Abstract：
:The sexually dimorphic nucleus of the preoptic area (SDN-POA) is the most striking structure displaying a morphological sex difference in the rat brain. A potentially homologous nucleus has been identified in the human hypothalamus. The objective of the present study was to pursue the putative homology of the rat and human SDN-POA by determining whether they express the same transmitter phenotype. We employed in situ hybridization histochemistry for GAD mRNA to show whether the neurons of the SDN-POA produce GABA. In both the rat and human, high levels of GAD65 and GAD67 mRNA are present in most, if not all, SDN-POA neurons. No sex difference is evident in the level of expression in either the rat or human. The data indicate that neurons of the SDN-POA in both the rat and human are GABA-producing and argue for the homology of these nuclei in the rat and human hypothalamus.
journal_name
Brain Resjournal_title
Brain researchauthors
Gao B,Moore RYdoi
10.1016/s0006-8993(96)01005-0subject
Has Abstractpub_date
1996-12-02 00:00:00pages
163-71issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)01005-0journal_volume
742pub_type
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