstract::To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Igelmund P,Heinemann U

    更新日期:1995-08-14 00:00:00

  • Chronic haloperidol inactivates brain noradrenergic neurons.

    abstract::Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dinan TG,Aston-Jones G

    更新日期:1985-01-28 00:00:00

  • Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation.

    abstract::Thermoregulation is a complex intercommunicative function requiring coordination between core body temperature (CBT), the central nervous system, and peripheral vasculature. In menopausal women, dysregulation of thermoregulatory mechanisms leads to hot flushes and night sweats. A previous study in ovariectomized (OVX)...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pawlyk AC,Cosmi S,Alfinito PD,Maswood N,Deecher DC

    更新日期:2006-12-06 00:00:00

  • Retinal projection to the dorsal raphe nucleus in the Chilean degus (Octodon degus).

    abstract::A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fite KV,Janusonis S

    更新日期:2001-03-23 00:00:00

  • Depletion of C1 neurons attenuates the salt-induced hypertension in unanesthetized rats.

    abstract::High salt intake is able to evoke neuroendocrine and autonomic responses that include vasopressin release and sympathoexcitation resulting in increasing in the arterial blood pressure (BP). The C1 neurons are a specific population of catecholaminergic neurons located in the RVLM region and they control BP under homeos...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ribeiro N,Martins Sá RW,Antunes VR

    更新日期:2020-12-01 00:00:00

  • Properties of single potassium channels in cultured primary astrocytes.

    abstract::The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jalonen T,Holopainen I

    更新日期:1989-04-10 00:00:00

  • NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

    abstract::NMDA receptor (NMDAR) antagonists such as ketamine, can reproduce many of the symptoms of schizophrenia. A reliable indicator of NMDAR channel blocker action in vivo is the augmentation of neuronal oscillation power. Since the coordinated and rhythmic activation of neuronal assemblies (oscillations) is necessary for p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mao Z,He S,Mesnard C,Synowicki P,Zhang Y,Chung L,Wiesman AI,Wilson TW,Monaghan DT

    更新日期:2020-01-15 00:00:00

  • Neuroprotective effect of bicyclol in rat ischemic stroke: down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression.

    abstract:BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang J,Fu B,Zhang X,Chen L,Zhang L,Zhao X,Bai X,Zhu C,Cui L,Wang L

    更新日期:2013-08-28 00:00:00

  • Glutathione metabolism in primary astrocyte cultures: flow cytometric evidence of heterogeneous distribution of GSH content.

    abstract::The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Devesa A,O'Connor JE,Garciá C,Puertes IR,Viña JR

    更新日期:1993-08-06 00:00:00

  • Factors affecting paired-pulse facilitation in hippocampal CA1 neurons in vitro.

    abstract::Factors underlying paired-pulse facilitation (PPF) were studied by intracellular and field recordings of CA1 neurons in the hippocampal slice in vitro, following stimulation of the Schaffer collaterals apical dendritic afferents. Similar magnitudes of PPF were found using the slopes or peaks of the excitatory postsyna...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leung LS,Fu XW

    更新日期:1994-07-04 00:00:00

  • Effect of acetazolamide on rate of CO2 uptake in the perfused rat brain.

    abstract::The accumulation of acid-labile CO2 was measured in the rat brain at early times after exposure to 30% CO2 in oxygen. In particular, the effect on CO2 accumulation of inhibiting brain carbonic anhydrase with acetazolamide was studied. For 57 rats, a rat head perfusion technique was used which permits control and rapid...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Thompson AM,Thompson JL,Robertson RC

    更新日期:1980-09-15 00:00:00

  • The commissural interconnections of the inferior colliculus in the albino mouse.

    abstract::In the inferior colliculus of the mouse, 4 cell types project across the collicular commissure: small to medium sized spiny cells, small to medium sized spineless cells, medium sized sparsely spinous neurons and large cells. The axons of large cells give rise to a great number of ipsi- and contralateral collaterals te...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: González Hernández TH,Meyer G,Ferres-Torres R

    更新日期:1986-03-19 00:00:00

  • GABAergic-serotonergic interactions in regulating lordosis.

    abstract::The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Luine V,Cowell J,Frankfurt M

    更新日期:1991-08-09 00:00:00

  • Substance P: depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons.

    abstract::The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of rats after unilateral section of the sciatic nerve or after dorsal rhizotomy. Sciatic nerve section produced a 75--80% d...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jessell T,Tsunoo A,Kanazawa I,Otsuka M

    更新日期:1979-05-25 00:00:00

  • Toluene inhibits synaptic transmission without causing gross morphological disturbances.

    abstract::The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ikeuchi Y,Hirai H

    更新日期:1994-11-21 00:00:00

  • The neural stem cell secretome and its role in brain repair.

    abstract::Compelling evidence from experimental animal disease models and early-phase clinical trials identifies the transplantation of neural progenitor/stem cells (NSCs) as a viable path towards the development of clinically applicable exogenous stem cell therapies. Building from current advances in the field of NSC biology a...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Willis CM,Nicaise AM,Peruzzotti-Jametti L,Pluchino S

    更新日期:2020-02-15 00:00:00

  • The projections of noradrenergic neurons in the A5 catecholamine cell group to the spinal cord in the rat: anatomical evidence that A5 neurons modulate nociception.

    abstract::Brainstem noradrenergic neurons located in the A5, A6, and A7 catecholamine cell groups provide the entire noradrenergic innervation of the spinal cord. We have previously demonstrated that noradrenergic neurons in the A6 and A7 cell groups innervate the ventral and dorsal horns, respectively. Since the specific spina...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Clark FM,Proudfit HK

    更新日期:1993-07-09 00:00:00

  • Central modulation of gastric pressure by substance P: a comparison with glutamate and acetylcholine.

    abstract::We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As prev...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Spencer SE,Talman WT

    更新日期:1986-10-22 00:00:00

  • A study of the kinetic behaviour of glucose based on simultaneous estimates of influx and phosphorylation in brain regions of rats in different physiological states.

    abstract::Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cremer JE,Ray DE,Sarna GS,Cunningham VJ

    更新日期:1981-09-28 00:00:00

  • Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats.

    abstract::Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nagahara AH,Gill TM,Nicolle M,Gallagher M

    更新日期:1996-01-22 00:00:00

  • In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.

    abstract::The central type benzodiazepine receptor (BDZr), an allosteric modulatory site of the GABAA receptor-anion channel, has been shown in vitro to respond to drugs with positive efficacy (agonists), zero efficacy (competitive antagonists) and drugs with negative efficacy (inverse agonists). However, this general concept o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brouillet E,Chavoix C,Bottlaender M,Khalili-Varasteh M,Hantraye P,Fournier D,Dodd RH,Mazière M

    更新日期:1991-08-23 00:00:00

  • The ability of various chemicals to elicit olfactory beta-waves in the pyriform cortex of meadow voles (Microtus pennsylvanicus) and laboratory rats (Rattus norvegicus).

    abstract::Previous research has shown that, in freely moving laboratory rats, the odors of benzyl alcohol, camphor, carvacrol, isopentenyl methyl sulfide, 2-propylthietane, salicylaldehyde, trimethylthiazoline, and xylene (plus other compounds) elicit high amplitude bursts of roughly 20-Hz waves (beta-waves) in the olfactory bu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vanderwolf CH,Zibrowski EM,Wakarchuk D

    更新日期:2002-01-11 00:00:00

  • Evaluating the amygdala network induced by neurofeedback training for emotion regulation using hierarchical clustering.

    abstract:BACKGROUND:Previous studies have shown that regulating the target region by real-time fMRI-based neurofeedback training can influence the activation of other regions and the functional connectivity between them. However, it is not clear whether the training effect of neurofeedback, especially in emotion regulation, is ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Liu N,Yao L,Zhao X

    更新日期:2020-08-01 00:00:00

  • Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study.

    abstract::Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Radja F,Descarries L,Dewar KM,Reader TA

    更新日期:1993-03-26 00:00:00

  • Glucocorticoid modification of spinal dopamine receptor activation by apomorphine.

    abstract::The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hall ED,Tyler CV Jr

    更新日期:1983-05-16 00:00:00

  • Tonic regulation of the activity of noradrenergic neurons in the locus coeruleus of the conscious rat studied by dual-probe microdialysis.

    abstract::In the present study, receptor specific compounds were infused via a microdialysis probe in the vicinity of the right locus coeruleus (LC). During the infusion of these compounds, the extracellular content of noradrenaline was recorded in the ipsilateral medial prefrontal cortex (mPFC) with a second microdialysis prob...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kawahara Y,Kawahara H,Westerink BH

    更新日期:1999-03-27 00:00:00

  • Differential postnatal development of mu and delta opiate receptors.

    abstract::We found a differential postnatal development of mu and delta opiate receptors. Mu receptors labelled with low concentrations of [3H]naloxone appeared to develop earlier than did delta receptors labelled with [3H]D-Ala2-D-Leu5-enkephalin (0.5 nM). Competition binding studies also revealed a delayed appearance of delta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wohltmann M,Roth BL,Coscia CJ

    更新日期:1982-04-01 00:00:00

  • Unilateral kainic acid lesions reveal dominance of right archistriatum in avian fear behavior.

    abstract::Unilateral injections of 1 microgram of kainic acid in the archistriatum of 5-day-old domestic chicks reduced fear, as expressed by distress calls (peeps), significantly more than did identical injections in the same structure on the left side. This result adds affective behavior to the growing list of functions that ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Phillips RE,Youngren OM

    更新日期:1986-07-09 00:00:00