Botulinum A toxin and tetanus toxin do not affect presynaptic membrane currents in mammalian motor nerve endings.

Abstract:

:The hypothesis according to which BoTx and TeTx block neuromuscular transmission by impairing Ca2+ influx was tested by recording presynaptic membrane currents at motor endplates of the mouse by means of external electrodes. The use of K-channel blockers allowed us to observe inward Ca current which was unaffected by bath application of BoTx or TeTx at doses which block neuromuscular transmission.

journal_name

Brain Res

journal_title

Brain research

authors

Dreyer F,Mallart A,Brigant JL

doi

10.1016/0006-8993(83)90617-0

subject

Has Abstract

pub_date

1983-07-04 00:00:00

pages

373-5

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90617-0

journal_volume

270

pub_type

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