Effect of early unilateral visual deprivation on cholinergic muscarinic receptors and acetylcholinesterase in chick optic lobe.

Abstract:

:Chicks of 1-8 days after hatching were submitted to unilateral visual deprivation and, in both optic lobes, muscarinic receptors, labeled with L-[3H]quinuclidinyl benzylate [( 3H]L-QNB) and acetylcholinesterase (AChE) were assayed. Between 1 and 6 days the number of [3H]L-QNB binding sites was lower in the contralateral optic lobe; the AChE underwent a drastic reduction (-42% at 2 days); later on the differences became not significant. The pre- and postsynaptic localization of the two cholinergic markers and the possible influence of light on axonal transport are discussed.

journal_name

Brain Res

journal_title

Brain research

authors

Jerusalinsky DA,De Robertis E

doi

10.1016/0165-3806(84)90313-4

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

279-83

issue

2

eissn

0006-8993

issn

1872-6240

journal_volume

316

pub_type

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