Abstract:
:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distributed throughout the nucleus. While some cells projected to more than one region, particularly VA and CM, collaterals were not found in most cells. STN stimulation suppressed firing of some EPN cells for 80-120 msec in both barbiturate anesthetized and cerveau isolé cats. Suppression of activity was detected in most EPN cells projecting to LHB (73%); of all cells in which suppression of activity was detected, 84% projected to LHB and 15% to VA.
journal_name
Brain Resjournal_title
Brain researchauthors
Larsen KD,Sutin Jdoi
10.1016/0006-8993(78)90993-9subject
Has Abstractpub_date
1978-11-17 00:00:00pages
21-31issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(78)90993-9journal_volume
157pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The origins of nitric oxide synthase (NOS)-containing nerve fibers in the rat basilar artery were studied by a combination of Fluoro-Gold retrograde tracing and immunohistochemistry. After application of Fluoro-Gold onto the middle part of the basilar artery, the dye accumulated in the sphenopalatine, otic, trigeminal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01212-5
更新日期:1996-01-08 00:00:00
abstract::Antagonism of the alpha receptor sub-type at gamma-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABAA receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90222-4
更新日期:1994-07-04 00:00:00
abstract::α-Synuclein (α-syn) and oxidative stress play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, the mechanisms underlying the interaction between α-syn and oxidative stress remain poorly understood. The present study provides evidence to suggest that the nuclear translocation of α-syn increases d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.01.024
更新日期:2013-03-15 00:00:00
abstract::In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00139-x
更新日期:1997-05-16 00:00:00
abstract::Disturbed synaptic transmission contributes to the pathophysiology of mood disorders. Post mortem studies reported reduced expression of the synaptic vesicle protein (SVP) complexins I and II in depression. Antidepressants were found to induce the expression of these genes. Since animals with congenital susceptibility...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.066
更新日期:2007-05-04 00:00:00
abstract::Mechanisms of neuronal death following neuronal damage due to domoic acid are not completely defined. Bcl-2, a survival protein, protects neurons from ischemia and excitotoxin-induced damage. We previously demonstrated that Bcl-2 shuttles calcineurin to its substrates and may regulate calcium release from internal sto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.076
更新日期:2004-07-16 00:00:00
abstract::The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91147-3
更新日期:1985-09-09 00:00:00
abstract::A study has been made of the effects of a series of excitatory amino acid receptor antagonists on the field potentials evoked on electrical stimulation of the lateral olfactory tracts of olfactory cortex slices perfused in vitro. The antagonists studied included (+/-)-2-amino-5-phosphonovaleric acid, a potent, specifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90090-7
更新日期:1982-07-29 00:00:00
abstract::We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01505-9
更新日期:1998-03-16 00:00:00
abstract::A reduction in adenosine deaminase acting on RNA 2 (ADAR2) activity causes the death of spinal motor neurons specifically via the GluA2 Q/R site-RNA editing failure in sporadic amyotrophic lateral sclerosis (ALS). We studied, over time, the spinal cords of ADAR2-knockout mice, which are the mechanistic model mice for ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.01.006
更新日期:2014-03-06 00:00:00
abstract::The cortical afferents from individual laminae of the dorsal lateral geniculate nucleus (LGN) were studied using both light and electron microscope autoradiography. In area 17, the A geniculate laminae (A and A1) had two main bands of projection, one extending from the bottom of IVc to the deepest cells in layer III, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90002-0
更新日期:1976-08-20 00:00:00
abstract::Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91245-n
更新日期:1993-02-19 00:00:00
abstract::Chicks of 1-8 days after hatching were submitted to unilateral visual deprivation and, in both optic lobes, muscarinic receptors, labeled with L-[3H]quinuclidinyl benzylate [( 3H]L-QNB) and acetylcholinesterase (AChE) were assayed. Between 1 and 6 days the number of [3H]L-QNB binding sites was lower in the contralater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90313-4
更新日期:1984-06-01 00:00:00
abstract::Physical exercise can induce brain plasticity and reduce the cognitive decline observed in type 1 diabetes mellitus (T1DM). We investigated the effects of physical exercise to prevent or reverse spatial memory deficits produced by diabetes and some biochemical and immunohistochemical changes in hippocampal astrocytes ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.024
更新日期:2017-01-15 00:00:00
abstract::Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.06.029
更新日期:2010-08-12 00:00:00
abstract::Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains. We have therefore examined age-related changes in CBP expression in the cerebral cor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03562-x
更新日期:2002-11-29 00:00:00
abstract::We evaluated the effects of glycine exposure upon CA1-evoked response in the rat hippocampal slice. Exposure to 10 mM glycine for 16 min produced rapid neuronal firing and increased orthodromic population spike (PS), followed by loss of CA1 neural transmission. Upon recovery, CA1 orthodromic and antidromic PS regained...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91961-5
更新日期:1994-11-21 00:00:00
abstract::Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91425-g
更新日期:1990-04-30 00:00:00
abstract::A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91218-0
更新日期:1983-03-14 00:00:00
abstract::The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00960-3
更新日期:1998-11-23 00:00:00
abstract::Fast axonal transport and neuronal protein synthesis was studied in the isolated nervous system of Aplysia californica. The abdominal ganglion with attached pleural-abdominal connectives (PAC) was removed and the ganglion pulse-labelled with [35S]methionine for 30 min in vitro. The axon containing connectives were lig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90388-9
更新日期:1985-04-15 00:00:00
abstract::The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrai...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91058-m
更新日期:1992-11-13 00:00:00
abstract::Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90807-9
更新日期:1987-03-17 00:00:00
abstract::The neurophysiological effects of a novel, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester), CGP 39551, on the high pressure neurological syndrome (HPNS) were investigated in the non-human primate Papio anubis. Six animals wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90817-7
更新日期:1993-09-17 00:00:00
abstract::The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.03.001
更新日期:2007-06-02 00:00:00
abstract::Spinally-projecting A5 neurons were studied with anatomical and electrophysiological techniques in the rat. A detailed study of the number and distribution of spinally-projecting catecholaminergic (CA) and non-catecholaminergic neurons present in a defined area of ventrolateral pontine reticular formation was performe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90206-3
更新日期:1984-06-11 00:00:00
abstract::The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90337-9
更新日期:1986-05-14 00:00:00
abstract::Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90941-2
更新日期:1985-12-09 00:00:00
abstract::Paranodal glial loops (lateral belt cytoplasm) of myelinated CNS and PNS fibres contain tubules of agranular reticulum, as well as microtubules, wound spirally around the axon. Similar agranular elements run circumferentially in the expanded rims of sheet-like astrocytic processes encapsulating thalamic synaptic glome...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90414-x
更新日期:1980-09-08 00:00:00
abstract::Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat spinal cord. Where...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(10)80048-4
更新日期:1992-06-26 00:00:00