A solution hybridization assay for the quantitation of prodynorphin mRNA.

abstract：:Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...

journal_title：Brain research

authors： Bregman BS,Goldberger ME

更新日期：1983-08-01 00:00:00

abstract：:Medium conditioned by NG108-15 neuroblastoma x glioma hybrid cells contains a factor which increases the number of acetylcholine receptor (AChR) aggregates on cultured myotubes. Protease digestion indicates that the AChR aggregation factor is a protein, and the molecular weight is from 150,000 to 250,000 daltons as es...

journal_title：Brain research

authors： Bauer HC,Daniels MP,Pudimat PA,Jacques L,Sugiyama H,Christian CN

更新日期：1981-03-30 00:00:00

abstract：:The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...

journal_title：Brain research

authors： Linthorst AC,van Giersbergen PL,Gras M,Versteeg DH,de Jong W

更新日期：1994-03-14 00:00:00

abstract：:Using one microelectrode inserted into a Limulus retinular cell, simultaneous recordings were made of the receptor potential evoked by light falling on that retinular cell and of the optic nerve action potentials generated in the eccentric cell coupled to that retinular cell. The postreceptor transfer function for sen...

journal_title：Brain research

authors： Wang LT,Wasserman GS

更新日期：1985-02-25 00:00:00

abstract：:Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are see...

journal_title：Brain research

authors： Brooks BA,Fuchs AF,Finocchio D

更新日期：1986-09-24 00:00:00

abstract：:The intracellular free Ca2+ concentration ([Ca2+]i) of the bullfrog sympathetic ganglion cell was measured with fura-2 fluorescence under various conditions, and compared with changes in membrane potential recorded with an intracellular electrode. The [Ca2+]i was 109 nM on average under the resting condition and incre...

journal_title：Brain research

authors： Nohmi M,Kuba K,Ogura A,Kudo Y

更新日期：1988-01-12 00:00:00

abstract：:It has been previously established that the housing condition influences the appearance of the dendritic tree in young animals. The purpose of this investigation was to determine the extent of the influence that the housing condition exerts on morphometric studies involving old animals. Specifically, we found superfic...

journal_title：Brain research

authors： Connor JR,Beban SE,Melone JH,Yuen A,Diamond MC

更新日期：1982-11-11 00:00:00

abstract：:This study aimed to identify sites and mechanisms of long-term plasticity following lower limb muscle training. Two groups performing either a postural stability maintenance training (SMT) or a ballistic ankle strength training (BST) were compared to a non-training group. The hypothesis was that practicing of a self-i...

journal_title：Brain research

authors： Beck S,Taube W,Gruber M,Amtage F,Gollhofer A,Schubert M

更新日期：2007-11-07 00:00:00

abstract：:We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine. The hypothesis was not supported; the pat...

journal_title：Brain research

authors： Bureau YR,Peredery O,Persinger MA

更新日期：1994-06-20 00:00:00

abstract：:The purpose of this study is to reveal whether the application of immunohistochemical examinations to the peripheral nervous system (PNS) can be a reliable method for the quantitative analysis of the blood-nerve barrier (BNB) and the relationship between restoration of BNB and nerve regeneration. Sciatic nerves in rat...

journal_title：Brain research

authors： Omura K,Ohbayashi M,Sano M,Omura T,Hasegawa T,Nagano A

更新日期：2004-03-19 00:00:00

abstract：:Studies have demonstrated defects of DA and 5HT neurotransmission in dietary fat induced obese animals. In the present study, we used a perfusion system to assay the release of DA and 5HT from striatal slices preloaded with [(3)H]-DA or [(3)H]-5HT. The release of both DA and 5HT from striatal slices of rats fed a high...

journal_title：Brain research

authors： York DA,Teng L,Park-York M

更新日期：2010-08-19 00:00:00

abstract：:Intracerebroventricular administration into sedentary mice of the high molecular mass fraction of cerebrospinal fluid (CSF) from exercise-exhausted rats produced a decrease in spontaneous motor activity [K. Inoue, H. Yamazaki, Y. Manabe, C. Fukuda, T. Fushiki, Release of a substance that suppresses spontaneous motor a...

journal_title：Brain research

authors： Inoue K,Yamazaki H,Manabe Y,Fukuda C,Hanai K,Fushiki T

更新日期：1999-11-06 00:00:00

abstract：:The rate of 6-[14C]D-glucose oxidation in cerebral cells of SAMP8, a substrain of senescence accelerated mouse, was investigated in vitro. The production of 14CO2 in dissociated intact brain cells prepared from the cerebrum of 4-8-week-old SAMP8 was higher than that of age-matched SAMR2 as a control mouse, while no di...

journal_title：Brain research

authors： Sato E,Inoue A,Kurokawa T,Ishibashi S

更新日期：1994-02-21 00:00:00

abstract：:Intracisternal injections of hypocretin-1 (hcrt-1) have been shown to elicit sympathoexciatory responses. However, the location of central sites that may mediate these cardiovascular effects have not been clearly elucidated. This study was done in male Wistar rats to investigate the effects of microinjections of hcrt-...

journal_title：Brain research

authors： Ciriello J,Li Z,de Oliveira CV

更新日期：2003-11-21 00:00:00

abstract：:The peptide NK1-receptor antagonists, sendide and [D-Trp7]sendide, have been evaluated for antinociceptive activity in the capsaicin test. Both peptides, injected intrathecally (i.t.) 5 min prior to intraplantar capsaicin, produced a dose-dependent reduction of the capsaicin-induced paw licking response. Naloxone (4.0...

journal_title：Brain research

authors： Sakurada T,Yogo H,Katsumata K,Tan-No K,Sakurada S,Kisara K,Ohba M

更新日期：1994-06-27 00:00:00

abstract：:The possible interference of nitric oxide (NO) in glucose metabolism was studied in activated astrocytes. Lipopolysaccharide (LPS) treatment triggered a NO-mediated increase in glucose consumption and lactate production, suggesting an enhanced rate of glycolysis. Active glycogen synthesis was also observed after LPS t...

journal_title：Brain research

authors： Almeida A,Cidad P,Bolaños JP

更新日期：2002-07-26 00:00:00

abstract：:The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment conti...

journal_title：Brain research

authors： Robinson GB

更新日期：1991-10-18 00:00:00

abstract：:As a means of probing the chemotransducer, impulse sequences from in vitro, superfused sinus nerve-carotid body preparations were analyzed for departures from randomness. Twelve of 17 spike trains showed interval histograms that did not differ significantly from exponential. Thus these sequences resembled a Poisson (r...

journal_title：Brain research

authors： Nolan WF,Donnelly DF,Smith EJ,Dutton RE

更新日期：1984-01-30 00:00:00

abstract：:The function of the phosphoinositide signal transduction system and the levels of heterotrimeric G-protein alpha-subunits were examined in postmortem prefrontal cortex regions (8/9) and region (10) from suicide victims with major depression and matched control subjects without psychiatric illness. The hydrolysis of [3...

journal_title：Brain research

authors： Pacheco MA,Stockmeier C,Meltzer HY,Overholser JC,Dilley GE,Jope RS

更新日期：1996-06-03 00:00:00

abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...

journal_title：Brain research

authors： Crow T,Pengidore T

更新日期：1993-11-19 00:00:00

abstract：:Several lines of evidence indicate that psychostimulant withdrawal can induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dysfunction of the serotonin (5-HT) system, including alterations in 5-HT receptors. For example, changes in 5-HT(2A) receptor function in prefrontal ...

journal_title：Brain research

authors： Horner KA,Gilbert YE,Noble ES

更新日期：2011-05-16 00:00:00

abstract：:Glucagon like peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system and has been implicated in the control of hypothalamic-pituitary function and food intake. GLP-1 immunoreactive (IR) fibers and terminals are widely distributed in the septum, hypotha...

journal_title：Brain research

authors： Sarkar S,Fekete C,Légrádi G,Lechan RM

更新日期：2003-09-26 00:00:00

abstract：:Stroke is one of the leading causes of unnatural death and disability. No effective therapy is available. Recombinant human granulocyte colony-stimulating factor (rhG-CSF), as a mobilizing agent for bone marrow stem cells, can promote stem cell mobilization, homing to brain after cerebral ischemia. In the present stud...

journal_title：Brain research

authors： Yanqing Z,Yu-Min L,Jian Q,Bao-Guo X,Chuan-Zhen L

更新日期：2006-07-07 00:00:00

abstract：:(1) Changes during development in the levels of proteinases and peptidases were measured in brain homogenates. At all ages di- and tripeptidase levels were 7-15-fold higher than proteinase activity. (2) Cathepsin A and D and neutral proteinase activity first decreased (during the 5 days before birth) and then increase...

journal_title：Brain research

authors： Marks N,Stern F,Lajtha A

更新日期：1975-03-21 00:00:00

abstract：:Despite the significant advances that have been made in understanding the pathophysiology of cerebral ischemia on the cellular and molecular level, only one drug, the thrombolytic tissue plasminogen activator (rt-PA), is approved by the FDA for use in patients with acute ischemic stroke. Therefore, there is a critical...

journal_title：Brain research

authors： Maher P,Salgado KF,Zivin JA,Lapchak PA

更新日期：2007-10-10 00:00:00

abstract：:The technique of intracellular recording was used to assess the effect of SR 31742A, a selective sigma receptor ligand, on N-methyl-d-aspartate (NMDA) and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated responses in pyramidal cells of the rat medial prefrontal cortex in vitro br...

journal_title：Brain research

authors： Liang X,Wang RY

更新日期：1998-10-05 00:00:00

abstract：:The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was sensitive to lesions induced by focal cerebral ischemia. Sprague-Dawley rats were pre-screened for startle reflex responses 3-6 days prior to surgery and there were ...

journal_title：Brain research

authors： Maynard KI,Sukoff SJ,Ji Z,Wettstein JG,Black MD

更新日期：2005-01-25 00:00:00

abstract：:1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...

journal_title：Brain research

authors： Puel JL,Bobbin RP,Fallon M

更新日期：1989-05-15 00:00:00

abstract：:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...

journal_title：Brain research

authors： Larsen KD,Sutin J

更新日期：1978-11-17 00:00:00

abstract：:Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...

journal_title：Brain research

authors： Sumners C,Gault TR,Fregly MJ

更新日期：1991-06-28 00:00:00